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Antimicrobials in poultry
Antimicrobial agents are essential tools for treating and controlling bacterial infections in poultry production. Veterinarians have a huge responsibility when using antimicrobials in poultry producing meat and eggs for human consumption. The term ‘judicious use’ of antimicrobials implies the optimal selection of drug, dose and duration of antimicrobial treatment, along with a reduction in inappropriate and excessive use as a means of slowing the emergence of antimicrobial resistance. The proper use of antimicrobials depends on the knowledge of interrelationships between bacteria, antimicrobial, host and consumer. The antimicrobial groups most commonly used in poultry are the betalactams, polypeptides, aminoglycosides and aminocyclitols, macrolides and lincosamides, florfenicol, tetracyclines, sulphonamides, quinolones and fluoroquinolones and ionophores.
Introduction Antimicrobials, including antibiotics, antivirals, antifungals, and antiparasitics, are used to prevent and treat infections in humans, animals, and plants. 1 Microbes can become resistant to antimicrobials as a result of ineffective or prolonged antimicrobial treatment. This resistance may be “innate” owing to the slow and long evolutionary process that microorganisms undergo to adapt to changing environmental conditions; this adaptation is...
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The gastro-intestinal tract (GIT) of poultry has a complex and dynamic microbial community consisting primarily of bacteria whose cell wall contains the structural polymer peptidoglycans (PGNs). Bacterial cell wall recycling is a process whereby bacteria degrade their own wall during growth in order to recover released constituents by active transport. These nutrients are then reutilized to either rebuild the wall or to gain energy (Mayer, 2012). However, in both normal and a challenged GI...
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Travis Schaal talks about the importance of biosecurity to prevent avian influenza outbreaks
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1. Introduction Salmonella is one of the most common foodborne pathogens. The intestinal tract of poultry and other food animals is considered the main foodborne Salmonella reservoir [1,2]. An increasing incidence of antimicrobial resistance (AMR) has been reported in poultry Salmonella isolates where antibiotics are extensively used in production systems [3,4]. Although the link between antimicrobial usage in food animals and clinical treatment failures in human salmonellosis...
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INTRODUCTION Antimicrobial resistance is a major threat to human health (1). Host-directed therapy has emerged as a promising antibiotic-free strategy for disease control and prevention (2, 3). Host defense peptides (HDPs), also known as antimicrobial peptides, are small molecules of the innate immune system featuring antimicrobial and immunomodulatory properties (4, 5). Inducing HDP synthesis is a host-directed antimicrobial therapy that is being actively explored for human and...
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Background Growing concerns over resistance to antibiotics in pathogenic bacteria has resulted in increasing public and government pressure to reduce the use of antimicrobial growth promoters (AGPs) in animal feed. A negative result of AGPs removal is potential increase in incidence of certain diseases in poultry, such as necrotic enteritis and avian salmonellosis. Therefore, effective alternative strategies to prevent...
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Introduction The gastrointestinal (GI) tract of humans and animals is populated with a diverse group of microbes known as the microbiota that include bacteria, fungi, archaea, protists, and viruses, with bacteria being the most predominant [1, 2]. The bacterial microbiota is well known to be critically involved in host physiology and immune development [1, 2]; however, the role of the fungal community, known as the mycobiota, that plays in health and diseases is less studied and...
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Campylobacter spp . is one of the most frequent causes of foodborne gastroenteritis having zoonotic importance, and the emergence of antimicrobial-resistant (AMR) Campylobacter spp. is of particular concern to public health. These potential AMR Campylobacter spp . could be transferred to humans through animal food, particularly chickens (Reddy and Zishiri, 2017). The present study was conducted to estimate the prevalence of AMR Campylobacter spp . and their antibiotic...
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Sometimes chicken flocks resulted in less livability and body weight at seven days of age than other ones without knowing the reason. Besides, this reduced performance at an early age has a carryover effect until the market age. What was the cause? Probably, the lower broiler performance is mostly related to the quality of the chicks that arrive at the farms. Indeed, the broiler breeders, incubation process, or in-ovo feeding impact on chick quality. The eggshell temperature, brooding...
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INTRODUCTION Early bacterial colonization of the intestine can alter its morphology, physiology, and susceptibility to infectious diseases (Diaz-Carrasco et al., 2019). The intestinal microbiota plays a critical role in the development and maturation of the gut and its lymphoid structures, and in the function of immune system cells (Hooper et al., 2012; Maki et al., 2019). Initial interactions between commensal bacteria and the host immune system can shape microbiota...
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Chris Morrow (Bioproperties) discusses antimicrobial resistance, as well as prevention of mycoplasma, and the need for continuous change in poultry production....
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I have a doubt upon azithromycin use in poultry, that is as we know the half life of azithromycin is min 3days so should we consider the same half life in case of bird?or do we need to administer it like as it says on product 3-4days through water? anyone with good suggestion will be very helpful. ...
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1. Introduction Antimicrobials are routinely used to treat clinical livestock diseases, as well as to control common disease events, or even as animal growth promoters [1]. Though the latter use is not allowed in many countries worldwide, in some still continue using them for prophylaxis and as growth promoters’ purposes [2,3]. Tetracyclines and sulfonamides are some of the most frequently used antimicrobial classes in animal production throughout the world [4]....
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During COVID19 pandemic period, people all over the globe have understood the importance of protein consumption to boost up their immunity. Chicken meat and eggs provide a rich source of protein and known for the high digestible values which contains vitamins and minerals needed for improving overall health and immunity. It is estimated that 25% of the world's meat supply is derived from poultry, i.e. chicken, turkey, duck, geese, domesticated quail, etc. and increasing trend...
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Introduction Poultry producers attempt to control infectious diseases through a variety of means, including appropriate farm management practices and breeding genetically resistant lines (Sartika et al. 2011; Scott et al. 2018). Unfortunately, existing farming conditions favour increased chicken densities in poultry houses, increasing the risk of spreading entero-pathogens such as Salmonella and Clostridium spp. (FAO 2013). For over half a century, veterinarians and poultry...
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There is increasing pressure for the use of antibiotic growth promoters (AGPs) in poultry diets to be discontinued or reduced. In this context, the search for natural additives such as organic acids (OA) and essential oils (EO) has increased. Previous studies have reported beneficial effects on gut health of supplementing poultry diets with these natural feed additives. As in many countries the use of AGP is still allowed and the adoption of programs combining the effects of AGPs with feed...
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Introduction The immune system of poultry is typically divided into innate responses and adaptive responses, and reviews of the avian immune system can be found elsewhere (Korver, 2012; Kogut, et al., 2020). Briefly, the innate response includes non-specific mechanisms of exclusion such as the skin and mucosal surfaces of the digestive tract, lungs and other organ systems with exposure to the outside world. Thus, one of the primary means of...
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This study was done to investigate the viability of using organic acids as alternative replacement to antibiotics as in feed growth promoters and for use in managing broiler chickens in poultry farms around Nairobi in Kenya. The first part of this study was a survey and second part consisted of two feeding trials. The survey was conducted in the environs of Nairobi to determine the extent of antibiotic usage as a therapeutic agent and as a growth promoter....
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Travis Schaal talks about the importance of biosecurity to prevent avian influenza outbreaks
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Introduction Antimicrobial additives have been used since the 1950s and are an important alternative to allow adequate productivity for animals raised under increasingly intensive conditions. As a consequence of the widespread use and results of AGP in livestock production, there is interest in the study of these additives by meet industry and the academic community. A total of 68.200 publications are presented as results when using the words “broiler” and...
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There are two schools of thoughts for treating a flock affected by viral diseases like IB, AI, ND & IBD. Some say we should immediately use antibiotic to counter any secondary bacterial infection in the process. And some say we should give just supportive & symptomatic therapy to flock in case of viral infection i.e bronchodilator, antipyretic, antioxidants/immunity modulators & liver tonics. I would like an opinion of some senior vets on this issue. ...
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