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Simulated Digestion System for In Vitro Feed Digestibility

Published: February 9, 2026
Summary
WHY IN VITRO METHODS MATTER Traditionally, diet formulation has relied on in vivo trials to determine digestible and metabolizable energy. These trials are accurate but slow, costly, and raise ethical concerns. Existing in vitro systems, meanwhile, are often too simplistic or poorly standardized to replace live-animal trials. Simulated Digestion System (SDS III) changes this. Developed over mor...
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Authors:
Shukun Yu
BioVinnova AB
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Akbar Yaghobfar
12 de febrero de 2026

How did you simulate the effects of energy and metabolic nitrogen in excreta and endogenous urine (in vivo) on protein digestibility and metabolic energy, or metabolizable energy? Recuse about 30 to 40 percent of ME losses.

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