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Bacillus subtilis to prevent a pro-inflammatory response in an induced inflammation condition in broilers

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June 25, 2019

I think DFM can play an important role as dietary alternatives to antibiotics and our work also supports this finding that certain strains of bacillus modulate host inflammatory responses and intestinal barrier gene expression of commercial broilers subjected to LPS challenge. Intestinal transcriptomic analysis indicated that B. subtilis-based probiotics differentially regulate intestinal immune and tight junction protein mRNA expression during states of LPS-mediated immunological challenge. (Res Vet Sci. 114:236-243. 2017.)

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June 25, 2019
There will be an International Symposium on Antibiotic Alternatives in Bangkok in December 16-18, 2019 and many different antibiotic alternatives including Bacillus DFM will be discussed. Check https://www.registration-master.com/isata3rd/content.php?slug=program.
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June 25, 2019
Several strains of Bacillus subtilis have shown the ability to dampen the inflammatory response in broilers. These trials were performed both in normal temperatures and in high temperatures. Bacillus subtilis is certainly to be considered when heat stress is expected.
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June 25, 2019
I believe that not all strains of Bacillus will dampen heightened host immune response so we need to screen different Bacillus isolates using in vitro assays and follow with in vivo chicken trials to measure local cytokine gene expression in the gut using PCR or antigen-capture assay.
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