Dietary Allium hookeri reduces inflammatory response and increases expression of intestinal tight junction proteins in LPS-induced young broiler chicken
Published: February 9, 2021
By: Youngsub Lee 1, Sung-hyen Lee 2, Ujvala Deepthi Gadde 1, Sung-taek Oh 1, Sung-jin Lee 3, Hyun S. Lillehoj 1. / 1 Animal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD, USA; 2 National Institute of Agricultural Sciences, Rural Department Administration, South Korea; 3 College of Animal Life Sciences, Kangwon National University, Chuncheon 200-701, South Korea.
Summary
Highlights
• Increased α-1-AGP levels in serum by LPS challenge was significantly reduced by AH root or fermented root (1 and 5%) supplementation.
• Up-regulated pro-inflammatory cytokines (IL-1, Il-6, IL-8, TNFSF15, LITAF) in small intestine by LPS challenge were significantly down-regulated by AH root or fermented root (1 and 5%) supplementation.
• Reduced expression levels of tight junction proteins (JAM2, Occludin) and MUC2 by LPS challenge were reversed by AH root or fermented root (1 and 5%) supplementation.
Abstract published in Research in Veterinary Science 112 (2017) 149–155. http://dx.doi.org/10.1016/j.rvsc.2017.03.019.
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