Bovine respiratory disease (BRD) is the most significant health problem of the beef industry which affects the lower respiratory tract / lungs or upper respiratory tract. It can manifest when cattle stress levels are raised due to weaning, shipping, processing, adverse weather, and overcrowding and this compromises the defense mechanisms of the immune system. Since it is always more convenient to focus on prevention than treatment, BRD vaccines are one of the tools needed to control this disease. What should be considered when choosing the right vaccine and which would be the best way to administrate them?