I think DFM can play an important role as dietary alternatives to antibiotics and our work also supports this finding that certain strains of bacillus modulate host inflammatory responses and intestinal barrier gene expression of commercial broilers subjected to LPS challenge. Intestinal transcriptomic analysis indicated that B. subtilis-based probiotics differentially regulate intestinal immune and tight junction protein mRNA expression during states of LPS-mediated immunological challenge. (Res Vet Sci. 114:236-243. 2017.)