George Entz Hello George! We have no specific trial with Coccivac B-52, but we have many other trials with Lumance in poultry. Feeding strategy is crucial in case of antibiotic free production and also for live anticoccidial vaccine efficacy. Anti-nutritional factors in wheat and soy are related with changes in viscosity and chronical intestinal inflammation leading to intestinal microbiota disbalance. This needs to be avoided for ensuring proper live vaccine efficacy which requires exposure to multiple life cycles of Eimerias in the vaccine.
That is why it is important proper usage of enzymes and special intestinal support (anti-inflammatory, balancing the microbiota: Clostridia, etc.). This means that product like Lumance need to be used and vaccine alone cannot give the desired effect if it is used alone in non-antibiotic wheat/soy-based diet.
This is confirmed by MSD in their own recommendations for feed strategy related with their vaccine.