Lorraine M. Sordillo

IntroductionThe periparturient period in dairy cows is characterized by substantial metabolic stress, endocrine changes, depressed feed intake, and negative energy balance [1]. In response to these changes, dairy cows mobilize adipose tissue triglyceride (TG), leading to elevated non-esterified fatty acid (NEFA) concentrations in the blood. The high flux of blood NEFA to the liver often exceeds th ...

Escherichia coli bacteria are a major cause of clinical coliform mastitis in dairy cattle. Uncontrolled bacterial replication caused by dysfunctional immune responses results in severe mammary tissue damage and death. Excessive production of reactive metabolites (RM) by phagocytic cells results in oxidative mammary tissue damage observed during coliform mastitis. Increased metabolism of polyunsatu ...

1. IntroductionInflammation contributes to a variety of human and veterinary diseases, including mastitis. Bovine mastitis caused by Streptococcus uberis results in severe damage to milkproducing tissues as a result of an uncontrolled inflammatory response. Previous clinical and histopathological data suggested that disruption of the endothelial barrier contributed to disease pathology. For exampl ...