Issues of the Poultry Recombinant Viral Vector Vaccines which May Cause an Effect on the Economic Benefits of those Vaccines
Published:September 16, 2011
Summary
Summary
Over the last decennia different recombinant viral vector vaccines for poultry have been introduced in several countries.
The first vaccines were all based on the Fowl pox(FP) virus used as the vector (e.g. the avian influenza (AI) recombinant (r) FP/H5, NewcastleDisease (ND) rFP/ND, infectiouslaryngotrachetis (ILT) rFP/ILT vaccines. The most recent ("second generation") vir...
It is really informative article about Recombinant Viral Vector Vaccines . Author has given details about failure of immunity development. It should be helpfullfor better protection through taking care of factors affecting development of immunity. As vector vaccines develop humoral immunity response (antibodies), so by give conventional live vaccine for same particular vector vaccine will give local immunity through cellular immunity process. It shall be helpfull for inhibting the replication of challange virus. As these vaccines are new, all valuable informations/ inputs will be helpful for all the concrned of poultry health.
Regards,
Maqsood Jaffery
Aoa, an informative article about poultry health but why is it suggested to inject at day one bcs at day one it is very difficult to inject the bird
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Dr.Munawar Hasan
14 de octubre de 2011
I found this article about poultry health is very informative specially the possible causes of failure and precautions for avoiding the failure of the vaccine.
Sir in India, live bivalent vaccine ( hvt1 + Sb1) is administered at hatchery level engaged in providing layer chicks. Then at layer poultry farm, this vaccine is repeated as booster for control of Marek disease at day 1/2. Now if we give avian influenza vector vaccine Rhvth5 at day 3, then won't rhvt5 for avian influenza interfere with bivalent live vaccine for Marek? Please advise.
Puneet Jindal,
Rispense is used world over. We are at SB!+HVT. We do get outbreaks of Mareks even with SB1+HVT. Hence we cannot forgo SB1. Mareks can cause more damage beyond the issue of Immuno suppression.
Various recombinant vaccines are being Invented. The manufacturers are claiming life long immunity with Recombinant vaccines. Theoretically it may be true.
I used Mareks +nd recombinant at hatchery for my breeders. I did not have guts to keep away not doing Lasota and R2B for the birds. I wont leave ND protection job in India for the recombinant strand mounted on HVT. The manufacturers should try few batches in endemic areas and prove for 72 weeks the vaccine done at hatchery will protect.
It is the HVT in the first HVT+SB1 vaccine that will interfere on the avian influenza H5 protection induced by the rHVT-H5 in the boost. The Marek's disease protection should be similar as if birds had received two times HVT+SB1 since rHVT-H5 is an HVT. So, Marek's protection should be the same but H5 protection will not be at the expected level.
Hi, Michel Bublot. Thanks for the reply. If we buy chicks from Hatchery without any vaccination and then vaccinate it first with Rhvth5 (avian influenza) on day 1 followed by Marek vaccination ( hvt + Sb1) and avoid booster for Marek Then by doing that, can we expect better and prolonged titres for avian influenza without compromise on Marek disease antibodies Pls note that rispens is not allowed in India and all studies are based on rispens only. So can it be said that rispens is better than Sb1 in ensuring that hvt vectors in both ( hvt+ rispens) and rhvt5 don't interfere with each other
I agree with comments made by Michel
Bublot
Mixing any recombinantHVT vector vaccine with a conventional HVT vaccine will interfere with the protection of the insert like in your case with the AI/H5 protection
As mentioned will not effect the MD protection
To improve protection of the recombinant for MD you can if manufacture recommend to combine the recombinant HVT vector vaccine with SB1 or Rispens
Rudolf Hein
Thks. This answers our concerns.
Can we administer two different killed vaccines or should we go for booster dose of what already been given
For example can we give killed re6 + re 8 ( chineese ) catering to clades 2.3.2.1 and 2.3.2.4after gap of 40- 50 after we have given AI Multi ( h5+h9) of vaksindo ( Indonesia) or we should give booster dose of what been applied earlier
Puneet Jindal
You have to be carefully in combining different type of activated vaccines are not the antigens but the emulsion(Adjuvant) be may not compatible,
What do you mean with:" after gap of 40-50" ?
