We have safe, efficacious and cost effective alternative plant based management of mastitis and few other health conditions in animals.
Dr. M N B Nair & DR. Kumar- FRLHT, Bangalore
Prof. Punnyamurthy- TANUVAS
Hello Dr Sethi, For preventing mastitis in dairy animals give 30gm doses of tri-Sodium citrate quite often as before parturition and during lactation by monitoring pH and citrate content of milk. Mixing of this salt in feed deteriorates because of its hygroscopic nature. Th graded pH papers can be obtained from any shop dealing with chemicals for laboratory use as Glaxo-Smith-kline etc.
With regards Jasmer
Hello Dr Sethi, You are right in considering the feeding of citrate as a preventative for mastitis in dairy animals. In fact we have tried this at certain farms with great success. The important point in this procedure is to monitor the pH and citrate content of milk during lactation. The monitoring of milk pH with graded papers strips, indeed, is the most easy, economical and desirably reliable which could be routinly practiced at any dairy farm.
with regards Jasmer
Hello Dr Sethi and Dr Elena, We have researched extensively the basic cause and radical therapy of clinical/sub-clinical mastitis in bovines. The results of our investigations are published in various journals of repute e.g., Vety Rec , Indian J Dairy Sci, Proc. World Vety Conf. etc., and have been reviewed in various review papers. The basic cause of mastitis is found to be Citrate deficiency and the treatment consists of administration of 30gms of tri-Sodium citrate disssolved in ~250 ml of drinking water given once daily till recovery, which usually takes 3-5 days. However, tri-Sodium citrate can also be administerd I/V as 5% solution in sterilized normal saline in 5oml doses in the morning and evening followed by 30gm doses orally, if necessary, till recovery which is usually 1-3 days. Moreover, this treatment is also very effective against mastitis resistant to routinely used antibiotics etc. The treatment is safe, economical, free from hazards, no discarding of milk as the chemical is normal content in the in TCA cycle. This treatment has been routinely used against mastitis in cows in NewZeland, Trinidad Tobago, Pakistan, India, to cite a few, and many more countries.
with regards KS Dhillon and Dr Jasmer singh
Hello Elena
You are requested to read the article " Pathobilogy, etiology and novel treatment of mastitis in buffaloe' by Dr KS Dhillon and Dr Jasmer singh which appeared in ' Engormix.com" sometime ago.
Jasmer
Hello Mr Cedden,
Mastitis whether sub-clinical or clinical, the cause is invariably same and thus treatment same. The cause of mastitis is citrate deficiency and treatment is to replenish this deficiency by extraneous administeration of tri-Sodium citrate orally or I/V. The oral dose is 30gm in ~250ml of water as a drench once daily till recovery ( which is usually3-5 ays). The I/V dose is 5% solution in sterlized normal saline as 50ml morning and evening. This treatment is effective even in mastitis cases refrectory to antibiotic therapy. The other query regarding infusion in udder with citrate we have not tried.
Dr Jasmer Singh
Re. Recent trends in mastitis management By Dr Sharma covers most commonly presumed causes with good management practices for the control of mastitis in bovines. Here we give the basic cause and radical treatment of this most economical and dreaded ailment of dairy industry perpetually inflicting all over the globe.
Kundan Singh Dhillon and Jasmer Singh (Both retd. Professors from Pb. Agril. Univ., Ludhiana, India).
Citrate has been regarded as the harbinger of lactogenesis and its quantity increases spectaculrly arround parturition (2-3 days) and its concentration in milk is directly proportionate to the volume of milk throughout lactation. The other cardinal function citrate in udder is to sequester Ca2+ and maintain the eqilibrium of Ca++ and H+ to regulate the pH of milk in udder (~6.50). Whenever there is disturbed homeostasis of citrate in udder the moderator effect on Ca sequesteration is upset and the Free Ca++ form clumps and behave like Lime which injures the secretory epithelium resulting in iflammation. The tight junctions present between blood and milk become compromised and leaky culminating in the swapping of ions between milk and blood. The main ions are Na, K, Cl, Hco3, Citrate which freely transfer/exchange making the milk pH equivalent to blood (7.20 or even more) i.e., alkaline. The injury caused by Ca++ and the alkaline milieu in udder provides the most conducible conditions for the invasion by the environmental pathogens and initiate an explosive iinflammatory reaction. Inflammation atracts body defense cells like macrophases, PML and cytokines etc., resulting in varying degrees of pathological entities and clinical signs of infectious Mastitis. Hence, the basic cause of mastitis is the dyshomeostasis of Citrate with subsequent infection by the enviromental pathogens (commensals?) i.e., the infectious causes of mastitis are secondary. Moreover, a significant number(~30%) of mastitis are usually sterile and studies to deliberately infect the udder with extraneous infections have failed to cause mastitis in 100% of cases. We treated clinical cases of mastitis with oral administeration of 30gm of tri-Sodium citrate in 250ml of water which took 3-5 days for full recovery. We also standardised the I/V dose of tri-Sodium citrate as 5% most applicable in the field cases of different grades of mastitis. This treatment was also particularly very effective in cases refrectory to antibiotics and the cure rate was reduced to 1-3 days. The treatment is safe, economical, no milk withrawal or waste of milk no culling or replacements etc., and no hazzards to consumers.
Dr Jasmer singh, Rtd.Prof. PAU, Ludhiana, Punjab.
The most important aspect to prevent/treat a disease is to know its most probable cause and then devise control measures.Our team has worked on mastitis for quite some time and published our findings in scientific journals of repute. In the above comments some people had talked about the use of tri-Sodium citrate as a treatment for mastitis in bovines. we have reported for the first time the cause and succesful treatment of mastitis. The cause is deficiency of citrate in the udder and its replenishment by oral or I/V administration of tri-Sodium citrate is the radical treatment of mastitis.
To explain the case precisely please see our research papers on the internet under " Tri-Sodium citrate as treatment of mastitis in bovines, By- K. S. Dhillon and Jasmer Singh and others.
1. Dhillon KS , Singh J and Gill BS. 1989. A new horizon into the treatment mastitis in..., J Res.m Punjab Agri. Univ.,26: 477
2. Dhillon KS and Singh J. 2009. Veterinary Record, Augst 8 2009, 165: 183.
3. ................, and ............ 2011. Proceedings 30th World Vety. Assoc., Conf. held at Capetown, Oct 10-14, pp 42.
Thanks Dr. Jasmer, I will communicate my experience with T.S.Citrate in the near future.
Yours
P.K.Sethi
Hello Dr. Jasmer Singh kindly inform citrate addition per ton of feed and availability of graded paper strips in India.
Yours
P.K.S.