MTOX + Mfeed Intervention on Performances of Broiler Layer Breeder

INTRODUCTION 

Fowl cholera is a Bacteria disease caused by a gram-negative spore forming bacterium which can affect a wider range of hosts such as Turkeys, Ducks and chicken.

This disease also known as Avian pasteurelosis can affect all age grade of chicken but older birds are more susceptible with a higher incidence recorded among males.

The disease is closely associated with stress of worm infestation which are more prominent in laying birds at the onset of lay to peak production.

The clinical symptoms of this disease may include among others the under listed signs and pathology:

Ataxia and backward retraction of the head

The unique problem in the management of fowl cholera outbreak is the poor response to which a diseased liver can efficiently metabolize drugs and feed ,more so in the enviroment  contaminated with mycotoxin  and mycotoxin contaminated  materials that are used for feed formulation. This situation is more complicated in fowl cholera infection because of  additional production of endotoxin  by this organism in the host animal

What then should be the role of veterinarians and nutritionist in managing an outbreak of fowl cholera under the above described scenario.

How will the efficiency of immune response to Bacteria vaccination be guaranteed in this environmen

The above statement constitute the multiple challenges facing the Nutritionist and veterinarians in   managing fowl cholera outbreaks  in the humid tropical climate, as in Africa 

The objective of this case study is to examine the efficiency of a synergistic dietary intervention of Mtox++Mfeed (all are new generation Nano- based toxin binder  and Nanobiotic now suitable )in the management of fowl cholera outbreak in a Broiler breeder flock

What is MTox+(AmadeiteR)?

MTox+ is a new generation Nano - based toxin binder, a patented nanotechnology activated Montmorilonite and sea weed extract of Olmix, France,but marketed in Nigeria by Orkila chemicals. 

This ia a natural nano alternative, for enhancement of digestion performance in animal feed,containing Amadeite which gives it the catalytic properties that bind the Gram negative bacteria

The products Mtox+ and Mfeed have a wide spectrum of adsorption that can make them bind in a high capacity, like activated carbon to large molecule toxins such as DON,FUMINOSIN and ZEARALININE ,but without binding the vitamins and minerals while Mfeed binds  the gram negative bacteria eg Ecli Salmonella and pasteurela organisms.

FLOCKS HISTORY

The Breeder farm investigated is a medium scale project located in the south west humid tropic of Nigeria
 and a Broiler breeder of Hubbard flex that were housed in three flocks of 3a,2b and 1b.  All the flocks were raised in the same environment under the same management practice and  feeding regime

FLOCK STATISTICS

Table 1 below showed the flock statistics during 8 weeks of investigation of this study.

TABLE 1: FLOCK STASTISTICS

 

Result of Broiler Breeder performances before and after Mtox + intervention is as shown in the under listed Tables and graphs numbered 3A, 2B and 1B respectively

Flocks 3a+2b were severely challenged by an outbreak of pasteurella Multocida(Fowl cholera) which dropped egg production in both houses to 22.355% and 37.82% respectively at 26 weeks of age mortality score on week 26 for both houses stood st 2.6% and 2.68%  indicative of high

House 1B the youngest but not yet affected was prophylactically exposed to MTOX+ and Mfeed  earlier in the growing stage as shown in the graph 1B

The flocks had  been maintained  on a broad spectrum antibiotic which did not show encouraging result on mortality reduction and production increase , such that the 2 affected flocks 3a and 2b experienced very low production of weekly average of 22.3% for House 3a and 37.83% for house 2b at an age when flocks were suppose to approach a steady peak performance,

Flock 1b that was the youngest flock had  not exhibited the observed signs of fowl cholera and was proactively managed as a control flock on  Mtox++Mfeed intervention in feed at the dosage of 0.5kg/Ton and 1kg/ton respectively to prevent a declining production as exhibited by flocks 3A and 2B

CONTROL₊

Mitox++Mfeed was synergistically combined to replace antibiotic medication in flocks 3A+2B but prophylactically administered to flock 1b to check mate the course and spread of the infection to the flock and avoid the drastic drop in production recorded at age 25-26 weeks for houses 3A & 2B (31+2b) Mtox++Mfeed were strategically applied at 0.5kg/Ton and 1kg/Ton at age 23weeks( see tables)

DURATION OF INVESTIGATION      8 WEEK

In this report MTox++Mfeed intervention as a, dietary approach in the management of fowl cholera is clearly demonstrated with the use of this new generation Nano products of Olmix, France< marketed in Nigeria by Orkila.

This intervention recognized that the liver is a vulnerable site in the pathogenesis of pasteurellosis due to fatty degeneration and posed limitation to efficient metabolisms of the antibiotics for chemotherapy(rational for using Mfeed). as well  as for adequate immune response to Bacteria vaccination because endotixins produced by the organism and exogenous mycotoxin in  contaminated feed have been incriminated as possible aetiology for fatty degeneration in fowl cholera epidemics(Adejoro2004)

In the tropics, we have recorded a higher incidence of fowl cholera during the dry season period with more occurrences in layers fed on high energy diet.(Adejoro 2004)

In this study MToX++Mfeed intervention had shown that over-reliance on antibiotics  chemotherapy  may not give a desirable result in an epidemic of fowl cholera. The dietary intervention of MTox++Mfeed   had proved very successful in the treatment and control of fowl cholera infection in Broiler breeder 

It is my view that the use of bacteria vaccine as sole prophylaxis may need to be replaced or synergized with a dietary inclusion of the new generation Nano products( Toxin binder  in  other to present a better and healthier condition for flocks reared in an environment of high mycotoxin induced fowl cholera.

MTox inclusion in the rage of 0.5kg/ton – 2kg/ton will serve useful results in managing and controlling  such outbreaks

Adejoro S.O  Case study of chemotherapy and dietary adjustment in the management and Treatment of Fowl cholera in South West Nigeria  page64-71 of Hand Book of poultry feed formulation in the tropics ISBN 978-30272-6-2 ( First published2004)

Adejoro  S.O 2011 www.engormix.com DAY OLD CHICKS (DOC) HEALTH STATUS AND EARLY MORTALITIES: CONSEQUENCES OF MYCOTOXIN ON BREEDER FARMS AND HATCHERY MANAGEMENT IN WEST AFRICA: CASE STUDIES FROM NIGERIA (an engormix publication)

Adejoro S O 2011 The possible causes of vaccination failures against Mareks, a contribution to an international panel of discussant www.engormix.com  authored by Grzegorz Wozniakowski(Lublin Poland)

R.Havenaar! and Herve Demais2 2004 Efficacy of sequestrant/chelator Amadeite in binding Mycotoxin during transit through a dynamic gastrointestinal model(TIM) simulating the GI conditions of pigs www.olmix.com