Consider the mucus barrier continuously secreted through the gut. Clostridia normally consume these proteins in a balance of other competing populations. When any disturbance diminishes the norm, clostridia colonies produce reference metabolites that stimulate mucus secretion. Time becomes a part of the replenishing cellar nutrition maintaining this barrier. Exhausted cellular manufacturing adds to deteriorating maintenance of gut barrier, thus furthering the weaken membrane. DON is a foreign metabolite with potential purpose elsewhere that is captured by ingestion and within the location studied here may disrupt mucus production creating the events reported. Possibility?
Thanks for pointing this out. It has been corrected in the article. Our apologies for the inconvenience.
Best regards.
DON has always been considered (up to now) a low hazard mycotoxin for poultry. This paper is of high value so as to be aware of the effect on enterocyte integrity and Clostridia infection as NE in broilers.
Its consideration has an extra value when antibiotics are withdrawn from broiler rations; such is the case in many countries at present and will be in the near future in many others.