Relative Bioavailability of DL and L-Methionine in Broilers

I wonder if you come up with the same differential or conclusions if the data is analyzed on a grams of methionine consumed rather than the %s?

*What is most significant reason we add DL and L- Methionine in broilers? *What products will you recommend for me to use here in Nigeria, Abuja *The above mentioned be use for other birds such as layers etc

Ok thanks

Dr. Enric, I don't think so. I did understand. The point is, if low consumption occurs at high methionine levels, some essential amino acid loss may occur, precisely because levels of other, more specific amino acids or lysine are the levels used in animal use, we get in use, if consumption decreases. I hope I have clarified my opinion on the subject at hand.

Dr Enric, I would like to complement by stating that the amino acid requirement of animals is grams per day. Thus, the amino acid level is established based on the animal's consumption pattern. If consumption variation occurs, in this case due to the high high level of methionine, amino acid deficiency may occur precisely that of lysine, which is provided in the requirement of the animal.

Hello Professor Kim, it is a pleasure to participate in a debate forum that has your participation. Congratulations on your studies, which have contributed significantly to the development of pig nutrition. I want 2020 to be a year of personal and professional achievements. With my admiration, hugs

Many Thanks Dr. Enric Esteve-Garcia

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in addition to the rest of notes were presented by colleagues the antagonism between Meth. and other amino acids should be considered

good activities

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Sir , It is somewhat confusing to me I am not getting the exact meaning of article according to you by using DL -methionine at higher level consumption of feed is reduced but other essential amino acid deficiency may be occur . I found in many formulations liquid as well as powder they are adding more methionine, lysine than that other amino acids . Finally Dl-methionine quantity to be reduce or not to reduce? which will beneficial in formulation ?

This is an extremely interesting study for me. Without going into details, the results are quite expected. However, due to what part of the reduced use of DL-methionine logically, we should expect that due to D-methionine, which is foreign to the body. About 30 years ago, I found that DL-methionine in chickens was induced by cytochrome P-450 in the liver. Cytochrome is induced by a number of foreign compounds, which in our case includes D-methionine. Induction of cytochrome P-450 increases the resistance of chickens to aflatoxicosis. A fact previously described in the literature, but not explained. Medications are also foreign substances to the body and consumption of DL-methionine will activate their elimination from the body. Therefore, during the treatment of animals, synthetic methionine and its analog should be excluded from feed. This is a very interesting and unexplored area of science. I lost my lab during perestroika and went to work for a commercial firm. I am many years old and these dreams are not possible. However, if You are interested in this direction, I am ready to provide advice

I am a little bit surprised by the data. Max supplemented Met level was 0.2% and at this level main performance parameters, WG and FCR reached to same asymptote (even in 0.15%) , I am doubtful about this. Sometimes this is happened when there is another limiting factor. Specially with the presence of other limiting amino acids in supplemented form, the possible supplemented Met source should be in a level much higher than 0.2%. Furthermore, both R square and confidence interval of the regression are missed in the report. As mentioned by others as well, considering met intake rather than Met % in the diets make the results more reliable and comparable.

I need to reconsider in my last two previous comments about R square and confident interval as both are mentioned in the report. It seems that data also plotted based on Intake and not %. ........ My mistake. But Reported RBV and confidence interval in table 6 representing no significant difference between two met sources. Feed Intake – RBV 99% - Confidence interval (71-128) , 99% is within the range 71-128% Body weight – RBV 89% - Confidence interval (78-100 ) , 89% is within the range 78-100% ADG – RBV 89% - Confidence interval (78-100 ) , 89% is within the range 78-100% F/G – RBV 77% - Confidence interval (51-103) , 77% is within the range 51-103%

Dear all, For the feed mill nutritionists, who want to know exactly the practical application of L-Methionine in their formulation and want to discuss the benefits of using L-Methionine in practice please contact me directly. Kind regards,

Dear Enric Esteve-Garcia et al ! Your work is done accurately and professionally. A small remark: the figure 1 shows a graph not of methionine availability, but a graph that reflects the dependence of body weight on the dose of methionine in the diet. Bioavailability in the physiology and biochemistry of nutrition has a different sense. However, this small remark does not affect the value of the study. Returning to my previous comment, I recall that I studied the effect of DL-methionine on the induction of cytochrome P-450 in order to weaken the effect of aflatoxin on chickens. If your study were repeated on a diet containing 3-5 MIC aflatoxin, the results would be in favor of DL-methionine