Carnitine Enigma: From Antioxidant Action to Vitagene Regulation. Part 1. Absorption, Metabolism, and Antioxidant Activities

Published on: 03/22/2017
Author/s : Peter F. Surai 1-5. / 1 Department of Microbiology and Biochemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria; 2 Department of Animal Nutrition, Faculty of Agricultural and Environmental Sciences, Szent Istvan University, Gödöllo, Hungary; 3 Department of Veterinary Expertise and Microbiology, Faculty of Veterinary Medicine, Sumy National Agrarian University, Sumy, Ukraine; 4 Odessa National Academy of Food Technology, Odessa, Ukraine; 5 Russian Academy of Science, Moscow,

Introduction L-carnitine (LC), a naturally occurring and widely distributed in nature compound was discovered in 1905 by Gulewitsch and Krimberg [1]. For the last 50 years this nutrient has received a substantial attention from medical sciences and poultry and pig nutritionists. Main dietary sources of carnitine in poultry/animal nutrition are animal-derived feed ingredients while grains and thei...

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Marco Baroni Marco Baroni
Agro Technician
March 22, 2017
Having in selection sows hyperprolific, has increased the heterogeneity of the birth weight and immature piglets, it is useful to use antioxidants during the weaning-estrus interval?
When the embryo from the first days is subjected to oxidative stress?
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September 17, 2019
Yes, by using carnitine as a part of antioxidant strategy it is possible to improve antioxidant defences piglets in early postnatal development
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Marco Baroni Marco Baroni
Agro Technician
March 22, 2017

It is useful to the use of carnitine in diets for boars, to evaluate the lipid peroxidase membranes of the sperm in the semen boar diluted with BTS and stored for 3 days? Thanks
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September 17, 2019
Yes, carnitine can have some protective effects in vitro
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March 23, 2017

Yes, indeed, carnitine could be a part of the antioxidant mixture to deal with various stresses.

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May 22, 2019

Dr. Peter, I congratulate you on the article. Very interesting reports on the actions of carnitine. I would like to question the effective antioxidant action of carnitine in the metabolism of broilers submitted to heat stress. As I am aware, high temperatures increase the oxidative stress of chickens by decreasing the activity of the UCP decoupling protein. In this case, due to the increase in proton concentration, the mitochondrial membrane potential increases, thus increasing oxidative stress. My question is whether in this case, the carnitine would have some action increasing the activity of the UCP decreasing the oxidative stress.

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September 17, 2019
Dear Juarez, carnitine can improve mitochondria integrity in stress conditions, including heat stress. Since mitochondria are the main source of free radicals in the cell, carnitine can decrease oxidative stress. Furthermore, carnitine can also affect Nrf2 activity and by doing so further increase antioxidant defences
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September 18, 2019
Dr Peter, thank you for your clarification. However, the question remains whether carnitine decreases oxidative stress, while also acting to increase CPU activity in heat.
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September 24, 2019

Hello, gentlemen,
Carnitine products need to be supported by the osmotic regulation of the cell membrane by betaine. That could be the base of antistress factor.

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