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Replacing 100 % chemical choline chloride - Raw material summary

Published on: 02/22/2022
Author/s : David Revilla, Veterinarian

Liptosa newsletter. Monthly ReportRAW MATERIALS SUMMARYWe have started the year 2022 with the same instability and volatility of raw materials suffered during 2021.In this volume of our newsletter, we would like to tackle/mention interesting alternatives to raw materials, which allow an affordable supply and provide added advantages. Let's talk about choline.The most common source of choline i...

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Mike Stahl Mike Stahl
Poultry manager
February 22, 2022
this product is very interesting

were can i buy this product from in Canada

am very interested in trying it in my 32000 bird organic layer operation

thanks mike
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
February 22, 2022
Dear Mike Stahl,
We are happy to know about your interest in Naturcolin, unfortunatelly it is not available in Canada so far.
Best regards,
Ewa Sujka
Reply
Ahmad Fayez Tayeh Hamdan Ahmad Fayez Tayeh Hamdan
February 23, 2022
Dear Ewa Sujka
What is the choline content in your product?
Reply
Mike Stahl Mike Stahl
Poultry manager
February 23, 2022
Ewa Sujka please let me know when it might be available

have you started the registering process with CFIA
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
June 22, 2022

Dear Ahmad Fayez Tayeh Hamdan,
It is not only about choline content but also about its bioavailibility to the animal. 250-300g of our product may replace 1kg of choline chloride 60%.

Reply
tartarini cesare tartarini cesare
Agricultural science specialization in animal nutrition
February 23, 2022

Hi, it's possible to have this product in Italy? Thank you in advance.

Reply
David Revilla David Revilla
Veterinary Doctor
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
February 24, 2022
Dear Mr. Cesare Tartarini,
I will send you the by private message the contact details for Italy, so you can get the product.
best regards.
Reply
Syed Farjad Zaidi Syed Farjad Zaidi
April 6, 2022
Sure would like to know more for choline substitution,any effective way out will help to reduce cost of production with out compromising efficiency.
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
April 7, 2022
Syed Farjad Zaidi
Dear Syed,
Please be so kind and indicate whre are you based, so we may indicate how to fined the nearest distribution point.
All the best
Reply
Syed Farjad Zaidi Syed Farjad Zaidi
April 8, 2022
Dear Ewa Sujka,Good day
I am based in Multan a city right in the center of Pakistan.
Regards
Farjad
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
April 13, 2022
Dear Syed Farjad Zaidi,

Our distributor from Pakistan will contact you soon.
Best regards,
Reply
Dr. Piotr Stanislawski Dr. Piotr Stanislawski
Nutritionist
DSM DSM
April 13, 2022
What is the equivalent of your product vs 100 g choline ( or choline chlorid) and price indication for 1 kg of your product? Other way we can not compare it
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
April 13, 2022
Dear Dr. Piotr Stanislawski
250-300g of our product may replace 1kg of choline chloride 60%. What concerns the cost of the product - the cost of product per metric ton of feed will not be higher than of cholin chloride.
Reply
Dr. Piotr Stanislawski Dr. Piotr Stanislawski
Nutritionist
DSM DSM
April 14, 2022

Ewa Sujka It means that 600 g CC we can replace with 300 g your product; the concentration is double. How to describe it in LCF program? As choline or choline chlorid? The equivalent content in 1 kg product (1200 g CC in 1 kg product?).

Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
April 20, 2022
Good day Dr. Piotr Stanislawski
1 kg of choline chloride with concetration 60% can be replaced by 200-300 grams of Naturcolin.
Reply
Megan Edwards Megan Edwards
Animal Nutrition
June 16, 2022
Dr. Piotr Stanislawski

This is a good question. I had the same issue as I formulate to a choline value. In the formulation software you must assign a choline or choline equivalent value. CC60% is 52% Choline. If we assume Herbal choline to be 2 x potency it means it is 104% Choline. It does look silly (but so does adding a total calcium value on a phytase matrix). Perhaps in the future we will have digestible choline figures?

There is some evidence to support this bio-equivalency in poultry, but there is still a lack of evidence for pigs. I hope Liptosa will publish more evidence on Bio-equivalency soon.
Reply
Dr. Fiodor S. Marchenkov Dr. Fiodor S. Marchenkov
September 7, 2022
Megan Edwards Dear Mrs.Megan, thanks for your opinion. I'm biochemist by my education, Ph.D. My first question to choline replacers was about choline content in herbal product. It is practically zero. It is not clear for me, what is the name of active substance containing at herbal cholin replacer? Short answer - one word.
Reply
Mr. Pravin Jaiswal Mr. Pravin Jaiswal
AVP - Sales & Technical
ABTL Advanced Bio-Agro Tech Ltd ABTL Advanced Bio-Agro Tech Ltd
Pune, Maharastra, India
April 20, 2022
If I am not wrong you want to say that your product is 3X of CC 60%.
Reply
Viorel Marculescu Viorel Marculescu
Sales & Technical Director Animal Nutrition Russia & CIS
April 20, 2022
This product would be interesting in Russia...if you can export there.
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
April 21, 2022
Hi Viorel Marculescu,
Thank you for the suggestion, well noted :-)
Reply
Nelson Ruiz Nelson Ruiz
Chemist, MS, PhD
April 22, 2022
Dear Ewa Sujka, may I know what is the chemical structure of Naturcolin? Thank you.
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
June 22, 2022
Good day Nelson Ruiz,

Phosphatidylcholines (PC) supported by botanical extracts with sparing effect to PC
Reply
Mete Aydin Mete Aydin
May 2, 2022
Do you have a distributor in Turkey?
Reply
David Revilla David Revilla
Veterinary Doctor
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
May 3, 2022
YEDI VET TARIMSAL FAA. TIC. VE LTD. STI. thank you very much for your interest in our product. Could you please send me your email so I can write you directly?
thank you in advance.
Reply
Mete Aydin Mete Aydin
May 3, 2022
David Revilla,mete.aydin@yedivet.com
Reply
Saad Amjid Saad Amjid
Student
May 12, 2022
David Revilla chsaadamjid7@gmail.com this is my email.
Reply
Muhammad Mubasher Muhammad Mubasher
production manager
July 9, 2022
Dr.m.mubashar@gmail.com
Reply
Arian khorshidi Arian khorshidi
??????? ???? ????????
September 16, 2022
Khorshidi711@gmail.com
Reply
diwakar tiwari diwakar tiwari
Student
June 13, 2022
David Revilla I am interested to know about the product could you please share the details in my email
diwakar.tiwari2020@gmail.com
Reply
Gemunu Widyaratne Gemunu Widyaratne
June 20, 2022
Is this product available in North America?
Reply
David Revilla David Revilla
Veterinary Doctor
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
June 20, 2022
Gemunu Widyaratne, thank you very much for the interest in our product. Unfortunately, the product is not registered yet in North America.
Reply
Muhammad Salman Akram Muhammad Salman Akram
Doctor of Veterinary Medicine
June 21, 2022
Give scientific background for your product. Just saying a herbal mixture is not enough.
Reply
David Revilla David Revilla
Veterinary Doctor
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
June 22, 2022
Muhammad Salman Akram, please be so kind to provide us your email address and our Area Manager will contact you. Thank you!
Reply
Luis Fernando Vergamini Luna Luis Fernando Vergamini Luna
June 23, 2022
Is the NATURCOLIN available in Brazil?

If possible, I would like to have more tecnhical information and trials, to support the usage.
luisluna@allegrolf.com.br

Best regards,
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
June 24, 2022

Good day Luis Fernando Vergamini Luna,
Our technical manager will contact you by private message in order to send you additional info,
Best regards

Reply
Murat BAYAR Murat BAYAR
June 24, 2022
David Revilla I am interested to know about the product could you please share the details in my email : muratbayar1@gmail.com
Reply
Alvaro Dubois Alvaro Dubois
Consultor Técnico en Cargill
June 24, 2022
Dear Dr. Ewa. Is this the same product formerly know as BioCholine? Thank you.
Reply
Javier Gonzalez Foretic Javier Gonzalez Foretic
Médico Veterinario Zootecnista
July 1, 2022
Alvaro Dubois
Dear Alvaro, no it is not. Is a different product.
Reply
Ghulam Habib Ghulam Habib
Professor
June 29, 2022
Yes. It would be interesting knowing how much of the chemical cholin we can replace with natural herbal choline.
Reply
Luc Goethals Luc Goethals
Director
June 30, 2022
It's experimentally not easy to determine which share of the added chemical choline you can replace by natural sources. We have ran several experiments at European Universities and Research Institutes and the outcome was very inconsistent. The problem is that one has to work with choline deficient control diets, if not, few will be seen. In our trials with a normal control group (no added chemical choline, no added natural one) and besides a chemical and natural group, many times we didn't see any difference at all between the three groups. This would mean indeed that in well balanced diets, extra choline is not that essential. Trials were done in broilers and layers. Maybe for other animal species it's different. Of course from such experiments, one might conclude that you can replace ALL synthetic choline by Natural alternatives.
Reply
Ewa Sujka Ewa Sujka
Commercial Manager
LIPTOSA LIPTOSA
Madrid, Madrid, Spain
July 11, 2022

Luc Goethals,
we had similar experience, in experimental farms it is quite common that negative control group doesn´t show a significant difference to trial and positive control, however it doesn´t mean that the choline (doesn´t matter if synthetic or vegetal source) is not needed in farm animal diets. This is the reason why we always perform trials under different conditions and scenarios of experimental and commercial farms.

Reply
Vinay Kulkarni Vinay Kulkarni
Director
July 30, 2022
Luc Goethals
Yes , you are 100 % correct.
If natural choline product can perform both structural and functional role of Choline, it's possible to replace synthetic Choline chloride. And moreover such products should perform in choline deficient diet. It is observed that such natural products perform better than synthetic Choline chloride as we are avoiding TMA related issues.
Reply
Nisar Muhammad Khan Nisar Muhammad Khan
October 6, 2022
Luc Goethals Thanks sir
Your comment is no doubt very important and informative , leading us to an idea of getting rid of synthetic or other choline addition, spending on this nutrient without any benefit.
Reply
Nisar Muhammad Khan Nisar Muhammad Khan
July 5, 2022
A number of Trials will be needed before using Naturcoline as choline chloride replacer, as blindly trusting such products is not looking ethical.
Reply
Pawan Kumar Mudgil Pawan Kumar Mudgil
Director
July 12, 2022
Total fat content of various diet may differ, can that affect the quantity of choline required in that diet, if yes then, may be that could be reason behind inconsistencies in trials. That means requirement can not be ruled out butTotal fat content decide the requirements.
Reply
Ram Singh Ram Singh
Ph.D. (Animal Nutrition)
July 13, 2022
Choline removes fat from the liver. Aflatoxin contamination in poultry feed results in fat accumulation in liver. Under such conditions, choline is required to be added in diet.
Dr Ram Singh Bibyan
Reply
Nabil Tanios Nabil Tanios
prof. Poultry Diseases
July 14, 2022

Excess of choline chloride in ration of commercial laying hens produce a refused taste of eggs, for that we can’t open the amount of choline according to fat content in liver.

Reply
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