Effects of Fermentation Product of S. cerevisiae XPC™ in Chicken Diets on Resistance against Infectious Bronchitis Virus
Published:August 12, 2015
By:Cassandra Breedlove*, Aly Ghetas, Stephen Gulley, Frederick van Ginkel, Kellye Joiner, Vicky van Santen, Haroldo Toro Auburn University, Auburn, AL, USA.
The commercial Saccharomyces cerevisiae fermentation product XPC™, often used as feed additive in poultry production, has been associated with enhanced immune functions. We evaluated immune responses and protection after IBV challenge in naïve and infectious bronchitis virus (IBV)- vaccinated specific-pathogen-free white leghorn chickens (groups n=50 each) receiving XPC at feed-additive concentrations of 2 lb/ton or 3 lb/ton.
Naïve chickens receiving XPC and challenged at 21 days of age showed reduced respiratory signs and a tendency of less histological damage in the trachea 5 days after challenge. Treated birds also showed increased IgA+ and CD44+CD8+ lymphocytes in the spleen 10 days after challenge. Viral load in the trachea, serum IBV antibody levels, and numbers of splenic CD3+/CD8+ and CD3+/CD4+ lymphocytes did not show significant differences between treated and untreated challenged controls. In experiment 2, birds received the same XPC treatments but were vaccinated with a live attenuated IBV vaccine at 10 days of age and subjected to homologous challenge at 25 days of age. Evaluations performed 5 days after challenge showed reduced adverse respiratory reactions and significantly increased IgM+ and IgA+ lymphocytes in the Harderian gland in XPC treated chickens.
XPC-treated chickens also showed significantly increased serum IBV antibody levels 20 and 27 days post challenge. Tracheal histopathology and viral load, and numbers of spleen CD44+ and CD3+ cells did not differ significantly between treated and untreated challenged controls. Some of the differences in response to IBV vaccination and/or challenge observed between XPC-treated and untreated chickens provide evidence for a beneficial effect and thus merit further study.
Secondary colibacillosis due to primary viral respiratory infection generally sets in about 10 days after primary viral infection and once you see the symptoms at post-mortem, treatment can only be with antibiotic, but recovery may not be 100% as severity in each bird varies. Doing a sensitivity test on culture can better allow the selection of an effective antibiotic. Meanwhile if possible add vit B12 in water to stimulate intake. Using vaccines to control IB is a better solution for future flocks.
How to control secondary colibacillosis after IB, Became more of an issue than the IB itself. I am Badly Suffering due to secondary infection this 4th broiler flock hit by IB. IB is cure but secondary colibacillosis make my bird crazier, specially suffering due to e-coli and bird reduce the feed intake Please advise me how to treat Boiler Bird. Regards Aftab Anwar.
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