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Showing extremely fragile liver

Published: June 10, 2015
By: Dr. Manoj Kumar Mahato

Dear colleagues,

This is a case of a 6000 layers flock, 36 weeks of age. 1.5 months ago the flock was suspected and tested for salmonellosis which came out to be positive. The flock was treated with gentamicin and bcomplex injection for 3 consecutive days. The mortality was reduced for a few days but then it increased again. The post mortem lesions show extremely fragile liver and blackish necrotic mucosa at the duodenal part. Copper sulphate and vinegar was given in drinking water but mortality was not controlled, 15-20 per day.

Please suggest me the best measure for controlling mortality.

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Authors:
Manoj Kr Mahato
Asian Feeds
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Marwan Nasution
MSD Perú
12 de junio de 2015
thats look like Hepatitis E, please conform with Hystopalogy if so, no treatment work.
Ali Sahmaran
12 de junio de 2015
Be sure that it is not fatty liver syndrom.
Dr Wisal M.Khan
12 de junio de 2015
Hi Please consider BLD / big liver disease it has seen in so many countries and also it may be a cause for it , Virus like Hepatitis is main cause for it , strict biosecuirty measure and good source of feed can prevent it Try to use the Crumbs to avaoid feed factor . Once the infection is there it will continue . find more for it http://www.thepoultrysite.com/diseaseinfo/12/big-liver-and-spleen-disease/ Thanks
Juvy Lago
12 de junio de 2015
looks like bacterial infection. Try to use other antibiotics and supplement with liver tonic and Vitamin ADE.
Samir Mousa
12 de junio de 2015
please revis t the starter feed may be fat content too high , the liver of 1day baby chicik not compleatly developed and its not redy to digest hig level of fat ,so its my be the initial cause
Dr.Anjum  Munir
13 de junio de 2015
Treat it with Flunmiquene. ADEK . use mycofix 150grm per bag of feed it will give good result to you. and kindly clear pic and other organ pic upload
Hany Ellakany
Damanhour University, Egypt
14 de junio de 2015
Dear Colleague: Liver may be affected by something like mycotoxicosis. If there are dudenal inclusion, the possibility of fowl cholera is also present.
Dr. Rama Prasad Chakraborty
14 de junio de 2015
It seems to be a viral disease where liver gets affected.Treatment with antibiotic would aggravate the status.Rather start with immuno modulating therapy with livamisol solution supported by Vit-E with selinium,Vitamin C ALONG WITH HERBAL LIVER TONIC and simply withdraw the current feed regimen by offering fresh crumbled maize in appropriate size for a few days till mortality gets arrested. DR.R.P.CHAKRABORTY,PATNA ,BIHAR
Manoj Kr Mahato
Asian Feeds
14 de junio de 2015
Thanks to all of you for all these valuable suggestions. I am following up the case and will provide you the results very soon.
Angel Alvites Peve
Bionova
14 de junio de 2015

Hi if the lot tested positive for salmonella, the birds become portadoas, that means you must be doing a systemic tartamiento every 5 weeks to prevent mortality.
consider working with an organic acid in the diet and for future work in the lift if allowed two vaccines against salmonella in the Levant and a progrm competitive exclusion.

Andrew Sivaram
14 de junio de 2015
The primary problem appears to be massive liver necrosis and failure. The soft and friable liver is usually seen at the terminal stage when the damaged liver becomes infiltrated with fats. I have seen this in commercial layers affected by either Fatty Liver Hemorrhagic Syndrome (FLHS) or Adenovirus infection. For FLHS, we need to correctly formulate the pullet rations to make sure that their internal organs develop optimally during the starter-grower phase and that they do not get too fat during the developer phase. Adenovirus infection can be controlled by bio-security and by reducing stress factors as there are no known cures at present. I believe that the blackish necrotic duodenal mucosa is caused by the corrosive action of the stomach acid on the mucosa. Since the liver is already so badly damaged, bile production and secretion would have ceased and without bile, the stomach acid is not neutralized upon entry into the duodenum.
cherukuri choudary
14 de junio de 2015
Fragile liver is commoly see in layers with mycotoxicosis .By changing the feed and giving liver tonics for 5 days would control the mortality.
Narayan Banik
15 de junio de 2015
You have got many suggestions I don't know what is the present condition of the birds so far I guess it needs more investigation if u treat ur birds florfenicle20%in drinking water in 5cosecutive day it may control and change feeding materials go for new ration enriched with bit Ade, liver tonic,lincomycine best of luck Dr N C Banik senior poultry consultant Bangladesh
Md. Zahid Hossain
15 de junio de 2015
We need more information like you give culture only for salmonell or other like fowl cholera, toxin test in feed done or not. if culture positive for salmonella and other parameter negative like fowl cholera and toxin level is ok. Give Ciprofloxacin and Amoxycillin 3 to 5 days and colistin sulphate in feed for 10 days and water acidifier ,electrolyte and liver tonic.
Dr.Suryakant Eknath Mohite
16 de junio de 2015
use feed acidifier,liver tonics in water
Atef Abou Zead
16 de junio de 2015
Exclude mycotoxin, we can help this condition with any liver tonic and protective must be containing choline chloride, methionine, cynara and L carnitine
Sudarno
Sudarno
24 de junio de 2015
In this case you need something that can bring fat out of the liver or it's call lipotropic factor. You can use Alimet or Liquid methionine via dringking water. I will reduce mortality.
Ahmed Din Anjum
24 de junio de 2015
After carefully looking at the given photo, please note: 1. The liver appearance and fragility more relate to autolysis rather than any disease. 2. The black colour of the intestines further supports putrefactive change rather than indicative of any disease. Please study more cases in the same flock to declare it "EXTREMELY FRAGILE LIVER".
Manoj Kr Mahato
Asian Feeds
24 de junio de 2015
Dear Ahmed Din Anjum, thanks for your suggestion. This picture was taken in a post mortem of a live sick bird. So is it fair to say its an autolytic or putrefactive change????
Narayan Banik
25 de junio de 2015
Dear Dr Mahato I think u r very kin on ur duties. Could u let me know how did u solve the problem?
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