Discussion created on 07/13/2020

Mycotoxins and vitamin D in poultry

Mycotoxins interfere in the vitamin D metabolism leading to poor calcium absorption, causing Lameness. Does anyone agree to this point?

Dr. Meesam Raza
Poultry Consultant, PhD- Poultry Science
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Dr M G Nair Dr M G Nair
Doctor of Veterinary Medicine
August 8, 2020

Yes, I agree with the statement. It is already proven that mycotoxins such as aflatoxin, ochratoxin, etc., can interfere with vitamin D/calcium/phosphorus metabolism.

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Ram Singh Ram Singh
Ph.D (Animal Nutrition)
August 11, 2020
Yes, mycotoxins interfere with normal matabolism of Vitamin D. However, mycotoxins interaction with vitamin D is important. It is the level of mycotoxin in feed which is important that interacts with the vitamin D. What level of mycotoxin in feed disrupts the vitamin D metabolism, which has not been researched extensively so far. Therefore, the mycotoxin- vitamin D interaction is inconclusive.
Dr. Ram Singh Bibyan
Principal Scientist
CIRB, Hisar
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Dr. Meesam Raza Dr. Meesam Raza
Poultry Consultant, PhD- Poultry Science
August 11, 2020

Ram Singh Thank you for your valuable insight, sir.

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Emmanuel Nwaotule Emmanuel Nwaotule
Higher Diploma In Animal Health and Husbandry
August 18, 2020

This is very interesting. But , we understand and know that one important quality of mycotoxin binders is that they do not bind or hamper the availability of vitamins including vitamin D, otherwise, egg shell formation and skeletal formation would be impaired. In this situation, therefore, the nutritionist should watch the type of ingredients and the level of mycotoxin contamination in them, in order not to inform or warrant using higher levels of mycotoxin binders in the feed. This would not only reduce feed cost but enhance feed quality and efficiency.

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Joshua Jendza Joshua Jendza
Animal Nutritionist
September 1, 2020

Emmanuel Nwaotule
Such "undesired adsorption" is something few people seem to think much about. And yet, it is why we do not use activated carbon, for example, which is great at adsorbing mycotoxins of all kinds but also binds nutrients of all kinds.

It is this selectivity that differentiates the different sources of bentonite around the world, with Ca-bentonites being more selective than Na-bentonites.

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August 20, 2020

Interesting. Would anybody know what the maximum level of Aflatoxin should be (say roughly over a week) to avoid the interference? I would prefer to have data from experiments without binders.

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Hany Ellakany Hany Ellakany
Professor and vice dean
August 21, 2020
Yes, mycotoxins hinder the mechanism of action of vit D regulation in the body including the absorption, of Ca from intestine, distribution of both bit D and Ca in the body including precipitation in the bone or immobilisation to the egg shell under the control of Calcitionin and parathyroid hormones. On autopsy of broiler chickens feed intoxicated, the long bones are fragile and green stick fractured.
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