Mycotoxin-deactivator:In vitro or In vivo, How should we choose?

Dr. Marchenkov, in relation to your question on binders binding vitamins, please keep in mind that today customers are using maximum of 2 kg per ton of feed toxin binder. I won't recommend anything more than that. At such levels of inclusion, vitamin binding is zero or very minimal. 70% of the global feed today contains one or other mycotoxin binder. Very rarely we get questions from customers on nutrient binding. There was a time when customers were using 5 kg per ton clay binders. Those days are gone. More than nutrient binding, the customers need to evaluate technical dossier of the product related to in vitro or in vivo binding as well as performance benefits. Research has shown significant impact of almost all the mycotoxins on gut and immune systems in animals. We need to make sure the product helps in reinstating these organ systems. Mycotoxin binding concept alone will not help to manage all the mycotoxins we know today. I hope this helps. Regards, Swamy

For poultry we should choose In Vivo. However for ruminants, we should try both In Vitro as well as In Vivo. Dr Ram Singh Bibyan

For poultry, I have formulated two mycotoxin binders namely Mycodetox B1 and Mycodetox B2 based on my decade's research on chickens, quails, turkeys and ducks. Both the binders ameliorated the adverse effects of aflatoxicosis in poultry and are equally efficaceous in ameliorating aflatoxicosis in these poultry species. Dr. Ram Singh Bibyan

Dear All It is surprising that in 2022 we are making questions that were resolved in 1987 /1988 In vitro trials will never prove that a product will work in vivo. This was proven in 1988 with Activated Charcoal it captured 100% of the mycotoxin in vitro but it did not work in vivo protecting the target organ. Deactivation - Biotransformation - Adsorption The best explanation is the rumen of a cow. A rumen can biotransformation and/or deactivate mycotoxin as long as you have perfect conditions When stress, acidosis, use of antibiotics, bacterial infections, not well balance feed ocurre this biotransformation / deactivation is reduced significantly. In the case of adsorption the same way that the clay comes in the same way that the clay com out and it is not affected by conditions in the GI tract. The key factor on adsorption is the quality , type and process that is done to the clay so it is capable of adsorbing one and or multiple toxins. Also you need to differentiate products that reduce the secondary effect caused by a mycotoxin vs product that by adsorbing the mycotoxin are capable of Protecting the Target organ that the mycotoxin affects. This is the only way to differentiate true mycotoxin binders vs hepatoprotections , immunomodulators, probiotics that improve productivity parameters but do not protect the target organs. etc.

Dear all, at first we need to select: what is deactivation? Is it destroying? Or binding? Or we need to know how effective is liver P-450 in vivo against mycotoxins? How can we use binders if these binders can chemically react with vitamins? What is alternative? Grain without mycotoxins: is it possible? Probably not, and this is problem for everybody. Let's discuss!

Hi. I think the best toxin binder : 1- High absorption power 2-High degree of purity 3-price is right 4- less side effects on host health