Struggling to control Streptococcus suis disease in the context of antibiotic reduction

Published on: 08/26/2021
Author/s : Marcelo Gottschalk / Research Group on Infectious Diseases of Production Animals; Swine and Poultry Infectious Diseases Research Center; Faculty of Veterinary Medicine, University of Montreal, St-Hyacinthe, Quebec, Canada.

Introduction Streptococcus suis (S. suis) is a major porcine pathogen responsible for important economic losses to the swine industry. In fact, it is one of the main causes of bacterial death in post-weaned piglets, from 5 to 10 weeks of age. According to the Canadian Swine Health Information Network, S. suis-related diseases are the most common infectious problem reported in Canad...

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August 26, 2021
In weaning, after a first phase where innate immunity through phospholipase2A is activated, the inflammatory process follows after 5-7 days through type 2 microfold (M2) an immunorepression of inflammatory cytokinins and activation of Treg cells with an increase of Il 10, then a decrease of neutrophil granulocytes and phagocytosis. At the same time at the microbiome level there is a decrease in bacterioides and an increase in firmicutes (lactobacilli and clostridiacae). Since the clinical manifestations of Streptococcus suis infection often occur after the first post weaning week, is a link possible?
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September 1, 2021
I would be interested to see the results of a comparative analysis of the microbiome of piglets given antibiotics, versus controls and the incidence of S. suis in these two groups.
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Casey Bradley
Casey Bradley
Doctorate - Animal Science - Monogastric Nutrit...
  Springdale, Arkansas, United States
 
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