Influence of Mycotoxins and a Mycotoxin Adsorbing Agent on the Oral Bioavailability of Commonly Used Antibiotics in Pigs

I would like to thank the authors for publishing this article and propose yet another mechanism behind increased antibiotics bioavailability in the presence of yeast-derived glucomannans. It is known that yeast produce biosurfactants (sometimes up to 120 g/l (Casas J.A. 1999)); in my research I observed that water extracts of a glucomannan-based “mycotoxin binder” exhibited properties of surfactant solutions – produced foam upon shaking, interfered with dye adsorption, washed off dye stains on paper. The ability of natural and synthetic surfactants to act as penetration enhancers is well known (Pandey A. 2014, Moghimipour E. 2015). P.S. It is amusing to contemplate that the real mechanism of action of some “mycotoxin-binders” might be directly opposite to the one which can be guessed from their name and is so widely accepted. This possibility, however, might be supported by the ability of surfactants to alleviate the manifestations of T-2 toxicosis (Coffin J.L. 1981), and by the higher efficacy of “glucomannan binders” in comparison to, say, the charcoal-based ones in spite of much higher in vitro activity of the latter.