Poultry, and chicken specifically, have been a research model organism for decades. Much of our most fundamental and consequential discoveries in immunology and disease have come from the study of poultry. These discoveries cross the research spectrum from oncogenes to B-cells. At the same time chickens have been aggressively, and successfully, bred for greater growth and feed efficiency. While this breeding has been an indisputable success in terms of food animal production, it has had consequences in terms of emerging and re-emerging disease challenges in poultry. These challenges have a common theme in the form of the recent research perspective called immunometabolism. Immunometabolism refers to the interconnectedness of immune responses and metabolic processes. We can use an immunometabolic perspective to better understand poultry disease, both infectious and not. Immunometabolism has pointed to potential mechanisms of woody breast, the tolerance of chicken toward Salmonella, and the devastating effects of coccidiosis and necrotic enteritis. The challenges that we face in growing poultry ever more efficiently is coupled with greater restrictions on how poultry production is managed. These challenges of immunometabolism are also an opportunity. An integrated metabolic and immunologic perspective allows us to more fully understand disease pathogenesis and the mechanism of action of effective disease interventions. Importantly, it also opens up an entirely new world of possible solutions, nutritional and metabolic solutions, to the pressing health and disease problems in poultry.
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