yujun qiu

Dear @luciano Pinotti thank you, I completely agree with you. When it comes to the bioavailability of naturally occuring choline, according to literature it may be 100% in corn, but 60-75% in SBM; I considered 50% a safe assumption. I believe we are all aware of the different roles of the individual components involved in methylation, and we know that these are not physiologically isolated from ea ...

I see a lively discussion developed on this topic but would not agree. I can of course understand position of @Ana as a representative of a betaine producer. Still, the argumentation chain is as follows:1) there is no methyl group needed for uric acid formation and no direct involvement of methionine nor betaine in this process. 2) betaine cannot transfer the methyl group to the creatine formation ...

Betaine Is Not Merely a Substitute for Methionine1. Unique Function: An Irreplaceable "Osmotic Regulator"The most distinctive feature setting betaine apart from other methyl donors (such as methionine and choline) is its unique role as an osmotic buffer.Core Anti-Stress Mechanism: When intestinal cells (especially during summer heat stress or diarrhea), liver cells, and kidney cells face high-osmo ...

Interesting discussion and great batting by both sides for their respective 'teams'. As a casual observer, some of the statements seem a little too absolute and imply that these compounds behave in linear, siloed, non-interacting ways in the body. Betaine clearly cannot replace methionine as an amino acid, but that does not mean it cannot spare dietary methionine. Methionine and potentially betain ...