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Silvafeed® Nutri P: the right solution to prevent and treat diarrheal diseases

Published: May 17, 2017
By: Silvateam
Gastrointestinal disorders remain a challenge to control and can severely affect the health and welfare of different animal species. Yet, plants produce an impressive array of compounds which can potentially be used as natural solutions to improve gut health.
Tannins are widely spread in the plant kingdom and they are certainly an element of interest in this sense. Thanks to their antibacterial, antiviral or antispasmodic properties (Lupini et al., 2009), they have been traditionally used within ethnoveterinary medicine to treat various illnesses affecting monogastrics, such as diarrhea and other intestinal disorders (Palombo, 2006; Suroowan et al., 2017).
Silvateam is recognised as a world leading player in tannins and,in the last decades, it has been strongly investigating tannin health benefits within animal nutrition.

Silvafeed® Nutri P is a feed additive composed of natural polyphenols (mainly hydrolysable tannins), which have been extracted and purified from various botanical sources. Its antispasmodic effect has been deeply analysed by an ex vivo assessment carried out by Budriesi et al., in 2010. The aim of the study was to provide an evidence of Silvafeed® Nutri P antispasmodic activity, which triggers a reduction in intestinal motility and, therefore, delays gastrointestinal transit, making this extract a helpful tool to prevent or treat diarrheal diseases.
Different gut segments (ileum and proximal colon) were isolated from guinea pigs and incubated with Silvafeed® Nutri P, in order to assess its effect on the contraction (or spasm) of the smooth muscle from the intestinal wall. This mechanism was tested in a series of experiments where muscle contraction was induced by various agonists such as carbachol (CCh), BaCl2, KCl, histamine or serotonin.
As highlighted in the above chart, Silvafeed® proved its strong efficacy in reducing CCh induced muscle contraction of both gut segments. Thus, the tannins antispasmodic activity presented an impact on the different assessed parameters, which may vary in strength depending on the gut locations, either ileum or proximal colon (Figure 1).
Various beneficial effects were obtained with the other tested antagonists.
Silvafeed® Nutri P inhibitory action reached maximum efficacy at a dosage of 1 mg/ml: it was noncompetitive and completely reversible after washing the tissue for up to 60 min. The trial results also suggested that the intestinal tissues from guinea pigs were not damaged after being in contact with Silvafeed®.
Moreover, Silvafeed® Nutri P exerted other beneficial effects related to two contrasting actions in the proximal colon. Firstly, on one hand the tannins prevented the strong muscle contraction caused by the stimulation of neuronal serotonin-receptors within the gut. On the other hand, they did not interfere with the muscle relaxation caused by the direct stimulation of serotonin-receptors located in the proximal colon muscle. Therefore these results highlighted the selective inhibitory activity of Silvafeed® Nutri P.
Secondly, Silvafeed® Nutri P antispasmodic effect did not changed in the presence of probiotics such as Saccharomyces boulardii, which exert well-known benefits against various gastrointestinal disorders.
To summarise, Silvafeed® Nutri P was suitable for keeping gastrointestinal disorders under control thanks to its following properties:
* Antispasmodic effect
* Ability to relax the gut muscles without damaging the intestinal tissues
* Strong antibacterial and antiviral activities
* Synergistic efficacy with probiotics

References
Budriesi R., loan P., Micucci M., Micucci E., Limongelli V. and Chiarini A., 2010. Stop Fitan: Antispasmodic Effect of Natural Extract of Chestnut Wood in Guinea Pig Ileum and Proximal Colon Smooth Muscle. Journal of Medicinal Food, 13(5):1104-1110.
Lupini C., Cecchinato M., Scagliarini A., Graziani R. and Catelli E, 2009. In Vitro Antiviral Activity of Chestnut and Quebracho Woods Extracts against Avian Reovirus and Metapneumovirus. Research in Veterinary Science, 87:482-487.
Palombo E.A., 2006. Phytochemicals from Traditional Medicinal Plants Used in the Treatment of Diarrhoea: Modes of Action and Effects on Intestinal Function. Phytotherapy Research, 20(9):717-724.
Suroowan S., Javeed F., Ahmad M., Zafar M., Noor M.J., Kayani S., Javed A. and Mahomoodally M.F. 2017. Ethnoveterinary Health Management Practices Using Medicinal Plants in South Asia - a Review. Veterinary Research Communications, 41(2):147-168
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Authors:
Olivier Desrues
Silvateam
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Steffen Hansen
PIG.dk
24 de septiembre de 2017
Do you have any trials comparing the effect on animal performance of 2500 ppm ZnO with your product in post-weaning piglets?
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Olivier Desrues
Silvateam
19 de mayo de 2017
Dear Marco, very interesting point there. We have got feedback from farms that support your field experience. From the published reports, it seems that such combination is at least not detrimental; and in some cases can give good results (partly due to the additives or synergistic effects on bacterial populations in the gut, with less pathogenic species and more beneficials ones). But the possible combinations of types of tannins and acidifiers are numerous... and might not all give the same results. So to be continued
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Olivier Desrues
Silvateam
18 de mayo de 2017
Good luck with this. Also, be careful if you come across old literature - it may not give you a correct overview of tannin benefits. Once you get the right dose and tannin composition, you will see a lot of good things!
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Olivier Desrues
Silvateam
18 de mayo de 2017
Many thanks for your interest. First, the choice of an animal model for monogastrics was made to get some insights on the mechanisms of actions. For poultry we can expect very similar effect, which is also supported by our field trials.
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Eros baroni
27 de septiembre de 2017
I checked the site is this: https://actavetscand.biomedcentral.com/track/pdf/10.1186/1751-0147-52-19?site=actavetscand.biomedcentral.com Try also to find it on the site: https://actavetscand.biomedcentral.com/ I do not understand I have no problems finding it. good work and good luck.
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Eros baroni
25 de septiembre de 2017
I was inspired by this research and found interesting benefits as I wrote in a previous post. https://actavetscand.biomedcentral.com/track/pdf/10.1186/1751-0147-52-19?site=actavetscand.biomedcentral.com
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Eros baroni
21 de septiembre de 2017
Thank you sir. Desrues, I am very interested in the use of tannins and the various uses that can be made, even non-food use example quebracho tree tannins, for controlling and productions of compounds that cause manure odors, including hydrogen sulphide. I've read the studies ARS (USDA) scientists research and I hope the results obtained in vitro can be replicated in breeding.
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Olivier Desrues
Silvateam
21 de septiembre de 2017
Hi Marco, Good to see that you keep track of every possible use of tannins! Yes there are studies on hydrolysable tannins to reduce boar taint, but to my understanding they mainly look at the effect on hormones and enzymes that influence clearance of skatole. Bilic 2016, Agro Sustain. Dev 36:62 (DOI 10.1007/s13593-016-0399-1) Bee 2016, Animal 1:9 (doi:10.1017/S1751731116002597) my email: odesrues@silvateam.com
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Eros baroni
20 de septiembre de 2017
I use the tannins topic to ask a question: I have read that hydrolysed tannins can have an inhibitory effect on the total activity of the blind bacteria, an interesting aspect because this reduction could result in a lower microbial synthesis of cannula and indole, which is responsible for the smell of vermin intestinal tract of whole male pigs. Do you have any experiences or studies that can confirm this? Where can I find them? thank you
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Eros baroni
18 de mayo de 2017
I wanted to ask Dr. Desrues, I used the tannin in combination with organic and inorganic acids, in growing pigs, and I found an enhancement of the effects. Is it just my feeling on the field, or do you have any evidence that this happens, or is it a useless combination? Thank you for the reply.
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