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Swine enteric diseases

Enteric diseases, including ileitis, salmonellosis and porcine epidemic diarrhea (PED), are common gastrointestinal disorders that, if left untreated, can result in undernourished, dehydrated pigs and possible death. Pigs of all ages are susceptible to intestinal diseases, and diarrhea is the clinical sign common to nearly all such disorders. Infectious agents that cause enteropathies are typically transmitted via the fecal-oral route. More than 20 etiologic agents, including bacteria, viruses, and parasites, can cause primary intestinal disease in pigs. Some other viruses, including sapovirus, adenocirus, and enterovirus, also have been isolated from the intestines of pigs but are not associated with economically consequential disease. Pig diarrhoea is one of the most frequent health problem in modern production, which can be associated with high mortality, decreased growth rates and an increase in treatment costs. The solution for an enteric disease requires a diagnosis which is based on diagnostic criteria, that must be respected to be reliable. The veterinary practitioner has the responsibility of making a final diagnosis, and based on this to make decisions concerning the management of swine health problems. The veterinary diagnostic laboratory can be an important support providing technical assistance in performing laboratory testing and consultancy activity.
Chris Rademacher
Iowa State University
Iowa State University
Introduction: The main impact of Porcine Epidemic diarrhea (PED) virus is high mortality in piglets between birth and weaning and as a consequence pig producers have serious economic losses. Since 2014, Mexico has been positive to PED virus as diagnosed by the PCR test. Materials and Methods: The aim of this study was to assess the effect of two vaccines against PED (manufactured by ZoetisTM and Harrisvaccines TM respectively) compared to no...
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Ivan Hernández Caravaca
Boehringer Ingelheim
Introduction: Lawsonia intracellularis (L.i.) is the causative agent of porcine proliferative enteropathy (PPE). PPE is a relevant economic enteric disease that causes diarrhea and reduces weight gain in growing pigs (1). The subclinical form produces as well a negative impact on performance and farm economics. L.i is endemic in most of the Spanish farms (2). The aim of this study was to evaluate the efficacy of Enterisol® Ileitis (Boehringer Ingelheim Vetmedica...
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Introduction: Senecavirus A (SVA) is an emerging picornavirus that has been associated with outbreaks of vesicular disease and neonatal mortality in swine. Vesicular disease with unknown etiology and clinically indistinguishable of other vesicular infections have been reported in U.S, Canada and recently in Brazil. Here, we present an outbreak investigation conducted in swine herds showing an increased neonatal mortality and vesicular disease that have been associated to...
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Introduction: Porcine kobuvirus with single-stranded RNA genome, also known as Aichivirus C, belongs to the family Picornaviridae. This virus was identified for the first time in Hungary in 2008. The virus was also identified in pigs of several countries with prevalence variation from 3.9 up to 100%. Virus was detected in healthy and diarrheic pigs, often with higher prevalence in diarrheic piglets. In our work we describe the detection of porcine kobuvirus in pigs of different...
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Tim Snider
PIC Genetics
Introduction: PEDV and PDCoV entered the US in 2013 infecting 56% of the sow herds. The PIC multiplication system totaling 92,000 sows in North America had accumulated a record of minimal impact from PRRS or M. hyopneumoniae in past years; but from November 2013 to April 2014, 47% of the breeding herds became infected with PEDV and/or PDCoV. Likely because of their remote location and biosecurity, none of the genetic nucleus or sire line nucleus farms were affected. This...
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Nicholas Gabler
Iowa State University
Iowa State University
Introduction: In pigs, PEDV causes reduced growth performance, villus atrophy, and impairment of intestinal barrier function and integrity. The objective of this study was to determine the extent to which a PEDV challenge alters jejunum morphology, epithelial apoptosis, crypt cell proliferation, and tight junction proteins over a 14-day infection. Materials and Methods: Thirty-two mixed-sex Choice Genetics maternal line approximately 4 weeks-of-age...
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Introduction: Porcine epidemic diarrhea virus (PEDV), a member of the genera Alphacoronavirus in the family Coronaviridae, causes an acute and highly contagious enteric disease characterized by severe enteritis, vomiting, watery diarrhea and high mortality in seronegative neonatal piglets. In the last years, PED caused significant economic losses in swine industry in Asia and United States and since 2014, PEDV has also re-emerged in Europe. Two main PEDV variants...
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Introduction: A new strain of Porcine Epidemic Diarrhea virus (PEDv) occurred in the Republic of Korea in November 2013 and continues to impact the swine industry up to now. The new strain was sequenced and the results showed that the spike protein gene of this newly prevalent PEDv is 99.64%~99.81% homologous to the PEDv isolated in USA from 2013 to 2014. CAVAC acquired ISU46065IA13 strain (genotype 2a), a field isolate by Iowa State University, USA, and developed a new...
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Introduction: Porcine Epidemic Diarrhea (PED) is caused by PED virus (PEDV) that is a member of the order Nidovirales, family Coronaviridae and genus Coronavirus. PED is a severe enteric disease that causes economic losses worldwide. Maternal passive immunity can prevent losses in suckling piglets during the period of immature immune system. Sow colostrum is the most abundant and easily accessible resource of a farm. The aim of this study was to evaluate an immunological...
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Introduction: Since late 2010, new variants of porcine epidemic diarrhea virus (PEDV) have arisen in China, spread to Asia and North America in the end of 2013, and cause severe watery diarrhea in pigs of all ages and extremely high mortality rate in neonatal piglets resulting in significant economic losses. Recent studies indicate that the spike (S) gene of Taiwan new PEDV strains are closely related to global non-S INDEL PEDVs but significantly different from historic...
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Introduction: Objectives 1) Determine the sow serum-neutralizing antibody titer (NABT) baseline status and response from a 2 dose blanket vaccination of Zoetis’ conditionally licensed PEDv vaccine in both a naïve population, and a farm previously exposed to PEDv. 2) Determine the NABT level expressed in colostrum and milk after triple vaccination in these farms. Materials and Methods: A historically naïve (Farm A) and a...
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Cesar Corzo
Cesar Corzo and 1 more
University of Minnesota
University of Minnesota
1. Introduction Porcine epidemic diarrhea (PED) is a swine enteric viral disease first documented in the United States (U.S.) swine population in 2013, at which time it sparked a major epidemic [1]. The clinical presentation involves high morbidity and mortality in suckling piglets with diarrhea being the main clinical sign [2, 3]. The disease is caused by a virus (PEDV) in the genus Alphacoronavirus [4] that is largely classified into two main genogroups, the S-INDEL strain and...
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Introduction: Owing to inexperience with Porcine Epidemic Diarrhea (PED) but building on experience with Transmissible Gastro-Enteritis (TGE), North American producers utilized various methods of whole-herd exposure and sanitation to eliminate PED virus from sow herds. Compared to continuous farrow flows, elimination was easier in group-mating systems due to the inherent break in piglet ages/flow. Age-segregated flows with movement at weaning to off-site nurseries were easier...
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Introduction: Porcine epidemic diarrhea virus (PEDV) belonging to the Group I coronavirus is the major cause of lethal diarrhea disease in piglets. In recent years, there are many case reports of PEDV infection in pigs in China and caused large economic losses. To better control this disease, it’s necessary to explore the epi demiological status and genomic characteristics of the new PEDV isolates. Materials and Methods: Fifty five feces samples of...
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Introduction: In the Netherlands antibiotic use in human health care and in food-producing animals is a concern for the Dutch society and the Dutch government. The use of antibiotics is controlled by law and the consequence is a strict monitoring in the diagnostics of diseases including laboratory tests to confirm disease and treatments. The message of the Dutch government is simple: use less antibiotics in animals. In this survey, we demonstrate how in a finishing farm...
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Federico Giannitti
UC Davis - University of California
UC Davis - University of California
Introduction: Gastrointestinal disease is one of the leading causes of clinical signs in growing and finishing pigs. We herein describe several diagnostic cases of finisher pig colitis wherein both novel and common pathogens were discovered. Materials and Methods: Necropsies of 5 pigs, 10-13 weeks of age, with diarrhea and weight loss, were performed at two swine farms, each housing > 15,000 growing pigs. Tissue samples including colon were submitted to the...
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Yuzo Koketsu
Meiji University
Introduction: The first outbreak of porcine epidemic diarrhea (PED) since 1996 in Japan was reported in October 2013. Also, in August 2014, Japan also had the first outbreak of dengue fever (DF) since 1945. A concern with these recent incidents is the risk of a decrease in pork consumption due to misinformation or exaggeration by the news media. Therefore, our objectives were to characterize PED and DF newspaper and google-searched articles, and identify important text...
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Introduction: Viral diarrhea severely damage pig industry, causing tremendous economic loss worldwide, especially during the porcine epidemic diarrhea virus (PEDV) outbreaks in recent years. The most common viruses causing diarrhea are PEDV, transmissible gastroenteritis virus (TGEV), and porcine rotavirus A (PoRV-A). In the past years, some new viruses like porcine kobuvirus (PKV) and porcine sapovirus (PoSaV) were discovered from pig intestinal contents. It is very difficult...
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Introduction: Porcine epidemic diarrhea (PED) is a highly contagious disease caused by porcine epidemic diarrhea virus (PEDV) infection, characterized by watery diarrhea, vomiting, dehydration, and weight loss in swine (1). PEDV has an enveloped, single-stranded, positive-sense RNA genome of ≈28 kb, belongs to the order Nidovirale, the family Coronaviridae, genus Alphacoronavirus (1). PEDV was adapted to serial propagation in Vero cell cultures by adding trypsin to...
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Gillespie
Rensselaer Swine Services
Introduction: The object was to determine if Zoetis’ conditionally licensed PEDV vaccine will enhance immunity in animals that were exposed to wild PEDV virus approximately 18 months prior. Materials and Methods: This project was performed from 7/20-9/8 2015 at a 2,200 sow breed-to-wean site that broke with PEDV in February 2014. The enrolled sows farrowed in August 2015 which is approximately 18 months post-infection. The study’s protocol used...
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