Stefano Calamanti

In weaning, after a first phase where innate immunity through phospholipase2A is activated, the inflammatory process follows after 5-7 days through type 2 microfold (M2) an immunorepression of inflammatory cytokinins and activation of Treg cells with an increase of Il 10, then a decrease of neutrophil granulocytes and phagocytosis. At the same time at the microbiome level there is a decrease in ba ...

The beginning of the piglet intestine inflammatory process begins with the production of phospholipase 2A (PLA2). Following activation dentritche cells and macrophages IL 2 and granulocyte netrofili arrival in the basal lamina with release of ROS. Simultaneously, the dysbiosis following the food change involves a dell'immunotolleranza stopping and thus also provides you with an inflammatory proces ...

The interesting figure is in Table 1: Sow weight loss%, where P2 fat decreased more in Low Fa than in High FA sows.Result: higher efficiency of glucose metabolism lower energy demand from adipose tissues in High FA sows.Suggestion supplement the diet with carnitine, inositol, propylene glycol.

It is certain that amino acids modulate the immune system via General controlled nonrepressed (GCN2). The quantity of amino acids but above all the composition of the amino acid profile activate or repress the immune response. The BCAA amino acids, especially leucine, activate mTOR and repress GCN2, thereby increasing the inflammatory process in the intestine, which is of particular importance in ...

The immunotolerant action through the microbiome is also interesting as it allows Lactobacillus Alistipes to use tryptophan as an energy source. The product of this degradation is indoleamine 2-3 dioxygenase 1 which in turn activates the Ahr receptor (Aryl Hydrocarbon Receptor) whose activation allows the production of IL 22, IL 10.