The Mycotoxin Deoxynivalenol Predisposes for the Development of Clostridium perfringens-Induced Necrotic Enteritis in Broiler Chickens
Published:April 6, 2017
Summary
Introduction Worldwide, necrotic enteritis (NE) leads to important production losses, increased feed consumption and mortality rates, and a reduced welfare of broiler chickens [1–4]. The causative agent of NE is Clostridium perfringens, a Gram-positive spore forming bacterium which occurs ubiquitously in the environment, in feed and in the gastrointestinal tract of animals and hu...
Consider the mucus barrier continuously secreted through the gut. Clostridia normally consume these proteins in a balance of other competing populations. When any disturbance diminishes the norm, clostridia colonies produce reference metabolites that stimulate mucus secretion. Time becomes a part of the replenishing cellar nutrition maintaining this barrier. Exhausted cellular manufacturing adds to deteriorating maintenance of gut barrier, thus furthering the weaken membrane. DON is a foreign metabolite with potential purpose elsewhere that is captured by ingestion and within the location studied here may disrupt mucus production creating the events reported. Possibility?
I found some errors in the paper as it should be indicated 3,000 ~4,000 ug/kg (ppb) NOT mg/kg (ppm) of DON was used in the experiment. And 5,000 ug/kg (ppb) is for EU maximum guideline for DON in poultry NOT 5,000 mg/kg (ppm). Please correct them.
This is indeed correct @Eileen Han.
Could the editors of engormix correct this mistakes. I also notice more mistakes such as "2062.6% to 4763.0%" is 20.6 +/- 2.6% tp 47.6 +/- 3.0%, P,0.001 instead of P<0.001. Probably this are just "copy - paste" errors, however, this are important differences.
The original scientific paper can be found on:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108775
DON has always been considered (up to now) a low hazard mycotoxin for poultry. This paper is of high value so as to be aware of the effect on enterocyte integrity and Clostridia infection as NE in broilers. Its consideration has an extra value when antibiotics are withdrawn from broiler rations; such is the case in many countries at present and will be in the near future in many others.
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