Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics

Published on: 04/19/2019
Author/s : Kelsy Robinson 1, Xi Ma 2, Yulan Liu 3, Shiyan Qiao 2, Yongqing Hou 3, Guolong Zhang 1, 3. / 1 Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA; 2 State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; 3 Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China.

1. IntroductionIn-feed supplementation of antibiotics was firstly reported to promote growth in chickens (Moore et al., 1946) and subsequently in pigs (Jukes et al., 1950; Luecke et al., 1950). Since then, antibiotics have been routinely used in livestock production at subtherapeutic levels for disease prevention and growth promotion and are more commonly known as antibiotic growth promoters (Dibn...

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April 19, 2019

Dr. Zhang, I congratulate you on the published article. If I am not mistaken, I think that one of the problems of using the medicated diet with high doses of antimicrobials in the production of pork that is adopted in some countries is exactly the effect of these drugs in reducing the production of antimicrobial peptides that are naturally produced by animals due to the decreased activity of the microbiota.

April 20, 2019

I'm very interested in this article due to my 40 years of experience in Thai Livestock production, which tries to avoid using Antibiotics in animal farming. The good management practices and the ABO alternatives are most concerned. I would like to collect more information and learn more to educate and advise our customers.

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Nelson Ruiz
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