Feed enzymes and gut health - Anna-Maria Kluenter

When a clostridial infection is underway then enzymes are likely not going to help. In this case veterinarian advice may be needed. However, if clostridial infection is a concern or has been in the past then enzymes can play a role in mitigation of the risks i.e. they are not a cure but may be a preventative measure if deployed prophylactically. Several mechanisms may be of importance here: (1) Many enzymes improve integrity of the mucin layer in the gut by reducing antinutritional factors of e.g. phytic acid or higher molecular weight pentosans. This is important for improving resilience. (2) many enzymes reduce endogenous and indigested dietary protein flow in the hindgut and this reduces opportunity fro putrefactive organisms. Specifically, glycine is of importance because it is one of the key amino acids for clostridial metabolism and it is high in many endogenous secretions - notably mucin and bile. Reducing the flow of such amino acids in the lower part of the gut is beneficial. (3) Viscosity and high concentrations of soluble polysaccharides are associated with clostridial infection and bloom in the ileum. Reducing the viscosity of digesta by arabinoxylanases and beta-glucanases and generating oligosaccharides which are fermented in the caecum, reduce pH, create VFA's for enterocyte metabolism and generally help to keep pathogen numbers under control. (4) Combinations of protease and Vitamin C can improve tight junction via collagen synthesis. Leaky tight junctions are a problem and often Associated with poor gut health and bacterial infection.

Thanks .Anna-Maria Kluenter

Dear Lawal Sesan, that is very good to know. No problem with that.