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EFFECTS OF AFLATOXIN B1 AND PREPARATION «VITAKORM-BSR-FORTE» ON NO-SYNTHASE ACTIVITY IN RAT LEUKOCYTES

Published: January 22, 2014
By: Golovchak Kristine
The effects of aflatoxin B1 (AFB1) and herbal preparation «Vitakorm-BSR-Forte» on general activity of NO-synthases (NOS) in leukocytes of peripheral blood of white rats were analysed. It was established that the development of experimental aflatoxicosis, provoked by intraperitoneal administration of AFB1 (15 mkg/kg every day) lasting 14 days, was accompanied by a significant decrease in NOS activity compared to control. Inhibition of NOS activity in blood cells was accompanied by a decrease in nitrite content. The using of preparation «Vitakorm-BSR-Forte» led to normalization of these indices in leukocytes. Our results demonstrate the effectiveness of phytopreparation «Vitakorm-BSR-Forte» in reducing of metabolic abnormalities in animal blood cells caused by aflatoxin B1. Ch. M. Golovchak, H. L. Antonyak halyna_antonyak@yahoo.com; ch_golovchak@inenbiol.com.ua, golovchak.kris@gmail.com
Authors:
Golovchak Kristine
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