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Impact of DON on broiler gut health
Published: May 31, 2023
By: Life Rainbow Biotech
Deoxynivalenol (DON) is a major mycotoxin from the trichothecene family of mycotoxins produced by Fusarium fungi that cause disease in grains. Food and feed contaminated with DON cause a variety of adverse health effects in humans and farm animals.
Fifty-four one-day-old broilers (Ross 308) were randomly allocated to three different treatment groups (n = 18 per group):
Results showed that the villus height was significantly reduced in the duodenum of the DON treatment group compared with the control group while the antidote alleviated the damage caused by DON. A similar effect was observed in the ratio of villus height and crypt depth (Table 1).
In feeding experiments, the villus height and the ratio of villus height and crypt depth were reduced in the duodenum of DON-fed broiler chickens, whereas mycotoxin degradation enzymes efficiently reversed the abnormal morphology of the small intestine in the DON-fed broilers. This effect was alleviated in the presence of mycotoxin degradation enzymes. DON produced in solid-state fermentation can cause toxic effects in broilers and induce an abnormal morphology of the small intestine, particularly the duodenum.
Life Rainbow Biotech has 17 years of research on mycotoxins and has developed a new type of detoxify mycotoxin product, mycotoxin degrading enzymes-Toxi-Free PLUS®, consists of three different types of enzymes in one product which specific activity to convert mycotoxins such as DON into nontoxic to reduce the toxicity caused to animals. Toxi-free PLUS® is a specially designed feed additive to protect animals' health by counteracting mycotoxins through multiple strategies, which include mycotoxin degrading enzymes, selected-adsorbent, and herb extract, proven to be effective and specific in farm trials and scientific trials.
References
Yu Y. H., F. S. H. Hsiao, W. S. Proskura, A. Dybus, Y. H. Siao, Y. H. Cheng. 2018. An impact of Deoxynivalenol produced by Fusarium graminearum on broiler chickens. J. Anim. Physiol. Anim. Nutr. 2018, 102, 1012–1019.
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Sanluc International nv
17 de junio de 2023
I wonder if I am reading the data from the experiment correctly. ?
For the JEJUNUM, I see the VH/CD ratio of the DON+treatment is worse than the DON alone group and the negative impract (7,8 -> 7,4) is much larger than from DON alone (7,9 -> 7,8); If my interpretation would be correct, than this is very bad, since it looks that the product is aggravating the situation.
Also in the DUODENUM there is no significant difference between DON alone and DON + product. And a negative effect on the CD is a bad indication (inflammation)
What about the effects on ILEUM, which is of course the most important segment of the small intestine ? From our multiple trial work at many institutes and universities, it looks like that only the absorbent is having some limited effect, the other ingredients not.
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