Immunosuppression can increase susceptibility to infections and mortalities, increase feed conversion, reduce vaccine effectiveness and increase total production cost

Introduction to Immunity

Immunity refers to the body's ability to resist or defend against infections, diseases, and other unwanted biological invasions. There are two main types of immunity.

Innate immunity is the host's first line of defense against invading pathogens but some pathogens particularly immunosuppressive viruses have evolved sophisticated mechanisms to evade the host's innate immune responses and survive within the host. Adaptive Immunity targets specific pathogens that the body has encountered before. When the immune system fails, it can result in immunosuppression.

Immunosuppression originally defined as “a state of temporary or permanent dysfunction of the immune response resulting from damage to the immune system and leading to increased susceptibility to disease” includes suboptimal responses in antibody production, innate and cellular immunities.

Immunosuppression is a syndrome not a disease, Several environmental factors causing immunosuppression are related to management problems such as inadequate water or food supply, Nutritional deficiencies, Mycotoxins, Vaccinations, ammonia in the houses, excess dust, temperature stress, social interactions within a flock, and Infectious agents such as IBV, IBH, CIAV and Mareks.

Immunosuppression can increase susceptibility to infections and mortalities, increase feed conversion, reduce vaccine effectiveness and increase total production cost. As a result, they have substantial negative impacts on poultry health and welfare, and production performance in the poultry industry. Understanding the pathogenesis of immunosuppressive diseases is crucial to safeguarding health and productivity in the poultry industry.

IMMUNOTECH: The Lucrative solution for Immunosuppression

Immunotech is a mixture of functional enzymes and polyphenols, making it a powerful immunomodulator, anti-inflammatory, and antioxidant. Its unique formula not only enhances immunity but also helps to reduce inflammation and alleviate stress.

IMMUNOTECH targets and disrupts the proteins in virus cell walls, preventing the virus from replicating or attacking vital cells in the body. It revitalizes a compromised immune system, helping restore it to normalcy and supporting the fight against infections. It functions in various ways, including:

As Immunity

The enzymes present in IMMUNOTECH cleave the antigenic surface protein of organisms and digest their outer coat and the released enzyme-surface protein complex is ingested by macrophages and dendritic cells and induces higher antibody production.
It inhibits the pathogen's ability to attach to host cells by reducing the receptors available for pathogens, thereby decreasing infectivity.
When administered as a preventive measure, IMMUNOTECH functions like a “biological vacuum cleaner,” purifying the blood and eliminating viruses from circulation. This significantly reduces the inflammatory response and enables normal immune functions to perform at a much healthier level.
IMMUNOTECH causes the enhancement of immune cells to kill bacteria, viruses, molds and fungi.
The systemic enzymes in IMMUNOTECH break down immune complexes and eliminate them from circulation paving the way for the immune cell's action.
IMMUNOTECH boosts the bacteria-killing power of antibiotics and inhibits biofilm formation.

As Antioxidant

Polyphenols such as rutin are potent antioxidants and effectively neutralize the harmful free radicals generated by any means such as a change in temperature, transportation, etc.

As Anti-inflammatory

At the molecular level, IMMUNOTECH blocks proinflammatory metabolites such as histamine, serotonin, and bradykinin that drive inflammation. Its enzymes modify the arachidonate pathway, reducing thromboxane production without affecting cyclooxygenase. This results in reduced edema and inflammation, and restores balance between the two types of prostaglandins. Additionally, it enhances blood flow volume and fluidity, aiding in the removal of inflammatory by-products.
Enzymes activate a-2 macroglobulin, a cytokine catcher that typically exists in its inactive (slow) form in the blood. This activation leads to a quicker clearance of cytokine TNFa, thereby reducing the stimulus for the expression of adhesion molecules.

Trial Report

A straight run flock of 400 Cobb 400Y broiler chickens were distributed into 2 treatment groups and were raised on litter for 42 days. The birds were vaccinated according to the standard vaccination procedure against Newcastle disease (5- d and 20-d) and IBD (12-d).

The treatment diets were as follows:

1. T1: Control diet devoid of any immune stimulant.
2. T2: Control diet supplemented with Immunotech at the rate of 250 mg/kg feed throughout the experimental period.

Vaccine titre against IBD

Vaccine titre (log10 values) against infectious bursal disease measured at 12-d, 28-d and 40-d of age is given below

Vaccine titre against IBD in the T1 group without any immune stimulant went on decreasing with age. On the contrary, in the T2 group, which was supplemented with Immunotech, vaccine titre decreased up to 28-d of age but increased thereafter at 40-d of age. Numerically, in the T2 group, IBD vaccine titre was comparatively lower when measured on 12-d and 28-d of age but it was significantly better when measured at 40 d of age (P < 0.05). The drop in the IBD titre value from 12-d to 40-d was 42 % while that in the T2 group was only 14%. The above data clearly indicate that supplementation of Immunotech has substantially improved IBD titre in the birds especially after 28-d of age.

The above values indicate clearly that the vaccine titre against ND in the control group increased at 20-d of age in both the groups as compared with the initial values (age effect P < 0.05). However, in the T1 group which was devoid of any immune stimulant the vaccine titre decreased when measured at 40-d of age and came back to its initial level. On the contrary, in the T2 group, which was supplemented with Immunotech, the vaccine titre against ND increased linearly and a difference of 8% hike in the ND titre value was obtained from the initial value in this case.

IMMUNOTECH in a nutshell