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How Mepron® can benefit your farm | Evonik

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Influencers "Likes": Claudia Parys
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April 3, 2020

1. What is the main difference in the digestion of Mepron and DL-methionine in dairy cows?
2. How to ensure that all methionine content from Mepron is utilized in specific ruminant metabolism?
Kind regards!
Reply
Claudia Parys Claudia Parys
Ruminant Nutritionist - Global Technical Support
Evonik Animal Nutrition Evonik Animal Nutrition
Hessen, Germany
April 9, 2020
Branko Stuburic
Mepron is equipped with a unique ethylcellulose coating. Feed grade DL-methionine will be used by the rumen microbes. Methionine needs to be protected from microbial degradation to become available for absorption in the intestine and subsequently available for the metabolism including protein synthesis. Mepron's coating enables the methionine in its core to bypass the rumen microbes to a large extent and release the methionine at its fate of absorption, in the small intestine. This coating technology makes Mepron highly bioavailable so that Mepron is the most efficient methionine for ruminants.
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April 5, 2020
The addition of Amino acid to the dairy cows in the formulations came more attention from a few years ago; today most of the farmers are interested in this technology.
The research start up long time ago, as an example when start to study the free methionine and lysine had a relatively high rumen degradation escape values when they were fed to high producing dairy cows (Velle et al., 1997, 1998; Volden et al., 1998).
But this came more popular now when was found that all the amino acid have a complete linked with the bacteriological activity into the digestion process.
As a Dairy Consultant for hot environment’s (in desert, tropical and sub-tropical conditions) we start to develop some trails in the farms using Methionine from different brands, this was a complete new experience because the formulation of the cows to achieve 35-40 lit is not exactly the same like in temperate countries as USA or Europe, also if the principle are the same the feeds quality and the high temperature and moisture has an important influence in the digest process.
About three years ago, we start up some trails in about 4 farms, with about 1 to 2 corrals of 130 cows in each farm with average production of 35 to 40 lit by corral. With the comparative corrals we found that in some cases was not difference in the production with the same formulation, management and environment and only one show a difference of one liter by cow average but it was not economically feasible.
On the following years we continuous testing with different test, and today with about 6,700 milking cows under evaluation we learn the following for hot environment’s:
1) The brand we select is from Kemin as MetiPEARL and LysiPEARL for the best results we had in comparison with other brands (price/quality). 2) When we combine Methionine with Lysine we found better results than using Methionine alone. 3) We found a high reduction in the use of Soybean meal, from 4.5 kg in the original formula to 2.6 kg (according the type of formulation in the farm) keeping the same production. 4) The best improvement was noted in reproduction or conception rate, Fat stability and Protein increase. 5) The best results were noted in the general performance of the cows, more healthy, better BCS (as feed assimilation) and reduction of the minor affections as laminitis, mastitis, etc. 6) The amino acid addition used is a rate of 3/1 (Lys-Met) in base to NRC, and the formulation variation, with about 10 gm. of Met and 20 gm. of Lys (according the formula).
The economic result we do not calculate yet, we consider that some of the results are difficult to evaluate, maybe the most notorious is relate to the reduction of the Soybean Meal used as a directly reduction in the feeding cost.

Gustavo Pourraid Dairy Management Consultancy Services Director of AgriConsultAS LLC
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April 7, 2020
I am of the opinion that if we are feeding rumen protected protein meals like rapeseed, groundnut, soya etc., in the ration then feeding rumen protected lysine may not be essential. However, if the ration is supplemented with rumen protected methionine @ 10-15 g per day, along with rumen protected protein meals, it is highly economical in terms of improvement in quality and quantity of milk.
Reply
Brian Sloan Brian Sloan
Global Ruminant Business Director
Adisseo Adisseo
Oost-Vlaanderen, Belgium
April 20, 2020
Yes AA formulation can be challenging to achieve cost effective rations and maximize performance, minimize metabolic disorders and optimize reproduction, but is certainly very achievable. Protected methionine and lysine should be treated like any other ingredients in the ration. First they should only be selected based on their validated metabolizable methionine and lysine contribution. Afterwards depending on price and availability of other ingredients, protected methionine and lysine sources will be pulled into the ration to meet the requirements. It is now being recognized that success also depends on optimizing the grams of these essential amino acid (nutrients) relative to the metabolizable energy being provided.
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Joe Magadi Joe Magadi
Manager
April 9, 2020
Manget,

A brilliant idea.
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April 9, 2020
Thank you very much for the answers, Dr. Claudia Parys!
Here are two more questions on this topic if you have any advice.
Is the situation similar for lysine and protected lysine?
Is it possible, with a combination of methionine and lysine, in one matrix (fixed ratio) that is also protected from decomposition in the rumen, to have the most accurate feeding possible in order to achieve the best precision nutrition, optimal costs and health of dairy cows and the environment protection?
(eg if there is variability in plant feeds (silage, cereals, soybean meal....), ie differences in CP and AA contents)
KR, BS
Reply
Claudia Parys Claudia Parys
Ruminant Nutritionist - Global Technical Support
Evonik Animal Nutrition Evonik Animal Nutrition
Hessen, Germany
April 14, 2020
Dear Branko Stuburic , the same aspects apply to protected lysine as well. It needs to be well protected from microbial degradation but release the lysine in the small intestine for absorption. A combination of methionine and lysine and one product is convenient from a handling aspect (just one product, not two). It it not the most economical solution because you can't adjust methionine and lysine supply to its respective optimum. If your unsupplemented ration needs more rumen protected methionine than lysine (or vice versa), you have to oversupply one of them to meet the need for other one. This takes away flexibility for ration adjustment according raw material availability, variation in feed quality (nutrient supply) and different needs in the different groups of cows.
Reply
April 9, 2020
Dear Mr. Branco Stuburi, sorry you request the valuable opinion to Dr. Claudia Parys, but for me all which is relate to cows physiology is my passion and of course specifically amino acid which is one of the most important fields, where the science do not advance to much yet. So please allow me to provide some personal opinion to your question about combination of RP Methionine and RP Lysine.
The most required amino acid is the Methionine in the cow’s functions but still important the Lysine and now also start to be included in the research and test the Histidine.
I am a field researcher professional, and following the combination of the first experiences I tested in a large number of dairy cows. I am using a ratio of 3:1 Lys/Met but now some new experiences say that the best combination can be the ratio 3.9:1. Because this was tested in a small number of dairy cows, I decide to start up in the next month a large test with not less that 100 cows.
Is important to clarify that the combination of the use of amino acid in the formulation as an important issue to consider for the best physiology of the cows, and this is depending the environment conditions and type forages, feeds and quality as well formulation and cows requirements.
Actually I am using a ratio of 3 to 1 Lys/Met into the formula result, which mean 10 gm. of Met and 20 gm. of Lys, but this can fluctuate, for this reason I will advice to made your own test according the formulas and adjust according the results in this way you can adjust in reference to your own experience.
Regards
Gustavo Pourraid


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DR.MUHAMMAD SHAFIQUE DR.MUHAMMAD SHAFIQUE
DVM,M.Sc(Hons) vety,pathology
April 20, 2020
It is really good formulation of lysine and methionine for better production of dairy cows and histadine also good for better production of dairy cow
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April 29, 2020

I am interested in the subject, but in relation to the growth performance of weaned market lambs.

That is, to optimize growth performance between 2-6 months of age. Do we have any one with experience in this regard?

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May 18, 2020
Dear Claudia,

what's your take on using a methionine analogue, any down side to it? How do you compare it with pure methionine when the analogue is a precursor of L-Methionine and has a bypass value as well.

Also Mepron is a source of Protected DL-Methionine or is it just L-Methionine? Because D has to be converted to L-Methionine for absorption in the small intestine. Correct me if i am wrong please. Also absorption for pure methionine is a saturable process and takes place through active transport but for an analogue i think its by diffusion so less or no energy dissipated during absorption and less stress in summers.
Reply
Claudia Parys Claudia Parys
Ruminant Nutritionist - Global Technical Support
Evonik Animal Nutrition Evonik Animal Nutrition
Hessen, Germany
May 19, 2020
Shahzaib Shakeel
One half of DL-methionine is already L-methionine. D-methionine is transformed to L but at a slow rate so that the D-form acts as a potential reservoir for L-Met.
The downside of using an analogue is that it is not methionine. It needs to be converted to methionine which consumes energy which is a downside on particular under heat stress conditions. The analogue is a 50:50 mixture of D and L analogue so that the L-form is a direct precursor and the D-form needs to be transformed to L first.

Mepron is a rumen protected DL-methionine. The D-form is aborbed as well and does not need to be tranformed into the L-form to be absorbed. The absorption process is not limiting the methionine uptake. As the absorption of the analogue is a passive process, the uptake is slower and it might not be completely absorbed before intestinal microbes might use it.
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May 19, 2020
Thank you Claudia. Appreciated
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