25 days broiler with nephritis and urate deposition, pale liver, litter material and stones/cement inside gizzard, mild enteritis, stunted growth, depressed with 5-20 birds/day
In case of infection with nephrotropic IB strain , the kidneys of affected birds are pale, mottled, and can be 2 to 3 times their normal size. Urates are common and can be identified easily in the kidneys and ureters at necropsy
I will certainly consider infection with nephrotropic strain of infections bronchitis virus. Histopathology will be helpful. PCR on kidneys for definitive diagnosis.
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The are several publications related to nepheritis with QX IBV strain wre published .
e.g.
Sigrist B., K. Tobler, M. Schybli, L. Konrad, R. Stöckli, G. Cattoli, D. Lüschow, H. M. Hafez, P. Britton, R.K. Hoop and A. Vögtlin (2012). Detection of Avian coronavirus infectious bronchitis virus type QX infection in Switzerland. Journal of Veterinary Diagnostic Investigation 24(6) 1180–1183.
Managemental and disease can be significant factor.
1 water deprivation
2;feed toxicity
3,nephrophthogenic strain of Ib.
Treatment should be accorsing to diagnosis.
Pale , inflammed and hemorrhagic liver and kidneys are mostly seen in case of IBH and/or Mycotoxicosis.
But Finally PCR is helpful, As you can see such lesions in case of Avian Astrovirus infection, Nephropathogenic IB, Chicken Infectious Anemia, Sulphonamide toxicity, Dehydration and Pullorum Disease.
Nephrogenic form of IB,mycotoxin,water deprivation,vitamin A deficiency, streptomycin toxicity etc could precipitate such lession that is being described.
Nephrogenic form of IB, mycotoxin(ochratoxin) visceral gout due to water deprivation, Vitamin A deficiency, streptomycin toxicity(high doses of it) could all precipitate kidney lesion
As Dr. Tahir sb said, we should correlate liver and kidney lesions for field diagnostic approach. In my opinion, we may consider it for Mycotoxins or IBH.