New resistance gene found in Salmonella isolated from chickens
Published:June 2, 2017
Summary
A team of Canadian scientists has identified a gene that confers resistance to the broad-spectrum antibiotic fosfomycin, according to a study yesterday in Antimicrobial Agents and Chemotherapy .
The gene, dubbed fosA7, was found in 15 Salmonella enterica isolates from broiler chickens in British Columbia. The isolates were of the Salmonella Heidelberg serotype, wh...
This is an interesting findings on one of the etiology of resistance development to prevailing antibiotic on salmonella enterica in poultry,which further proved the risk of cross resistances through the plasmid transfer of the fosA7 Factor responsible for this resistance development
I wish to complement from various research findings on mycotoxin of a possibility of their molecular interactions with hormones and microorganism to reverse functions and create resistances
Some mycotoxin like Zearalonone could modify the molecular structure of the hormone estrogen, thereby causing reproductive disruption in pig ,Broiler Breeder and Layer Breeder stocks
It was reported earlier by scientists that Zearalinone because of its similar molecular structure, with the female hormone estrogen do compete with the cytoplasmic oestrogen receptor to produce alpha Zearalenone and Beta zearalenone( likened to a mutation efect)responsible for hyper oestrogen responses in Breeder and in sows(Olmix publications)
Similarly the theory that mycotoxin could trigger an increase in CYTOKINS production that could result in the production of non specific antibodies could also potentiate resistances to antibiotic efficacy in therapy
I wish to import the experiences of Dr Bohama from NEPAL on a forum discussion of mycotoxin, reported in engormix discussion on Mareks vaccination failures, that this metabolite was responsible for vacination failures to Mareks in NEPAL, similar to report published in engormix on Nigeria case studies by Dr Stephen Adejoro
In a Panel discussion on mycotoxin initiated by Dr Wosniakowski from Lublium Poland ,on repeated Mareks disease vaccination failure,he concluded in the summary of the panelist discussion that 'The main problem in achieving a successful vaccination is the hygine and early infection to mareks as was pointed out by Dr Adejoro" (engormix panelist discussion on Mareks Vaccination failure www.engormix.com )
While I commend this study by the team of Canadian experts,I wish to plead for a follow up research by other international animal food security experts on the possible genetic implications of mycotoxins on resistances develpment to antibiotics
Livestock Industry Foundation For Africa NGO www.lifango.org is dedicated to encourage related studies to boost animal food security world wide
Ali, this simply means that if that new salmonella Fosfomycin resistant gene fos A7 is transfered to a human through consumption of such infected chicken, that infection maybe resistant to the antibiotic Fosfomycin, and that is the whole extent of food safety, public health and all that is what one health, one medicine is all about.