I made a clinical diagnosis of CIAV January 2021-for first time in Kenya. Awaiting for laboratory confirmation. Major hatcheries vaccinate ,and the combination with CIAV+ rHVT would be a good achievement in disease prevention.
Regarding recombinant vector CIAV vaccine construction rHVT to be used as a hatchery vaccination , no success yet, inserts expression cassettes VPs , no in vivo expression.Investigation using the CRISPR/Cas9 tool may be a possible solution to generate in the future rHVT/CIAV.
Thanks you for revision and update on such a sturdy/hardy virus. Up to what extent is it true that the CIAV will not be vertically transmitted to the off-springs if their parents contain optimum level of antibodies against the same virus?