The Mycotoxin Deoxynivalenol Predisposes for the Development of Clostridium perfringens-Induced Necrotic Enteritis in Broiler Chickens

Published on: 04/08/2017
Author/s : Gunther Antonissen 1,2; Filip Van Immerseel 1; Frank Pasmans 1; Richard Ducatelle 1; Freddy Haesebrouck 1; Leen Timbermont 1; Marc Verlinden 1; Geert Paul Jules Janssens 3; Venessa Eeckhaut 1; Mia Eeckhout 4; Sarah De Saeger 5; Sabine Hessenberger 6; An Martel 1; Siska Croubels 2.

  Introduction Worldwide, necrotic enteritis (NE) leads to important production losses, increased feed consumption and mortality rates, and a reduced welfare of broiler chickens [1–4]. The causative agent of NE is Clostridium perfringens, a Gram-positive spore forming bacterium which occurs ubiquitously in the environment, in feed and in the gastrointestinal tract of animals and human...

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Ralph Stonerock Ralph Stonerock
Animal Nutritionist
April 8, 2017

Consider the mucus barrier continuously secreted through the gut. Clostridia normally consume these proteins in a balance of other competing populations. When any disturbance diminishes the norm, clostridia colonies produce reference metabolites that stimulate mucus secretion. Time becomes a part of the replenishing cellar nutrition maintaining this barrier. Exhausted cellular manufacturing adds to deteriorating maintenance of gut barrier, thus furthering the weaken membrane. DON is a foreign metabolite with potential purpose elsewhere that is captured by ingestion and within the location studied here may disrupt mucus production creating the events reported. Possibility?

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Eileen Han Eileen Han
Animal Nutritionist
April 13, 2017
I found some errors in the paper as it should be indicated 3,000 ~4,000 ug/kg (ppb) NOT mg/kg (ppm) of DON was used in the experiment. And 5,000 ug/kg (ppb) is for EU maximum guideline for DON in poultry NOT 5,000 mg/kg (ppm). Please correct them.
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star Gunther Antonissen Gunther Antonissen
Veterinary Doctor
April 13, 2017
This is indeed correct @Eileen Han.
Could the editors of engormix correct this mistakes. I also notice more mistakes such as "2062.6% to 4763.0%" is 20.6 +/- 2.6% tp 47.6 +/- 3.0%, P,0.001 instead of P<0.001. Probably this are just "copy - paste" errors, however, this are important differences.
The original scientific paper can be found on:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108775
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Carlos Avilan Carlos Avilan
Community Manager
April 17, 2017

Thanks for pointing this out. It has been corrected in the article. Our apologies for the inconvenience.

Best regards.

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star Guillermo Craig Guillermo Craig
Animal Nutritionist
April 29, 2017

DON has always been considered (up to now) a low hazard mycotoxin for poultry. This paper is of high value so as to be aware of the effect on enterocyte integrity and Clostridia infection as NE in broilers.
Its consideration has an extra value when antibiotics are withdrawn from broiler rations; such is the case in many countries at present and will be in the near future in many others.

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