Adam Fahrenholz

David Wicker Ph. D. I agree with remaining below 10% CV, whether it is an arbitrary value or not, as the historical data and precedence supports it. I am referring more to a scenario of achieving 4% rather than 8% with an additional 20 seconds of mix time and whether those 20 seconds may be leveraged in some cases. As you said, larger animals are likely to tolerate this and I believe some (relativ ...

Ricardo Hume Not specifically tied to validated CV's, but yes, I have run across an instance where a facility has strategically reduced mixing times for certain formulas to create flexibility for increasing time on others. I don't necessarily like it without having the CV values, but if they could be validated and shown not to have a negative impact on animal performance, it could be a feasible da ...

Certainly an interesting discussion, I appreciate everyone's insight. As for the debate around the % CV, I think one of our issues is thinking in absolutes. As Marc mentioned, the "standard" continues to be 10%, which is not to say that facilities shouldn't strive for even better homogeneity as technology improves. However, due to the variable precision of some assays (as Dr. Wicker describes) i ...