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Relative Bioavailability of DL and L-Methionine in Broilers

Published on: 01/02/2020
Author/s : Enric Esteve-Garcia 1, Daulat Rehman Khan 2. / 1 IRTA, Mas Bover, Ctra. Reus al Morell, Km 3.8, E-43120 Constantí, Spain; 2 CJ Europe GmbH, Ober der Roeth 4, 65824 Schwalbach, Germany.

1. Introduction Better growth, economy and environment-friendly commercial broiler production is limited to the right amount of available amino acids for efficient utilization in animal body. All of the crystalline amino acids supplemented in commercial poultry production are in their natural (L-isomer) form except methionine (Met), which may be utilized in its synthetic (D- and L-isomers) form i...

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Alireza rostamkhani Alireza rostamkhani
PHD student poultry science
January 2, 2020

Confidence interval do not negative; if that is negative or involved to 100 two product is same.

Reply
Jack Garrett, PhD Jack Garrett, PhD
Technical Manager
January 2, 2020
I wonder if you come up with the same differential or conclusions if the data is analyzed on a grams of methionine consumed rather than the %s?
Reply
Enric Esteve-Garcia Enric Esteve-Garcia
Nutriólogo
January 7, 2020

Jack Garrett, PhD
Looking at feed consumption data, chickens on DL-met tended to consume more at the low levels and slighlty less at the high level. It is not clear whether consumption is a cause or a consequence for differences in feed consumption, but the fact that at low levels there is more consumption could indicate a slight deficiency, which needs to be compensated by more consumption.

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Jack Garrett, PhD Jack Garrett, PhD
Technical Manager
January 7, 2020
Enric Esteve-Garcia Thanks
Reply
OKUN Babatunde OKUN Babatunde
January 8, 2020
*What is most significant reason we add DL and L- Methionine in broilers?
*What products will you recommend for me to use here in Nigeria, Abuja
*The above mentioned be use for other birds such as layers etc
Reply
Enric Esteve-Garcia Enric Esteve-Garcia
Nutriólogo
January 8, 2020

OKUN Babatunde In principle, all methionine sources are good. It depends on the price and the biological equivalence you assign to each source.

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Martin Smith Martin Smith
Animal Nutritionist
Evonik Animal Nutrition Evonik Animal Nutrition
Hessen, Germany
January 25, 2020
Further to this comment. I often do costing and training exercises looking at the impact of NOT using supplemental amino acids in commercial diets. Every time - in every situation - addition of a methionine source results in the highest cost saving and the highest reduction in crude protein content. As methionine is first-limiting amino acid in poultry feeds, this is not altogether surprising.Of course feed cost reduction is to be welcomed; but in many ways crude protein reduction, with its commensurate improvement on environment and gut health, is even more important. Please feel free to contact me to discuss. MPS
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DARE AKINNIYI LAWRENCE DARE AKINNIYI LAWRENCE
Ph.D. Animal science.
February 14, 2020
Enric Esteve-Garcia. Okun Babatunde. Buy from reputable store and probably from a proprietor who is a nutritionist or a veterinarian. Don't buy from just any salesman. I understood your question than anyone else. UP NAIJA.
Reply
Juarez Donzele Juarez Donzele
Professor
January 16, 2020

Dr. Enric, in my opinion, with the results of his study is not evidenced this trend of variation in bird consumption. Even this effect would favor, in relative terms, lower ones than high methionine levels. This is because increasing consumption at low levels would meet the requirements of all amino acids, while at high levels, by reducing consumption, we would possibly have deficiency of some essential amino acids, which could impair the performance of birds. which did not happen.

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Enric Esteve-Garcia Enric Esteve-Garcia
Nutriólogo
January 17, 2020

Juarez Donzele The diets were formulated to fulfill the requirements of all the other amino acids, so that the only limiting amino acid was methionine.

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Srimanta debnath Srimanta debnath
January 17, 2020
Ok thanks
Reply
Juarez Donzele Juarez Donzele
Professor
January 17, 2020
Dr. Enric, I don't think so. I did understand. The point is, if low consumption occurs at high methionine levels, some essential amino acid loss may occur, precisely because levels of other, more specific amino acids or lysine are the levels used in animal use, we get in use, if consumption decreases. I hope I have clarified my opinion on the subject at hand.
Reply
Juarez Donzele Juarez Donzele
Professor
January 17, 2020
Dr Enric, I would like to complement by stating that the amino acid requirement of animals is grams per day. Thus, the amino acid level is established based on the animal's consumption pattern. If consumption variation occurs, in this case due to the high high level of methionine, amino acid deficiency may occur precisely that of lysine, which is provided in the requirement of the animal.
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Sung Woo Kim Sung Woo Kim
January 18, 2020
Hi Prof Jarez, I think the authors can try to refit the graph (equation) by changing the x-axis to "Intake of supplemented Met" (rather than "% of supplemented Met). RBV can be based on actual intake of testing nutrients. I wish you are well! -Best, Sung Woo
Reply
Juarez Donzele Juarez Donzele
Professor
January 18, 2020
Hello Professor Kim, it is a pleasure to participate in a debate forum that has your participation. Congratulations on your studies, which have contributed significantly to the development of pig nutrition. I want 2020 to be a year of personal and professional achievements. With my admiration, hugs
Reply
houshang lotfollahian houshang lotfollahian
January 20, 2020
Many Thanks Dr. Enric Esteve-Garcia
Reply
Popoola Adesola Popoola Adesola
Student
January 23, 2020
Up
Reply
kamaran abduljalil abbas kamaran abduljalil abbas
Animal Nutritionist
January 24, 2020
in addition to the rest of notes were presented by colleagues
the antagonism between Meth. and other amino acids should be considered
Reply
Juarez Donzele Juarez Donzele
Professor
January 24, 2020

Dr. Kamaran, to complement your suggestion it would be opportune to inform, which would be the amino acids that have antagonism with methionine.

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Khaled Fadlallah Khaled Fadlallah
Bsc in veterinary medicine
January 25, 2020
good activities
Reply
OGUNWOLE, OLUGBENGA OGUNWOLE, OLUGBENGA
BSc Hons MSc PhD
February 21, 2020
You cannot separate the salesman from the products. In Nigeria, i will rather ask buyers to patronize only reputable companies and personalities for quality products. The most potent and proven products as well as the enviable brands/companies are faked up or their products adulterated for every reasons known to criminals in the industry.
Every comer concept, particularly in the face of limited regulations and monitoring is undaunting and permit unwholesome practices. Therefore, if you have name, virtue, or you are successful, you need to closely guide what you have. It is far more difficult to build and maintain a good reputation than to lose or spoil it. Very good evening to all
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Tanaji Valmik Lokare Tanaji Valmik Lokare
March 16, 2020
Sir ,
It is somewhat confusing to me I am not getting the exact meaning of article according to you by using DL -methionine at higher level consumption of feed is reduced but other essential amino acid deficiency may be occur .
I found in many formulations liquid as well as powder they are adding more methionine, lysine than that other amino acids .
Finally Dl-methionine quantity to be reduce or not to reduce? which will beneficial in formulation ?
Reply
Daulat Rehman Khan Daulat Rehman Khan
April 23, 2020
Tanaji Valmik Lokare thank you for your interest. By using L-Methionine in practical formulation you can use minimum 5-10% higher available Methionine matrics value than the normal Methionine Sources.
in this case you can save some money on the formulation cost. If you need more details and exact formulations examples please contact me. Kind regards.
Reply
Dr Valeriy Kryukov Dr Valeriy Kryukov
Doctor in Biological Sciences
April 15, 2020
This is an extremely interesting study for me. Without going into details, the results are quite expected. However, due to what part of the reduced use of DL-methionine logically, we should expect that due to D-methionine, which is foreign to the body. About 30 years ago, I found that DL-methionine in chickens was induced by cytochrome P-450 in the liver. Cytochrome is induced by a number of foreign compounds, which in our case includes D-methionine. Induction of cytochrome P-450 increases the resistance of chickens to aflatoxicosis. A fact previously described in the literature, but not explained. Medications are also foreign substances to the body and consumption of DL-methionine will activate their elimination from the body. Therefore, during the treatment of animals, synthetic methionine and its analog should be excluded from feed. This is a very interesting and unexplored area of science. I lost my lab during perestroika and went to work for a commercial firm.
I am many years old and these dreams are not possible. However, if You are interested in this direction, I am ready to provide advice
Reply
Ali Afsar Ali Afsar
Senior Technical Service Manager Nutrition & Care
Evonik Animal Nutrition Evonik Animal Nutrition
Hessen, Germany
April 21, 2020
I am a little bit surprised by the data. Max supplemented Met level was 0.2% and at this level main performance parameters, WG and FCR reached to same asymptote (even in 0.15%) , I am doubtful about this. Sometimes this is happened when there is another limiting factor.

Specially with the presence of other limiting amino acids in supplemented form, the possible supplemented Met source should be in a level much higher than 0.2%.

Furthermore, both R square and confidence interval of the regression are missed in the report.

As mentioned by others as well, considering met intake rather than Met % in the diets make the results more reliable and comparable.
Reply
Ali Afsar Ali Afsar
Senior Technical Service Manager Nutrition & Care
Evonik Animal Nutrition Evonik Animal Nutrition
Hessen, Germany
April 21, 2020
I need to reconsider in my last two previous comments about R square and confident interval as both are mentioned in the report. It seems that data also plotted based on Intake and not %. ........ My mistake.

But Reported RBV and confidence interval in table 6 representing no significant difference between two met sources.

Feed Intake – RBV 99% - Confidence interval (71-128) , 99% is within the range 71-128%
Body weight – RBV 89% - Confidence interval (78-100 ) , 89% is within the range 78-100%
ADG – RBV 89% - Confidence interval (78-100 ) , 89% is within the range 78-100%
F/G – RBV 77% - Confidence interval (51-103) , 77% is within the range 51-103%

Reply
Daulat Rehman Khan Daulat Rehman Khan
April 23, 2020
Dear all,
For the feed mill nutritionists, who want to know exactly the practical application of L-Methionine in their formulation and want to discuss the benefits of using L-Methionine in practice please contact me directly. Kind regards,
Reply
RAMI SEBAI RAMI SEBAI
April 29, 2020
Daulat Rehman Khan I would like to have more information
Reply
Daulat Rehman Khan Daulat Rehman Khan
April 29, 2020
RAMI SEBAI thank you for the interest please write me a short message at: dr.khan@cj.net. We can arrange a meeting.
Reply
Dr Valeriy Kryukov Dr Valeriy Kryukov
Doctor in Biological Sciences
April 23, 2020
Dear Enric Esteve-Garcia et al !
Your work is done accurately and professionally.
A small remark: the figure 1 shows a graph not of methionine availability, but a graph that reflects the dependence of body weight on the dose of methionine in the diet. Bioavailability in the physiology and biochemistry of nutrition has a different sense. However, this small remark does not affect the value of the study.
Returning to my previous comment, I recall that I studied the effect of DL-methionine on the induction of cytochrome P-450 in order to weaken the effect of aflatoxin on chickens. If your study were repeated on a diet containing 3-5 MIC aflatoxin, the results would be in favor of DL-methionine
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