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Infectious bursal disease is seen in young domestic chickens worldwide and is caused by infectious bursal disease virus (IBDV). Clinical signs include listlessness, watery diarrhea, ruffled feathers, and dehydration. Morbidity rate is high and mortality rate is usually low, but some virulent strains cause mortality rates of 60% or higher. Macroscopic and microscopic lesions in the cloacal bursa and molecular identification of the viral genome are used for diagnosis. Vectored and attenuated live virus vaccines can be used to induce active immunity in chicks as the maternal antibodies wane. Infectious bursal disease is an economically important viral disease of young domestic chickens worldwide. Infectious bursal disease was first identified in Gumboro, Delaware, in 1962. Infectious bursal disease affects young domestic chickens worldwide. Classical strains predominated until the emergence of variant IBDV strains in 1986.