Mycoplasma, Use of Antibiotics and Alternatives

Strict biosecurity and all-in-all- out is best for Mycoplasma prevention. Antibiotic such as erythromycin, tiamulin. tetracyclines are used to alleviate clinical signs and reduce production losses. Mycoplasma gallisepticum may develop resistance against used antibiotics. Killed vaccines are used to breeder farms against Mycoplasma.

Hello Dr. Chris Morrow

I did the MG Ts11 vaccination at the Farm Broiler Breeder at 28 days of age.
Before vaccination, I gave prevention MG with Tylmicosin for 5 days.
The distance between treatment and MG Ts11 vaccination It was 5 days and 10 days.
The Amean description of ELISA MG titer, 6 weeks after vaccination is as follows:

A. Distance between administration of Tylmicosin and MG TS11 vaccine for 5 days.

Shed1, Amean 198, Cv% 205, Serum no: 18, Neg: 17, Post: 1,% Post: 6
Shed2, Amean 320, Cv% 98, serum no: 19, Neg: 16, Pos: 3,% Pos: 16
Shed3, Amean 33, Cv% 209, Serum no: 18, Neg: 18, Post: 0,% Post: -
shed4, Amean 82, Cv% 161, Serum no: 18, Neg: 18, Post: 0,% Post: -
shed5, Amean 40, Cv% 200, Serum no: 18, Neg: 18, Post: 0,% Post: -
shed6, Amean 70, Cv% 221, Serum no: 18, Neg: 18, Post: 0,% Post: -

B. The distance between Tylmicosin administration and MG TS11 Vaccination for 9-10 days.

shed7, Amean 691, Cv% 79, Serum no: 19, Neg: 10, Post: 9,% Pos: 47
shed8, Amean 942, Cv% 80, Serum no: 18, Neg: 7, Post: 11,% Pos: 61
shed9, Amean 790, Cv% 59, Serum no: 18, Neg: 10, Post: 8,% Pos : 44
shed10, Amean 767, Cv% 61, Serum no: 18, Neg: 8, Post: 10,% Pos: 44
shed12, Amean 943, Cv% 63, Serum no: 18, Neg: 6, Post: 12, % Pos: 67

there are several questions namely
1. Is the distance between the administration of Tylmicosin and the MG Ts11 vaccination for 5 days too close so that the % positive result is zero.
2. Is the withdrawal time of tylmicosin in the bloodstream for 5 days is not enough, thus killing the MG Ts11 vaccine.
3. Will it be at risk for MG field challenges because the MG TS11 titer is very low
4. Is it necessary to repeat vaccination in cages 1-6 for MG Ts11 or just take serum for the second ELISA test to know development Titer .

Ask for advice and opinions from all experts and experienced for these problems.
Thank you very much.

Good topic, i am very interested.

Yes. That's an interesting topic. How can I control Mycoplasma?