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Protective matrix of acidifier for sustainable acidification in poultry to overcome antibiotic resistance

Published: December 14, 2022
Introduction High levels of production and efficient feed conversion are the need of the modern livestock industry which to a certain extent could be achieved by using specific feed additives. Feed additives are of great interest in the poultry industry due to their property to promote growth and performance. Common feed additives used in poultry diets include antibiotics, antioxidants, emulsi...
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Sumit Sipany
ABTL Advanced Bio-Agro Tech Ltd
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Sumit Sipany
ABTL Advanced Bio-Agro Tech Ltd
10 de junio de 2023

The organic acids and their salts or simply acidifiers play an important role in gut health in animals. The acidifiers could be used to favourably manipulate the intestinal microbial populations, improve the immune response, and perform a bactericidal activity in countering pathogenic bacteria. Acidifiers also improve the digestibility and absorption of nutrients. However, their effect will not be similar among all types of organic acids as their mechanism of activity is based on its pKa value.
Acidifiers with their potent applications helps in improving nutrient digestibility, mineral utilization, meat quality, enhancing immunity, antimicrobial effects in countering pathogenic bacteria, boosting performance and production, and thus safeguarding health of birds.

Use ACIPLEX product of ABTL for optimized acidification to amplify growth performance of birds.

1. A synergistically acting combination of organic acids and acid salts having non-corrosive and non-stringent properties.
2. Innovative acidifier, consisting of organic acids in a protective matrix that reduces the solubility of the acids, ensuring that they are released throughout the entire gastro-intestinal tract.
3. Safe and easy handling as well as fast and homogenous mixing in the feed.
4. No development of antibiotic resistance.
5. No withdrawal time.

Luc Goethals
Sanluc International nv
16 de julio de 2023

Thanks for this information, interesting, but revealing a lot of questions or request for more detailed information.

1) Could you document the synergism between the organic acids and salts you are using in your product? Meaning each time the individual effect at the used level and then the various combinations?
2) What is the dosage you recommend and what is the level and concentration you are reaching in the small intestine via your protective matrix system?
3) Since the ingredients are protected and not soluble, does this mean that the product has no single activity in the feed and the stomach. Acidification of feed and stomach is essential.

Dr. Rajendra Prasad Vemana
ABTL Advanced Bio-Agro Tech Ltd
21 de julio de 2023

Luc Goethals 1. Historically, the use of chemicals (acids and their salts) in feed conservation is a tried-and-true method used to protect stored feed and byproducts from bacterial, mold and yeast contamination

a) Product information of each product component is company specific based on internal research.

2. Aciplex dose is 1 to 4 kg for ton of feed based on raw materials used and most of the concentration will be reaching small intestines.

3. Animal feed preservatives based on organic acids usually include propionic acid and formic acid in formulations.

a) Experimental evidence supports Propionic Acid being a cost-effective choice for feed preservation.

b) Formic acid has been added to poultry diets as a means to limit Salmonella spp. and other foodborne pathogens both in the feed and potentially in the gastrointestinal tract once consumed.

Luc Goethals
Sanluc International nv
21 de julio de 2023

Dear Dr. Rajendra,

Thanks for your adequate feedback and clarifications.

I can't more than agree with some of your statements such as the feed preservation efficacy of propionic and formic acid: in fact "decontaminants" rather than "organic acids". And for sure, since decennia most industrial preservatives have been based on propionic and formic acid and their salts and are abundantly used. But these had always to be in "available" and "reactive" form. If out of the 1 to 4 kg dosage the majority will reach the intestine, then the decontamination effect in the feed, stomach might be neglectable.

Indeed formic acid with strong biocidal effect has been used to decontaminate raw materials and feed from pathogens, also for Salmonella, but once again all in active unprotected form and at significantly higher dosages. While the scientific world has come to a consensus that formic acid in the G.I.T. is promoting gene expression, attachment and invasion of Salmonella. It's easy to surf on internet for those publications. The last thing one should consider is to bring formic acid in the intestine. On top at the higher (intestinal) pH, formic is no more anti-bacterial (Lückstadt et Al)

Thanks for answering 2 of my 3 questions, the first one remaining open. During my 40+ years of professional career, I never came across a scientific study documenting synergy between organic acids and salts, the maximum obtained was some additivity.

Joshua A. Jendza
24 de julio de 2023
Luc Goethals Thank you for your pushback against overly optimistic marketing language. Synergy is a word often used, but an effect rarely demonstrated in organic acid trials. Additivity is far more common. This is becuase for most organic acids, the mode of action is the same, and the pH of the environment in which the acids are expected to operate are either too high or too low to allow for the differences in pKa between acids to amount to much in terms of net effect on microbial counts. The benefits to acid blends have more to do with which microorganisms you are trying to control, than with any interactions between the acids when acting against the same microorganisms. Formic acid is the most potent against salmonella, for example. When we combine formic acid with propionic acid, we are looking to expand our effect from controlling Salmonella to controlling Salmonella AND Molds. Each acid has a different area in which is it the most appropriate, and combinations are about combining areas of acid effect. Salts, on the other hand, are about balancing efficacy and handling properties. The purse salts are no longer acidic, and far less effective than the pure acids interns of their antimicrobial effects, but they do make the materials safer to handle for people, equipment, transportation, etc. And partial buffering can result in a product with much more desirable handling properties while still retaining the majority of the efficacy of the pure acid. Salts do NOT potential the acid effect into the intestine, or any of the other such nonsense we see in marketing literature. After all, organic acid absorption in most species begins BEFORE the intestine, and salts rapidly dissociate into their respective anions and cations once dissolved in the fluids of the digestive tract.
Luc Goethals
Sanluc International nv
25 de julio de 2023
Thanks for the valid and professional input. I do fully agree.
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