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Swine enteric diseases

Enteric diseases, including ileitis, salmonellosis and porcine epidemic diarrhea (PED), are common gastrointestinal disorders that, if left untreated, can result in undernourished, dehydrated pigs and possible death. Pigs of all ages are susceptible to intestinal diseases, and diarrhea is the clinical sign common to nearly all such disorders. Infectious agents that cause enteropathies are typically transmitted via the fecal-oral route. More than 20 etiologic agents, including bacteria, viruses, and parasites, can cause primary intestinal disease in pigs. Some other viruses, including sapovirus, adenocirus, and enterovirus, also have been isolated from the intestines of pigs but are not associated with economically consequential disease. Pig diarrhoea is one of the most frequent health problem in modern production, which can be associated with high mortality, decreased growth rates and an increase in treatment costs. The solution for an enteric disease requires a diagnosis which is based on diagnostic criteria, that must be respected to be reliable. The veterinary practitioner has the responsibility of making a final diagnosis, and based on this to make decisions concerning the management of swine health problems. The veterinary diagnostic laboratory can be an important support providing technical assistance in performing laboratory testing and consultancy activity.
Introduction: Viral diarrhea severely damage pig industry, causing tremendous economic loss worldwide, especially during the porcine epidemic diarrhea virus (PEDV) outbreaks in recent years. The most common viruses causing diarrhea are PEDV, transmissible gastroenteritis virus (TGEV), and porcine rotavirus A (PoRV-A). In the past years, some new viruses like porcine kobuvirus (PKV) and porcine sapovirus (PoSaV) were discovered from pig intestinal contents. It is very difficult...
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Introduction: Porcine epidemic diarrhea (PED) is a highly contagious disease caused by porcine epidemic diarrhea virus (PEDV) infection, characterized by watery diarrhea, vomiting, dehydration, and weight loss in swine (1). PEDV has an enveloped, single-stranded, positive-sense RNA genome of ≈28 kb, belongs to the order Nidovirale, the family Coronaviridae, genus Alphacoronavirus (1). PEDV was adapted to serial propagation in Vero cell cultures by adding trypsin to...
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Gillespie
Rensselaer Swine Services
Introduction: The object was to determine if Zoetis’ conditionally licensed PEDV vaccine will enhance immunity in animals that were exposed to wild PEDV virus approximately 18 months prior. Materials and Methods: This project was performed from 7/20-9/8 2015 at a 2,200 sow breed-to-wean site that broke with PEDV in February 2014. The enrolled sows farrowed in August 2015 which is approximately 18 months post-infection. The study’s protocol used...
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Introduction: Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV) represent new threats to the swine industry. To aid in early detection of virus, monitor shedding, or differentiate viral species, real-time PCR has proven a useful diagnostic tool. The aim of this study was to measure the sensitivity of real-time PCR assays for the detection of PEDV and PDCoV on field samples at different times of the infection. Materials and...
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Marika Genzow
Boehringer Ingelheim
Introduction: Porcine Epidemic Diarrhea (PED) is a Coronavirus infecting pigs globally but most especially in Asia1,2,3. The outbreaks have been causing problems in Philippine commercial farms. This field trial was conducted to confirm the efficacy of a Modified Live PED Vaccine (Enterisol® PED) in a commercial farm under field conditions. Materials and Methods: The trial was conducted in a 500-sow farrow to finish farm in the North part of the...
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Luís Guilherme de Oliveira
UNESP - Universidad Estatal Paulista
UNESP - Universidad Estatal Paulista
Introduction: Bovine Viral Diarrhea Virus (BVDV) has cattle as natural hosts, but it can infect other animals, such as sheep, goat and swine. Once infected, pigs usually do not present clinical signals of infection, which can leads to a silence viral dissemination among animals. Furthermore, the transmission of BVDV between pigs and ruminants requires direct or indirect contact, but virus transmission among pigs remains unknown. Thus, the aim of this work was to evaluate the...
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Darin Madson
Darin Madson and 1 more
Iowa State University
Iowa State University
Introduction: This study examined the effects of feeding Bacillus subtilis C-3102 (Calsporin® Calpis Co. Ltd., Japan) at the target inclusion rates of 0 CFU/g, 500 000 CFU/g and 1 000 000 CFU/g on intestinal health in weaned pigs after challenge with Porcine Epidemic Diarrhea virus (PEDv). Materials and Methods: A two by three factorial design composed of three diets containing 0 CFU/g or 500 000 CFU/g or 1 000 000 CFU/g of Calsporin® and PEDv...
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Jens Peter Nielsen
University of Copenhagen ( DenmarK )
Introduction: Antimicrobial resistance testing of enterotoxic Escherichia coli (ETEC) is used as a diagnostic decision tool for selecting classes of antibiotics for treatment in pigs. Resistance testing is often done on isolates from faecal samples collected from diseased case pigs with the advantage of high certainty of analysing E. coli stains that has caused disease in the individual pig. The objective of this current study was to investigate pen-level...
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Introduction: Porcine epidemic diarrhea (PED) characterized by watery diarrhea and vomiting, was described throughout Europe till the end of the 1990’s and is caused by an Alphacoronavirus, the PED virus (PEDV). Since April 2013, a severe epizooty of PED has been striking USA previously free from this disease. Suckling piglets are the most affected by PED with up to 90-95% mortality. In China in 2010 and USA in 2013, PED epidemics were related to new PEDV strains....
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Introduction: After the first signals from the US about devastating PEDv infections in 2013, Europe was extremely motivated to prevent this virus crossing the Atlantic. A baseline study in the Netherlands, conducted in the second half of 2014, showed the naïve status of the Dutch pig industry for PEDv. In November 2014, after the first case of PED was confirmed by GD Animal Health, a PED taskforce, in which the government and all involved organizations in the Dutch pig...
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Introduction: The new porcine epidemic diarrhea (PED) outbreak has been documented in China since late 2010 and now with global distribution, resulting in enormous economic losses to swine industry. Autophagy is a highly conserved intracellular degradation process and be manipulated by some viruses for their benefits. Our previous proteomic data indicated that autophagy might participate in PEDV infection. However, the concrete role of autophagy is unknown. In the present study,...
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Peter Davies
Peter Davies and 1 more
University of Minnesota
University of Minnesota
Introduction: When pathogens become airborne, they travel associated with particles of different size and composition. Particle size determines the distance across which pathogens can be transported, as well as the site of deposition and the survivability of the pathogen. Despite the importance of this information, the size distribution of particles bearing viruses emitted by infectious animals remains unknown. In this study, we characterized the concentration and size...
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Danyel Bueno Dalto
Agriculture and Agri-Food Canada
Agriculture and Agri-Food Canada
Despite environmental and public health (bacterial resistance) issues, supranutritional levels of zinc oxide (ZnO) are still commonly used to prevent diarrhea in post-weaning piglets. In Canada, these levels represent more than eight-fold the CFIA proposed maximum levels at 300 mg/kg. The limited knowledge of their consequences for the metabolism of trace minerals has hampered the replacement of this strategy without compromising piglet health. Our laboratory has performed a series of...
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Mike Tokach
Mike Tokach and 1 more
Kansas State University
Kansas State University
Pharmacological levels of Zn in early nursery pig diets reduce the instance of post-weaning diarrhea and improve performance. However, there are growing concerns with pharmacological levels of Zn and much attention has been directed toward strategies to lower dietary Zn without negatively impacting performance. Diet acid-binding capacity-4 (ABC-4) could be an option to formulate low Zn diets. Dietary ABC-4 is the hydrochloric acid required to reach a pH of 4. The young pig has a limited...
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Yihang Li
University of Delaware
University of Delaware
Yihang Li (University of Delaware)      Developmental plasticity during the prenatal and early postnatal periods allows animals to adapt quickly to their environment and efficiently construct organ systems crucial for survival. These adaptations, which may be irreversible later in life, can lead animals to develop beneficial survival strategies or predispose them to chronic diseases. The gastrointestinal (GI) tract is a highly adaptive organ, contending...
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Nick Gallina
Purdue University (USA)
Purdue University (USA)
Nick Gallina (Purdue University)      Background: Enterotoxigenic Escherichia coli (ETEC) strains are the primary perpetrators of colibacillosis in piglets, resulting in mortality and agribusiness economic woes. ETEC expressing fimbrial antigens, F4 and F18, are the predominant contributors to colibacillosis. F4 is most prevalent in neonatal diarrhea. F18 is more common in post-weaning colibacillosis. Intestinal epithelial interaction and...
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Diana Ayala
Diana Ayala and 1 more
Agribrands Purina
Diana Ayala (Purina Animal Nutrition)     Post-weaning diarrhea (PWD) is a serious health and welfare problem for the global swine industry. PWD is a multifactorial condition occurring the first 10–14 d after weaning; it is generally associated with the proliferation of pathogenic Escherichia coli groups, specifically enterotoxigenic E. coli (ETEC); however, PWD is also associated with several viral infections. Antibiotics are commonly used as a control...
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Yihang Li
University of Delaware
University of Delaware
Yihang Li (University of Delaware) gives a presentation on the gastrointestinal tract and the impact of early life development on later life diseases in pigs, during the 11th Symposium on Gut Health in Production of Food Animals in St. Louis, USA....
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Nick Gallina
Purdue University (USA)
Purdue University (USA)
Nick Gallina (Purdue University) speaks on serotypes of E. coli in pigs, and presents studies aimed at developing more effective mitigation measures using cell models, during the 11th Symposium on Gut Health in Production of Food Animals in St. Louis, USA....
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Diana Ayala
Agribrands Purina
Diana Ayala (Purina Animal Nutrition) presents research to determine the underlying bacterial cause of PWD and a potential vertical transmission from sows to pre-weaned piglets, as well as to determine whether a customized direct-fed microbial (DFM)-based product could reduce the pathogens isolated from affected pigs, during the 11th Symposium on Gut Health in Production of Food Animals in St. Louis, USA....
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