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Keywords: Acidifiers, Direct-fed microbials, Minerals, Plant extracts, Prebiotics, Pigs.
Acosta JA, Gable NK, Frank JW, Bass BE, Patience JF. Effect of lactose, inulin, Lacto-bacillus acidophilus fermentation product, or dietary antibiotics on nursery pig digestibility and nitrogen retention. J Anim Sci 2017;95(Suppl. 2):143.
Ahmed ST, Hwang JA, Hoon J, Mun HS, Yang CJ. Comparison of single and blend acidifiers as alternative to antibiotics on growth performance, fecal microflora, and humoral immunity in weaned piglets. Asian Australas J Anim Sci 2014;27: 93e100.
Alam AN, Sarker SA, Wahed MA, Khatun M, Rahaman MM. Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation. Gut 1994;35:1707e11.
Alexopoulos C, Georgoulakis IE, Tzivara A, Kyriakis CS, Govaris A, Kyriakis SC. Field evaluation of the effect of a probiotic-containing Bacillus licheniformis and Bacillus subtilis spores on the health status, performance, and carcass quality of grower and finisher pigs. J Vet Med A Physiol Pathol Clin Med 2004;51:306e12.
Allan P, Bilkei G. Oregano improves reproductive performance of sows. Ther-iogenology 2005;63:716e21.
Al-Sadi R, Boivin M, Ma T. Mechanism of cytokine modulation of epithelial tight junction barrier. Front Biosci 2009;14:2765e78.
Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect 1999;1:125e9.
Apgar GA, Kornegay ET, Lindemann MD, Wood CM. The effect of feeding various levels of Bifidobacterium globosum A on the performance, gastrointestinal measurements, and immunity of weanling pigs and on the performance and carcass measurements of growing-finishing pigs. J Anim Sci 1993;71:2173e9.
Ariza-Nieto C, Bandrick M, Baidoo SK, Anil L, Molitor TW, Hathaway MR. Effect of dietary supplementation of oregano essential oils to sows on colostrum and milk composition, growth pattern and immune status of suckling pigs. J Anim Sci 2011;89:1079e89.
Armstrong TA, Cook DR, Ward MM, Williams CM, Spears JW. Effect of dietary copper source (cupric citrate and cupric sulfate) and concentration on growth perfor-mance and fecal copper excretion in weanling pigs. J Anim Sci 2004;82: 1234e40.
Awati A, Williams BA, Bosch MW, Gerrits WJ, Verstegen MW. Effect of inclusion of fermentable carbohydrates in the diet on fermentation end-product profile in feces of weanling piglets. J Anim Sci 2006;84:2133e40.
Bach Knudsen KE, Hedemann MS, Lærke HN. The role of carbohydrates in intestinal health of pigs. Anim Feed Sci Technol 2012;173:41e53.
Bailey M. Interaction between immunological system, microflora of the gastrointes-tinal tract and metabolism. In: Skomial J, Lapierre H, editors. Energy and protein metabolism and nutrition. 5th EAAP international symposium on energy and protein metabolism and nutrition, Krakow, Poland, 12-15 September 2016. Wageningen, The Netherlands: Wageningen Academic Publishers; 2016. p. 27e33.
Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oilsea review. Food Chem Toxicol 2008;46:446e75.
Banks KM, Thompson KL, Rush JK, Applegate TJ. Effects of copper source on phos-phorus retention in broiler chicks and laying hens. Poult Sci 2004;83:990e6.
Baxter JH, Van Wyk JJ, Follis Jr RH. A bone disorder associated with copper defi-ciency. II. Histological and chemical studies on the bones. Bull Johns Hopkins Hosp 1953;93:25e39.
Baydar NG, Ozkan G, Sagdiç O. Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts. Food Control 2004;15:335e9.
Bertolo R, Bettger W, Atkinson S. Calcium competes with zinc for a channel mechanism on the brush border membrane of piglet intestine. J Nutr Biochem 2001;12:66e72.
Blank R, Mosenthin R, Sauer WC, Huang S. Effect of fumaric acid and dietary buffering capacity on ileal and fecal amino acid digestibilities in early-weaned pigs. J Anim Sci 1999;77:2974e84.
Blavi L, Sola-Oriol D, Perez JF, Stein HH. Effects of zinc oxide and microbial phytase on digestibility of calcium and phosphorus in maize-based diets fed to growing pigs. J Anim Sci 2017;95:847e54.
Bontempo V, Di Giancamillo A, Savoini G, Dell’Orto V, Domeneghini C. Live yeast dietary supplementation acts upon intestinal morpho-functional aspects and growth in weanling piglets. Anim Feed Sci Technol 2006;129:224e36. https:// doi.org/10.1016/j.anifeedsci.2005.12.015.
Bosi P, Sarli G, Casini L, De Filippi S, Trevisi P, Mazzoni M, et al. The influence of fat protection of calcium formate on growth and intestinal defence in Escher-ichia coli K88-challenged weanling pigs. Anim Feed Sci Technol 2007;139: 170e85.
Broek LAM, Hinz SWA, Beldman G, Vincken JP, Voragen AGJ. Bifidobacterium car-bohydrases e their role in breakdown and synthesis of (potential) prebiotics. Mol Nutr Food Res 2008;52:146e63.
Bühler K, Liesegang A, Bucher B, Wenk C, Broz J. Influence of benzoic acid and phytase in low-phosphorus diets on bone characteristics in growing-finishing pigs. J Anim Sci 2010;88:3363e71.
Burt S. Essential oils: their antibacterial properties and potential applications in foodsea review. Int J Food Microbiol 2004;94:223e53.
Burt SA, van der Zee R, Koets AP, de Graaff AM, van Knapen F, Gaastra W, et al. Carvacrol induces heat shock protein 60 and inhibits synthesis of flagellin in Escherichia coli O157:H7. Appl Environ Microbiol 2007;73:4484e90.
Calsamiglia S, Busquet M, Cardozo PW, Castillejos L, Ferret A. Invited review: essential oils as modifiers of rumen microbial fermentation. J Dairy Sci 2007;90: 2580e95.
Carlson M, Veum T, Turk J. Effects of yeast extract versus animal plasma in weanling pig diets on growth performance and intestinal morphology. J Swine Health Prod 2005;13:204.
Carlson MS, Hoover SL, Hill GM, Link JE, Turk JR. Effect of pharmacological zinc on intestinal metallothionein concentration and morphology in the nursery pig. J Anim Sci 1998;76(Suppl. 1):57 [Abstr].
Carson CF, Mee BJ, Riley TV. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Antimicrob Agents Chemother 2002;46:1914e20.
Carver JD, Walker AW. The role of nucleotides in human nutrition. J Nutr Biochem 1995;6:58e72.
Carver JD. Dietary nucleotides: cellular immune, intestinal and hepatic system ef-fects. J Nutr 1994;124(Suppl. 1):144se8s.
Case CL, Carlson MS. Effect of feeding organic and inorganic sources of additional zinc on growth performance and zinc balance in nursery pigs. J Anim Sci 2002;80(7):1917e24.
Cho JH, Zhao PY, Kim IH. Probiotics as a dietary additive for pigs: a review. J Anim Vet Adv 2011;10:2127e34.
Choi CY, Park KR, Lee JH, Jeon YJ, Liu KH, Oh S, et al. Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase. Eur J Pharmacol 2007;576:151e9.
Cosgrove M. Perinatal and infant nutrition. Nucleotides. Nutrition 1998;14:748e51. Cromwell GL, Lindemann MD, Monegue HJ, Hall DD, Orr Jr DE. Tribasic copper chloride and copper sulfate as copper sources for weanling pigs. J Anim Sci 1998;76:118e23.
Cromwell GL. Feed additives in swine diets. In: Chiba LI, editor. Sustainable swine nutrition. 1st ed. Ames, IA: John Wiley & Sons, Inc; 2013. p. 302e4.
Cullen SP, Monahan FJ, Callan JJ, O'Doherty JV. The effect of dietary garlic and rosemary on grower-finisher pig performance and sensory characteristics of pork. Ir J Agric Food Res 2005;44:57e67.
Davis ME, Parrott T, Brown DC, de Rodas BZ, Johnson ZB, Maxwell CV, et al. Effect of a Bacillus-based direct-fed microbial feed supplement on growth performance and pen cleaning characteristics of growing-finishing pigs. J Anim Sci 2008;86: 1459e67.
Dawson KA, Newman KE, Boling JA. Effects of microbial supplements containing yeast and lactobacilli on roughage-fed ruminal microbial activities. J Anim Sci 1990;68:3392e8.
de Lange CFM, Pluske J, Gong J, Nyachoti CM. Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs. Livest Sci 2010;134:124e34.
Di Giancamillo A, Domeneghini C, Paratte R, Dell'Orto V, Bontempo V. 2003. Oral feeding with L-Glutamine and Nucleotides: impact on some GALT (gut associ-ated lymphoid tissue) parameters and cell proliferation/death rates in weaning piglets. Ital J Anim Sci 2003;2:364e6.
Diao H, Gao Z, Yu B, Zheng P, He J, Yu J, et al. Effects of benzoic acid (VevoVitall(R)) on the performance and jejunal digestive physiology in young pigs. J Anim Sci Biotechnol 2016;7:32e8.
Djeridane A, Yousfi M, Nadjemi B, Boutassouna D, Stocker P, Vidal N. Antioxidant activity of some algerian medicinal plants extracts containing phenolic com-pounds. Food Chem 2006;97:654e60.
Domeneghini C, Di Giancamillo A, Savoini G, Paratte R, Bontempo V, Dell'Orto V. Structural patterns of swine ileal mucosa following L-glutamine and nucleotide administration during the weaning period. An histochemical and histometrical study. Histol Histopathol 2004;19:49e58.
Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308e16.
Dundar E, Olgun EG, Isiksoy S, Kurkcuoglu M, Baser KH, Bal C. The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat. Exp Toxicol Pathol 2008;59:399e408.
Dunshea FR, Suster D, Kerton DJ, Leury BJ. A capsacin analogue improves growth and dressing rate in pigs, particularly gilts. In: Paterson JE, editor. Manipulating pig production, vol. IX. Werribee, Australia: Australasian Pig Science Association Inc.; 2003. p. 26.
Eckel B, Kirchgessner M, Roth FX. Influence of formic acid on daily weight gain, feed intake, feed conversion rate and digestibility. 1. The nutritive value of organic acids in the rearing of piglets. J Anim Physiol Anim Nutr 1992;62:93e100.
Economou KD, Oreopoulou V, Thomopoulos CD. Antioxidant activity of some plant extracts of the family labiatae. J Am Oil Chem Soc 1991;68:109e13.
Eidelsburger U, Roth RX, Kirchgessner M. Influence of formic acid, calcium formate and sodium bicarbonate on daily weight gain, feed intake, feed conversion rate and digestibility. 7. Nutritive value of organic acids in piglet rearing. J Anim Physiol Anim Nutr 1992a;67:258e67.
Eidelsburger U, Roth RX, Kirchgessner M. Influence of fumaric acid, hydrochloric acid, sodium formate, tylosin and toyocerin on daily weight gain, feed con-version rate and digestibility. 11. Nutritive value of organic acids in piglet rearing. J Anim Physiol Anim Nutr 1992b;68:82e92.
El Asbahani H, Miladi K, Badri W, Sala M, Aït Addi EH, Casabianca H, et al. Essential oils: from extraction to encapsulation. Int J Pharm 2015;483:220e43.
Fang CL, Sun H, Wu J, Niu HH, Feng J. Effects of sodium butyrate on growth per-formance, haematological and immunological characteristics of weanling pig-lets. J Anim Physiol Anim Nutr (Berl) 2014;98:680e5.
FAO/WHO (Food and Agriculture Organization/World Health Organization). Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Report of a joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. 2001. p. 1e33. Cordoba, Argentina.
Farag RS, Daw ZY, Hewedi FM, El-Baroty GSA. Antimicrobial activity of some Egyptian spice essential oils. J Food Prot 1989;52:665e7.
Ferrari E, Jarnagin A, Schmidt B. Commercial production of extracellular enzymes. In: Sonenshein A, Hoch J, Losick R, editors. Bacillus subtilis and other gram-positive bacteria. Washington, DC: ASM Press; 1993. p. 917e37.
Frankic T, Levart A, Salobir J. The effect of vitamin E and plant extract mixture composed of carvacrol, cinnamaldehyde and capsaicin on oxidative stress induced by high PUFA load in young pigs. Animal 2010;4:572e8.
Gabert VM, Sauer WC, Schmitz M, Ahrens F, Mosenthin R. The effect of formic acid and buffering capacity on the ileal digestibilities of amino acids and bacterial populations and metabolites in the small intestine of weanling pigs fed semi-purified fish meal diets. Can J Anim Sci 1995;75:615e23.
Gabert VM, Sauer WC. The effect of fumaric acid and sodium fumarate supplemen-tation to diets for weanling pigs on amino acid digestibility and volatile fatty acid concentrations in ileal digesta. Anim Feed Sci Technol 1995;53:243e54.
Galdeano CM, Perdigon G. The probiotic bacterium Lactobacillus casei induces activation of the gut mucosal immune system through innate immunity. Clin Vaccine Immunol 2006;13:219e26.
Gebru E, Lee JS, Son JC, Yang SY, Shin SA, Kim B, et al. Effect of probiotic-, bacte-riophage-, or organic acid-supplemented feeds or fermented soybean meal on the growth performance, acute-phase response, and bacterial shedding of grower pigs challenged with Salmonella enterica serotype Typhimurium. J Anim Sci 2010;88:3880e6.
Gedek B, Roth RF, Kirchgessner M, Wiehler S, Bott A, Eidelsburger U. Influence of fumaric acid, hydrochloric acid, sodium formate, tylosin, and toyocerin on the microflora in different segments of the gastrointestinal tract. 14. Nutritive value of organic acids in piglet rearing. J Anim Physiol Anim Nutr 1992;68:209e17.
Gehlert DR. Role of hypothalamic neuropeptide Y in feeding and obesity. Neuro-peptides 1999;33:329e38.
Giang HH, Viet TQ, Ogle B, Lindberg JE. Effects of supplementation of probiotics on the performance, nutrient digestibility and faecal microflora in growing-finishing pigs. Asian Australas J Anim Sci 2011;24:655e61.
Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995;125:1401e12.
Giesting DW, Easter RA. Response of starter pigs to supplementation of corn-soybean meal diets with organic acids. J Anim Sci 1985;60:1288e94.
Godbee R. Effect of yeast culture on apparent digestibility and nitrogen balance in horses. Clemson, SC: Res. Bull. Clemson Univ.; 1983.
Grela ER, Krusinski R, Matras J. Efficacy of diets with antibiotic and herb mixture additives in feeding of growing-finishing pigs. J Anim Feed Sci 1998;7(Suppl. 1): 171e5.
Grilli E, Messina MR, Tedeschi M, Piva A. Feeding a microencapsulated blend of organic acids and nature identical compounds to weaning pigs improved growth performance and intestinal metabolism. Livest Sci 2010;133:173e5.
Grimble GK, Westwood OM. Nucleotides as immunomodulators in clinical nutri-tion. Curr Opin Clin Nutr Metab Care 2001;4:57e64.
Guerra-Ordaz AA, Gonzalez-Ortiz G, La Ragione RM, Woodward MJ, Collins JW, Perez JF, et al. Lactulose and Lactobacillus plantarum, a potential complemen-tary synbiotic to control postweaning colibacillosis in piglets. Appl Environ Microbiol 2014;80:4879e86.
Guggenbuhl P, Seon A, Quintana AP, Nunes CS. Effects of dietary supplementation with benzoic acid (VevoVitall®) on the zootechnical performance, the gastro-intestinal microflora and the ileal digestibility of the young pig. Livest Sci 2007;108:218e21.
Gülçin I, Güngor S¸ at I, Beydemir S¸ , Elmastas¸ M, Irfan Küfrevio lu O. Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.). Food Chem 2004;87:393e400.
Hahn JD, Baker DH. Growth and plasma zinc responses of young pigs fed phar-macologic levels of zinc. J Anim Sci 1993;71:3020e4.
Halas D, Hansen CF, Hampson DJ, Mullan BP, Kim JC, Wilson RH, et al. Dietary supplementation with benzoic acid improves apparent ileal digestibility of total nitrogen and increases villous height and caecal microbial diversity in weaner pigs. Anim Feed Sci Technol 2010;160:137e47.
Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985e90.
Hanczakowska E, Niwinska B, Grela ER, We?glarzy K, Okon K. Effect of dietary glutamine, glucose and/or sodium butyrate on piglet growth, intestinal envi-ronment, subsequent fattener performance, and meat quality. Czech J Anim Sci 2014;59:460e70.
Hart EB, Steenbock H, Waddell J, Elvehjem CA. Iron in nutrition. VII. Copper as a supplement to iron for hemoglobin building in the rat. 1928. J Biol Chem 2002;277:e22.
Hill GM, Cromwell GL, Crenshaw TD, Dove CR, Ewan RC, Knabe DA, et al. Growth promotion effects and plasma changes from feeding high dietary concentra-tions of zinc and copper to weanling pigs (regional study). J Anim Sci 2000;78: 1010e6.
Hill GM. Minerals and mineral utilization in swine. In: Chiba LI, editor. Sustainable swine nutrition. Oxford, U.K.: Blackwell Publishing Ltd.; 2013. p. 186e9.
Hirano T, Murakami M, Fukada T, Nishida K, Yamasaki S, Suzuki T. Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule. Adv Immunol 2008;97:149e76.
Hojberg O, Canibe N, Poulsen HD, Hedemann MS, Jensen BB. Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets. Appl Environ Microbiol 2005;71:2267e77.
Hu C, Song J, You Z, Luan Z, Li W. Zinc Oxide-Montmorillonite hybrid influences diarrhea, intestinal mucosal integrity, and digestive enzyme activity in weaned pigs. Biol Trace Elem Res 2012;149:190e6.
Hu C, Song J, Li Y, Luan Z, Zhu K. Diosmetite-zinc oxide composite improves in-testinal barrier function, modulates expression of pro-inflammatory cytokines and tight junction protein in early weaned pigs. Br J Nutr 2013a;110:681e8.
Hu CH, Xiao K, Luan ZS, Song J. Early weaning increases intestinal permeability, alters expression of cytokines and tight junction proteins, and activates mitogen-activated protein kinases in pigs. J Anim Sci 2013b;91:1094e101.
Huang C, Song P, Fan P, Hou C, Thacker P, Ma X. Dietary sodium butyrate decreases postweaning diarrhea by modulating intestinal permeability and changing the bacterial communities in weaned piglets. J Nutr 2015;145:2774e80.
Hung IF. The effect of dietary nucleotides in sow and nursery piglet diets on reproduction, growth, and immune response [PhD Thesis]. Lexington: Univer-sity of Kentucky; 2015.
Janz JA, Morel PC, Wilkinson BH, Purchas RW. Preliminary investigation of the ef-fects of low-level dietary inclusion of fragrant essential oils and oleoresins on pig performance and pork quality. Meat Sci 2007;75:350e5.
Jaworski NW, Owusu-Asiedu A, Walsh MC, McCann JC, Loor JJ, Stein HH. Effects of a 3 strain Bacillus-based direct-fed microbial and dietary fiber concentration on growth performance, intestinal concentrations of volatile fatty acids, and expression of genes related to absorption and metabolism of volatile fatty acids in weanling pigs. J Anim Sci 2017;95:308e19.
Jaworski NW, Owusu-Asiedu A, Awati AA, Stein HH. Effect of Bacillus spp. direct-fed microbials on fecal VFA concentrations, growth performance, and carcass characteristics of growing-finishing pigs. J Anim Sci 2014;92(Suppl. 2):56 [Abstract].
Jiang Z, Wei S, Wang Z, Zhu C, Hu S, Zheng C, et al. Effects of different forms of yeast Saccharomyces cerevisiae on growth performance, intestinal development, and systemic immunity in early-weaned piglets. J Anim Sci Biotechnol 2015;6: 47e54.
Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, et al. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol 1999;163:3474e83.
Katouli M, Melin L, Jensen-Waern M, Wallgren P, Mollby R. The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. J Appl Microbiol 1999;87:564e73.
Kenny M, Smidt H, Mengheri E, Miller B. Probiotics - do they have a role in the pig industry? Animal 2011;5:462e70.
Kerrola K. Literature review: isolation of essential oils and flavor compounds by dense carbon dioxide. Food Rev Int 1995;11:547e73.
Kiarie E, Bhandari S, Scott M, Krause DO, Nyachoti CM. Growth performance and gastrointestinal microbial ecology responses of piglets receiving Saccharomyces cerevisiae fermentation products after an oral challenge with Escherichia coli (K88). J Anim Sci 2011;89:1062e78.
Kiarie E, Scott M, Krause DO, Khazanehei H, Khafipour E, Nyachoti CM. Interactions of Saccharomyces cerevisiae fermentation product and an in-feed antibiotic on gastrointestinal and immunological responses in piglets challenged with with Escherichia coli K88. J Anim Sci 2012;90(Suppl. 4):1e3.
Kil DY, Piao LG, Long HF, Lim JS, Yun MS, Kong CS, et al. Effects of organic or inorganic acid supplementation on growth performance, nutrient digestibility and white blood cell counts in weanling pigs. Asian Australas J Anim Sci 2006;19:252e61.
Kil DY, Kwon WB, Kim BG. Dietary acidifiers in weanling pig diets: a review. Rev Colombiana Ciencias Pecuarias 2011;24:231e47.
Kil DY, Stein HH. Invited Review. Management and feeding strategies to ameliorate the impact of removing antibiotic growth promoters from diets fed to weanling pigs. Can J Anim Sci 2010;90:447e60.
Kim J, Hosseindoust A, Lee S, Choi Y, Kim M, Lee J, et al. Bacteriophage cocktail and multi-strain probiotics in the feed for weanling pigs: effects on intestine morphology and targeted intestinal coliforms and clostridium. Animal 2017;11: 45e53. https://doi.org/10.1017/S1751731116001166.
Kishibuchi M, Tsujinaka T, Yano M, Morimoto T, Iijima S, Ogawa A, et al. Effects of nucleosides and a nucleotide mixture on gut mucosal barrier function on parenteral nutrition in rats. JPEN J Parenter Enter Nutr 1997;21:104e11.
Kluge H, Broz J, Eder K. Effects of dietary benzoic acid on urinary pH and nutrient digestibility in lactating sows. Livest Sci 2010;134:119e21.
Kogan G, Kocher A. Role of yeast cell wall polysaccharides in pig nutrition and health protection. Livest Sci 2007;109:161e5.
Kornegay ET, Rhein-Welker D, Lindemann MD, Wood CM. Performance and nutrient digestibility in weanling pigs as influenced by yeast culture additions to starter diets containing dried whey or one of two fiber sources. J Anim Sci 1995;73:1381e9.
Kornegay ET, Risley CR. Nutrient digestibilities of a corn-soybean meal diet as influenced by Bacillus products fed to finishing swine. J Anim Sci 1996;74: 799e805.
Ku PK, Ullrey DE, Miller ER. In: Mills CF, editor. Zinc deficiency and tissue nucleic acid and protein concentration. Edinburgh, UK: E. & S. Livingstone; 1970. p. 158e64.
Kuang Y, Wang Y, Zhang Y, Song Y, Zhang X, Lin Y, et al. Effects of dietary combi-nations of organic acids and medium chain fatty acids as a replacement of zinc oxide on growth, digestibility and immunity of weaned pigs. Anim Feed Sc Technol 2015;208:145e57.
Kulkarni AD, Rudolph FB, Van Buren CT. The role of dietary sources of nucleotides in immune function: a review. J Nutr 1994;124(Suppl. 8):1442se6s.
Lambert RJ, Skandamis PN, Coote PJ, Nychas GJ. A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carva-crol. J Appl Microbiol 2001;91:453e62.
Lang A, Lahav M, Sakhnini E, Barshack I, Fidder HH, Avidan B, et al. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr 2004;23:1199e208.
Lawrence BM, Reynolds RJ. Progress in essential oils. Perfum Flavor 1984;9:23e31. Le Gall M, Gallois M, Seve B, Louveau I, Holst JJ, Oswald IP, et al. Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets. Br J Nutr 2009;102: 1285e96.
Lee DN, Liu SR, Chen YT, Wang RC, Lin SY, Weng CF. Effects of diets supplemented with organic acids and nucleotides on growth, immune responses and digestive tract development in weaned pigs. J Anim Physiol Anim Nutr (Berl) 2007;91: 508e18.
Lee KW, Everts H, Beynen AC. Essential oils in broiler nutrition. Int J Poult Sci 2004;3:738e52. https://doi.org/10.3923/ijps.2004.738.752.
Lee SH, Ingale SL, Kim JS, Kim KH, Lokhande A, Kim EK, et al. Effects of dietary supplementation with Bacillus subtilis LS 1e2 fermentation biomass on growth performance, nutrient digestibility, cecal microbiota and intestinal morphology of weanling pig. Anim Feed Sci Technol 2014;188:102e10.
Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, et al. Inhibitory effect of 2'-hydrox-ycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem Pharmacol 2005;69:791e9.
Lewis MC, Patel DV, Fowler J, Duncker S, Zuercher AW, Mercenier A, et al. Dietary supplementation with Bifidobacterium lactis NCC2818 from weaning reduces local immunoglobulin production in lymphoid-associated tissues but increases systemic antibodies in healthy neonates. Br J Nutr 2013;110:1243e52.
Li BT, van Kessel AG, Caine WR, Huang SX, Kirkwood RN. Small intestinal morphology and bacterial populations in ileal digesta and feces of newly weaned pigs receiving a high dietary level of zinc oxide. Can J Anim Sci 2001;81:511e6.
Li J, Yan L, Zheng X, Liu G, Zhang N, Wang Z. Effect of high dietary copper on weight gain and neuropeptide Y level in the hypothalamus of pigs. J Trace Elem Med Biol 2008a;22:33e8.
Li M, Gong J, Cottrill M, Yu H, de Lange C, Burton J, et al. Evaluation of QIAamp DNA Stool Mini Kit for ecological studies of gut microbiota. J Microbiol Methods 2003;54:13e20.
Li X, Yin J, Li D, Chen X, Zang J, Zhou X. Dietary supplementation with zinc oxide increases Igf-I and Igf-I receptor gene expression in the small intestine of weanling piglets. J Nutr 2006;136:1786e91.
Li Z, Yi G, Yin J, Sun P, Li D, Knight C. Effects of organic acids on growth performance, gastrointestinal pH, intestinal microbial populations and immune responses of weaned pigs. Asian Australas J Anim Sci 2008b;21:252e61.
Li YS, Trenhaile MD, Lima MM, Moore KC, van Sambeek DM, Burkey E, et al. Growth performance and serum IgA concentrations in weanling pigs fed dietary pre-biotics. J Anim Sci 2016;94(Suppl. 2):7 [Abstract].
Lindberg JE. Fiber effects in nutrition and gut health in pigs. J Anim Sci Biotechnol 2014;5:15e21.
Liu P, Piao XS, Kim SW, Wang L, Shen YB, Lee HS, et al. Effects of chito-oligosaccharide supplementation on the growth performance, nutrient di-gestibility, intestinal morphology, and fecal shedding of Escherichia coli and Lactobacillus in weaning pigs. J Anim Sci 2008;86:2609e18.
Liu ST, Hou WX, Cheng SY, Shi BM, Shan AS. Effects of dietary citric acid on per-formance, digestibility of calcium and phosphorus, milk composition and immunoglobulin in sows during late gestation and lactation. Anim Feed Sci Technol 2014a;191:67e75.
Liu Y, Che TM, Song M, Lee JJ, Almeida JA, Bravo D, et al. Dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. J Anim Sci 2013a;91:5668e79.
Liu Y, Song M, Che TM, Almeida JA, Lee JJ, Bravo D, et al. Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli. J Anim Sci 2013b;91:5294e306.
Liu Y, Song M, Che TM, Bravo D, Pettigrew JE. Anti-inflammatory effects of several plant extracts on porcine alveolar macrophages in vitro. J Anim Sci 2012;90:2774e83.
Liu Y, Song M, Che TM, Lee JJ, Bravo D, Maddox CW, et al. Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection. J Anim Sci 2014b;92:2050e62.
Long SF, Xu YT, Pan L, Wang QQ, Wang CL, Wu JY, et al. Mixed organic acids as antibiotic substitutes improve performance, serum immunity, intestinal morphology and microbiota for weaned piglets. Anim Feed Sci Technol 2018;235:23e32.
Lu H, Su S, Ajuwon KM. Butyrate supplementation to gestating sows and piglets induces muscle and adipose tissue oxidative genes and improves growth per-formance. J Anim Sci 2012;90(Suppl. 4):430e2.
Lu R, Wang X, Sun DF, Tian XQ, Zhao SL, Chen YX, et al. Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer. Epige-netics 2008;3:330e5.
Luise D, Motta V, Salvarani C, Chiappelli M, Fusco L, Bertocchi M, et al. Long-term administration of formic acid to weaners: influence on intestinal microbiota, immunity parameters and growth performance. Anim Feed Sci Technol 2017;232:160e8.
Ma YL, Zanton GI, Zhao J, Wedekind K, Escobar J, Vazquez-Anon M. Multitrial analysis of the effects of copper level and source on performance in nursery pigs. J Anim Sci 2015;93:606e14.
Machinsky TG, Kessler M, Ribeiro AML, Moraes L, Mello da Silva IC, Mayorga Cortes ME. Nutrient digestibility and Ca and P balance in pigs receiving butyric acid, phytase and different calcium levels. Ciencia Rural 2015;40:2350e5.
Mahan DC, Newton EA, Cera KR. Effect of supplemental sodium chloride, sodium phosphate, or hydrochloric acid in starter pig diets containing dried whey. J Anim Sci 1996;74:1217e22.
Mallo JJ, Balfagon A, Gracia MI, Honrubia P, Puyalto M. Evaluation of different protections of butyric acid aiming for release in the last part of the gastroin-testinal tract of piglets. J Anim Sci 2012;90(Suppl. 4):227e9.
Manzanilla EG, Perez JF, Martin M, Kramel C, Baucells F, Gasa J. Effect of plant ex-tracts and formic acid on the intestinal equilibrium of early-weaned pigs. J Anim Sci 2004;82:3210e8.
Maribo H. Weaning pigs without antibiotic growth promoters: strategies to improve health and performance. In: Lyons TP, Jacques KA, editors. Nutritional biotech-nology in the feed and food industries. Proc. of Alltech's 19th international sym-posium. Nottingham, UK: Nottingham University Press; 2003. p. 179e84.
Martinez-Puig D, Manzanilla EG, Morales J, Borda E, Perez JF, Pineiro~ C, et al. Dietary nucleotide supplementation reduces occurrence of diarrhoea in early weaned pigs. Livest Sci 2007;108:276e9.
Mateo CD, Dave R, Stein HH. Effects of supplemental nucleosides for newly weaned pigs. J Anim Sci 2004;82(Suppl. 2):42.
Mavromichalis I, Webel DM, Parr EN, Baker DH. Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs. Can J Anim Sci 2001;81:387e91.
McDowell LR. Minerals in animal and human nutrition. San Diego, CA: Academic Press Inc.; 1992.
Meng QW, Yan L, Ao X, Zhou TX, Wang JP, Lee JH, et al. Influence of probiotics in different energy and nutrient density diets on growth performance, nutrient digestibility, meat quality, and blood characteristics in growing-finishing pigs. J Anim Sci 2010;88:3320e6.
Merchant HA, McConnell EL, Liu F, Ramaswamy C, Kulkarni RP, Basit AW, et al. Assessment of gastrointestinal pH, fluid and lymphoid tissue in the Guinea pig, rabbit and pig, and implications for their use in drug development. Eur J Pharm Sci 2011;42:3e10.
Merrifield CA, Lewis MC, Claus SP, Pearce JT, Cloarec O, Duncker S, et al. Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818. Gut 2013;62:842e51.
Michiels J, Missotten J, Van Hoorick A, Ovyn A, Fremaut D, De Smet S, et al. Effects of dose and formulation of carvacrol and thymol on bacteria and some functional traits of the gut in piglets after weaning. Arch Anim Nutr 2010;64:136e54.
Molist F, van Eerden E, Parmentier HK, Vuorenmaa J. Effects of inclusion of hy-drolyzed yeast on the immune response and performance of piglets after weaning. Anim Feed Sci Technol 2014;195:136e41.
Moore KL, Mullan BP, Pluske JR, Kim JC, D'Souza DN. The use of nucleotides, vita-mins and functional amino acids to enhance the structure of the small intestine and circulating measures of immune function in the post-weaned piglet. Anim Feed Sci Technol 2011;165:184e90.
Namkung H, Gong J, Yu H, de Lange CFM. Effect of pharmacological intakes of zinc and copper on growth performance, circulating cytokines and gut microbiota of newly weaned piglets challenged with coliform lipopolysaccharides. Can J Anim Sci 2006;86:511e22. https://doi.org/10.4141/A05-075.
Naqid IA, Owen JP, Maddison BC, Gardner DS, Foster N, Tchorzewska MA, et al. Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs. Anim Feed Sci Technol 2015;201: 57e65.
Neill CR, Nelssen JL, Tokach MD, Goodband RD, DeRouchey JM, Dritz SS, et al. Effects of oregano oil on growth performance of nursery pigs. J Swine Health Prod 2006;14:312e6.
Niers LE, Timmerman HM, Rijkers GT, van Bleek GM, van Uden NO, Knol EF, et al. Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokines. Clin Exp Allergy 2005;35:1481e9.
Nofrarias M, Manzanilla EG, Pujols J, Gibert X, Majo N, Segales J, et al. Effects of spray-dried porcine plasma and plant extracts on intestinal morphology and on leukocyte cell subsets of weaned pigs. J Anim Sci 2006;84:2735e42.
Nousiainen J, Setala J. Lactic acid bacteria as animal probiotics. In: Salminen S, von Wright A, editors. Lactic acid bacteria. New York, NY: Marcel Dekker; 1993. p. 315e56.
NRC. In: Nutrient requirements of swine. 11th rev. Washington, DC: Natl. Acad. Press; 2012.
Oboh G, Puntel RL, Rocha JBT. Hot pepper (Capsicum annuum, Tepin and Capsicum Chinese, Habanero) prevent Fe2þ -induced lipid peroxidation in brain e in vitro. Food Chem 2007;102:178e85.
Owusu-Asiedu A, Jaworski NW, Awati AA, Stein HH. Effect of Bacillus spp. direct-fed microbial supplementation on the nutrient digestibility by weanling pigs. J Anim Sci 2014;92(Suppl. 2):143 [Abstract].
Pang Y, Applegate TJ. Effects of copper source and concentration on in vitro phytate phosphorus hydrolysis by phytase. J Agr Food Chem. 2006;54:1792e6.
Papatsiros VG, Billinis C. The prophylactic use of acidifiers as antibacterial agents in swine. In: Antimicrobial agents, Bobbarala V, editors. InTech, Rijeka, Croatia; 2012. p. 295e310.
Papatsiros VG, Tassis PD, Tzika ED, Papaioannou DS, Petridou E, Alexopoulos C, et al. Effect of benzoic acid and combination of benzoic acid with a probiotic containing Bacillus cereus var. Toyoi in weaned pig nutrition. Pol J Vet Sci 2011;14:117e25.
Partanen KH, Mroz Z. Organic acids for performance enhancement in pig diets. Nutr Res Rev 1999;12:117e45.
Pearce SC, Sanz Fernandez MV, Torrison J, Wilson ME, Baumgard LH, Gabler NK. Dietary organic zinc attenuates heat stress-induced changes in pig intestinal integrity and metabolism. J Anim Sci 2015;93:4702e13.
Perez VG, Waguespack AM, Bidner TD, Southern LL, Fakler TM, Ward TL, et al. Additivity of effects from dietary copper and zinc on growth performance and fecal microbiota of pigs after weaning. J Anim Sci 2011;89:414e25.
Pettigrew JE. Reduced use of antibiotic growth promoters in diets fed to weanling pigs: dietary tools, Part 1. Anim Biotechnol 2006;17:207e15.
Piva A, Morlacchini M, Casadei G, Gatta PP, Biagi G, Prandini A. Sodium butyrate improves growth performance of weaned piglets during the first period after weaning. Ital J Anim Sci 2002;1:35e41. https://doi.org/10.4081/ijas.2002.35.
Pollmann DS. Probiotics in pig diets. In: Haresign W, Cole DJA, editors. Recent ad- vances in animal nutrition. 1st ed. London, UK: Butterworths; 1986. p. 193e205.
Pollmann DS. Probiotics in swine diets. In: Leger DA, Ho SK, editors. Proc. int. roundtable anim. feed biotechnol. e res. sci. reg. 1st ed. Ottawa, ON, Canada: Agriculture Canada; 1992. p. 65e74.
Poulsen HD. Zinc oxide for weanling piglets. Acta Agric Scand A Anim Sci 1995;45: 159e67.
Poulsen HD. Zinc and copper as feed additives, growth factors or unwanted envi-ronmental factors. J Anim Feed Sci 1998;7:135e42.
Prasad AS, Oberleas D, Miller ER, Luecke RW. Biochemical effects of zinc difficiency: changes in activities of zinc-dependent enzymes and ribonucleic acid and deoxyribonucleic acid content of tissues. J Lab Clin Med 1971;77:144e52.
Prasad AS. Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging. J Trace Elem Med Biol 2014;28:364e71.
Prescott SL, Dunstan JA, Hale J, Breckler L, Lehmann H, Weston S, et al. Clinical effects of probiotics are associated with increased interferon-gamma responses in very young children with atopic dermatitis. Clin Exp Allergy 2005;35:1557e64.
Radcliffe JS, Zhang Z, Kornegay ET. The effects of microbial phytase, citric acid, and their interaction in a corn-soybean meal-based diet for weanling pigs. J Anim Sci 1998;76:1880e6.
Ravindran V, Kornegay ET. Acidification of weaner pig diets: a review. J Sci Food Agr 1993;62:313e22.
Richards JD, Gong J, de Lange CFM. The gastrointestinal microbiota and its role in monogastric nutrition and health with an emphasis on pigs: current under-standing, possible modulations, and new technologies for ecological studies. Can J Anim Sci 2005;85:421e35.
Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, et al. Pre-biotic effects: metabolic and health benefits. Br J Nutr 2010;104(Suppl. 2): S1e63.
Roth FX, Eidelsburger U, Kirchgessner M. Influence of fumaric acid, hydrochloric acid, sodium formate, tylosin and toyocerin on pH, dry matter content, con-centration of carbonic acids and ammonia in different segments of the gastrointestinal tract. 12. Nutritive value of organic acids in piglet rearing. J Anim Physiol Anim Nutr 1992a;68:93e103.
Roth FX, Eckel B, Kirchgessner M, Eidelsburger U. Influence of formic acid on pH, dry matter content, and concentrations of volatile fatty acids and lactic acid in the gastrointestinal tract. 3. Nutritive value of organic acids in piglet rearing. J Anim Physiol Anim Nutr 1992b;67:148e56.
Rudolph FB. The biochemistry and physiology of nucleotides. J Nutr 1994;124(Suppl. 1):124se7s.
Rutkowska-Pejsak B, Mokrzycka A, Szkoda J. Influence of zinc oxide in feed on the health status of weaned pigs. Med Weter 1998;54:194e200.
Saad N, Delattre C, Urdaci M, Schmitter JM, Bressollier P. An overview of the last advances in probiotic and prebiotic field. LWT Food Sci Technol 2013;50:1e16.
Sads OR, Bilkei G. The effect of oregano and vaccination against Glasser's disease and pathogenic Escherichia coli on postweaning performance of pigs. Ir Vet J 2003;56:611e5.
Salobir J, Rezar V, Pajk T, Levart A. Effect of nucleotide supplementation on lymphocyte DNA damage induced by dietary oxidative stress in pigs. Anim Sci 2005;81:135e40.
Sanderson IR, He Y. Nucleotide uptake and metabolism by intestinal epithelial cells. J Nutr 1994;124(Suppl. 1):131se7s.
Sauer N, Eklund M, Bauer E, Ganzle MG, Field CJ, Zijlstra RT, et al. The effects of pure nucleotides on performance, humoral immunity, gut structure and numbers of intestinal bacteria of newly weaned pigs. J Anim Sci 2012a;90:3126e34.
Sauer N, Eklund M, Roth S, Rink F, Jezierny D, Bauer E, et al. Short-term effect of dietary yeast nucleotide supplementation on small intestinal enzyme activities, bacterial populations and metabolites and ileal nutrient digestibilities in newly weaned pigs. J Anim Physiol Anim Nutr (Berl) 2012b;96:700e8.
Sauer N, Mosenthin R, Bauer E. The role of dietary nucleotides in single-stomached animals. Nutr Res Rev 2011;24:46e59.
Sauer W, Cervantes M, Yanez J, Araiza B, Murdoch G, Morales A, et al. Effect of di-etary inclusion of benzoic acid on mineral balance in growing pigs. Livest Sci 2009;122:162e8.
Schlimme E, Martin D, Meisel H. Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. Br J Nutr 2000;84(Suppl. 1):S59e68.
Schreier HJ. Biosynthesis of glutamine and glutamate and the assimilation of ammonia. In: Sonenshein AL, Hoch JA, Losick R, editors. Bacillus subtilis and other gram-positive bacteria. Washington, DC: Am Soc Microbiol; 1993. p. 281e5.
Shen YB, Piao XS, Kim SW, Wang L, Liu P, Yoon I, et al. Effects of yeast culture supplementation on growth performance, intestinal health, and immune response of nursery pigs. J Anim Sci 2009;87:2614e24.
Sherry M, Charcosset C, Fessi H, Greige-Gerges H. Essential oils encapsulated in liposomes: a review. J Liposome Res 2013;23:268e75.
Slade RD, Kyriazakis I, Carroll SM, Reynolds FH, Wellock IJ, Broom LJ, et al. Effect of rearing environment and dietary zinc oxide on the response of group-housed weaned pigs to enterotoxigenic Escherichia coli O149 challenge. Animal 2011;5:1170e8.
Slamenova D, Horvathova E, Marsalkova L, Wsolova L. Carvacrol given to rats in drinking water reduces the level of DNA lesions induced in freshly isolated hepatocytes and testicular cells by H(2)O(2). Neoplasma 2008;55:394e9.
Smiricky-Tjardes MR, Grieshop CM, Flickinger EA, Bauer LL, Fahey Jr GC. Dietary galactooligosaccharides affect ileal and total-tract nutrient digestibility, ileal and fecal bacterial concentrations, and ileal fermentative characteristics of growing pigs. J Anim Sci 2003;81:2535e45.
Smith 2nd JW, Tokach MD, Goodband RD, Nelssen JL, Richert BT. Effects of the interrelationship between zinc oxide and copper sulfate on growth perfor-mance of early-weaned pigs. J Anim Sci 1997;75:1861e6.
Song HZ, Xiao K, Ke YL, Jiao LF, Hu CH. Zinc oxide influences mitogen-activated protein kinase and TGF-b1 signaling pathways, and enhances intestinal bar-rier integrity in weaned pigs. Innate Immun 2015;21:341e8.
Sokmen€ M, Serkedjieva J, Daferera D, Gulluce M, Polissiou M, Tepe B, et al. In vitro antioxidant, antimicrobial, and antiviral activities of the essential oil and various extracts from herbal parts and callus cultures of Origanum acutidens. J Agr Food Chem 2004;52:3309e12.
Speranda M, Ðidara M, Speranda T, Domacinovic M, Valpotic H, Kovacevic J, et al. Hydrolyzed brewery yeast product like immunomodulator in weaned piglets. Arch Zootech 2008;11:52e60.
Stahly TS, Cromwell GL, Monegue HJ. Effects of the dietary inclusion of copper and (or) antibiotics on the performance of weanling pigs. J Anim Sci 1980;51: 1347e51.
Stavric S, Kornegay ET. Microbial probiotics for pigs and poultry. In: Wallace RJ, Chesson A, editors. Biotechnology in animal feeds and feeding. 1st ed. Wein-heim, Germany: VCH Verlagsgesellscharft; 1995. p. 205e31.
Stecher B, Hardt WD. Mechanisms controlling pathogen colonization of the gut. Curr Opin Microbiol 2011;14:82e91.
Stein HH, Kil DY. Reduced use of antibiotic growth promoters in diets fed to weanling pigs: dietary tools, part 2. Anim Biotechnol 2006;17:217e31.
Sterritt RM, Lester JN. Interactions of heavy metals with bacteria. Sci Total Environ 1980;14:5e17.
Suiryanrayna MV, Ramana JV. A review of the effects of dietary organic acids fed to swine. J Anim Sci Biotechnol 2015;6:45e55.
Surburg H, Panten J. Common fragrance and flavor materials: preparation, properties and uses. Weinheim: Wiley-VCH; 2006. p. 289e303.
Suryanarayana MVAN, Suresh J, Rajasekhar MV. Organic acids in swine feeding: a review. Agric Sci Res J 2012;2:523e33.
Suttle NF, Angus KW. Effects of experimental copper deficiency on the skeleton of the calf. J Comp Pathol 1978;88(1):137e48.
Suttle NF. Mineral nutrition of livestock. 4th ed. Oxon, U.K: CABI Publishing; 2010. Tanaka R, Mutai M. Improved medium for selective isolation and enumeration of Bifidobacterium. Appl Environ Microbiol 1980;40:866e9.
Teissedre PL, Waterhouse AL. Inhibition of oxidation of human low-density lipo-proteins by phenolic substances in different essential oils varieties. J Agr Food Chem 2000;48:3801e5.
Tran THT, Everaert N, Bindelle K. Review on the effects of potential prebiotics on controlling intestinal enteropathogens Salmonella and Escherichia coli in pig production. J Anim Physiol Anim Nutr 2016. https://doi.org/10.1111/jpn.12666.
Trckova M, Faldyna M, Alexa P, Sramkova Zajacova Z, Gopfert E, Kumprechtova D, et al. The effects of live yeast Saccharomyces cerevisiae on postweaning diar-rhea, immune response, and growth performance in weaned piglets. J Anim Sci 2014;92:767e74.
Tsujinaka T, Kishibuchi M, Iijima S, Yano M, Monden M. Nucleotides and intestine. JPEN J Parenter Enter Nutr 1999;23(Suppl. 5):S74e7.
Tung YT, Chua MT, Wang SY, Chang ST. Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresour Technol 2008;99:3908e13.
Uauy R, Stringel G, Thomas R, Quan R. Effect of dietary nucleosides on growth and maturation of the developing gut in the rat. J Pediatr Gastroenterol Nutr 1990;10:497e503.
Uauy R. Nonimmune system responses to dietary nucleotides. J Nutr 1994;124(Suppl. 1):157se9s.
Underwood EJ. Trace elements in human and animal nutrition. 4th ed. New York, US: Academic Press; 1977.
Upadhaya SD, Lee KY, Kim IH. Protected organic Acid blends as an alternative to antibiotics in finishing pigs. Asian Australas J Anim Sci 2014;27:1600e7.
van der Aar PJ, Molist F, van der Klis JD. The central role of intestinal health on the effect of feed additives on feed intake in swine and poultry. Anim Feed Sci Technol 2017;233:64e75.
van der Peet-Schwering CM, Jansman AJ, Smidt H, Yoon I. Effects of yeast culture on performance, gut integrity, and blood cell composition of weanling pigs. J Anim Sci 2007;85:3099e109.
van Heugten E, Spears JW, Kegley EB, Ward JD, Qureshi MA. Effects of organic forms of zinc on growth performance, tissue zinc distribution, and immune response of weanling pigs. J Anim Sci 2003;81:2063e71.
Vandenbergh PA. Lactic acid bacteria, their metabolic products and interference with microbial growth. FEMS Microbiol Rev 1993;12:221e37.
Waititu SM, Heo JM, Patterson R, Nyachoti CM. Dietary yeast-based nucleotides as an alternative to in-feed antibiotics in promoting growth performance and nutrient utilization in weaned pigs. Can J Anim Sci 2016;96:289e93.
Waititu SM. The role of nucleotides in the nutrition of newly weaned pigs. PhD Diss., Doctoral dissertation. Canada: University of Manitoba; 2016.
Walk CL, Srinongkote S, Wilcock P. Influence of a microbial phytase and zinc oxide on young pig growth performance and serum minerals. J Anim Sci 2013;91: 286e91.
Walk CL, Wilcock P, Magowan E. Evaluation of the effects of pharmacological zinc oxide and phosphorus source on weaned piglet growth performance, plasma minerals and mineral digestibility. Animal 2015;9:1145e52.
Walsh MC, Sholly DM, Hinson RB, Saddoris KL, Sutton AL, Radcliffe JS, et al. Effects of water and diet acidification with and without antibiotics on weanling pig growth and microbial shedding. J Anim Sci 2007;85:1799e808.
Wang XX, Song PX, Wu H, Xue JX, Zhong X, Zhang LY. Effects of graded levels of isomalto-oligosaccharides on the performance, immune function and intestinal status of waned pigs. Asian Australas J Anim Sci 2016a;29(2):250e6. https:// doi.org/10.5713/ajas.15.0194.
Wang Y, Kuang Y, Zhang Y, Song Y, Zhang X, Lin Y, et al. Rearing conditions affected responses of weaned pigs to organic acids showing a positive effect on di-gestibility, microflora and immunity. Anim Sci J 2016b;87:1267e80.
Ward TL, Asche GA, Louis GF, Pollman DS. Zinc-methionine improves growth per-formance of starter pigs. J Anim Sci 1996;74(Suppl. 1):182 [Abstract].
Weaver AC, Kim SW. Supplemental nucleotides high in inosine 5'-monophosphate to improve the growth and health of nursery pigs. J Anim Sci 2014;92:645e51.
Weedman SM, Rostagno MH, Patterson JA, Yoon I, Fitzner G, Eicher SD. Yeast culture supplement during nursing and transport affects immunity and intestinal mi-crobial ecology of weanling pigs. J Anim Sci 2011;89:1908e21.
Wierup M. The Swedish experience of the 1986 year ban of antimicrobial growth promoters, with special reference to animal health, disease prevention, pro-ductivity, and usage of antimicrobials. Microb Drug Resist 2001;7:183e90.
Windisch W, Schedle K, Plitzner C, Kroismayr A. Use of phytogenic products as feed additives for swine and poultry. J Anim Sci 2008;86(Suppl. 14):E140e8.
Wong SY, Grant IR, Friedman M, Elliott CT, Situ C. Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis. Appl Environ Microbiol 2008;74:5986e90.
Wu Y, Pan L, Shang QH, Ma XK, Long SF, Xu YT, et al. Effects of isomalto-oligosaccharides as potential prebiotics on performance, immune function and gut microbiota in weaned pigs. Anim Feed Sci Technol 2017;230:126e35. https://doi.org/10.1016/j.anifeedsci.2017.05.013.
Xia S, Yao W, Zou B, Lu Y, Lu N, Lei H, et al. Effects of potassium diformate on the gastric function of weaning piglets. Anim Prod Sci 2016;56:1161e6.
Xia T, Lai W, Han M, Ma X, Zhang L. Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets. Oncotarget 2017;8: 64878e91.
Xu J, Zhou F, Ji BP, Pei RS, Xu N. The antibacterial mechanism of carvacrol and thymol against Escherichia coli. Lett Appl Microbiol 2008;47:174e9.
Xu YT, Liu LI, Long SF, Piao XS. Effects of organic acids and essential oils on per-formance, intestinal health and digestive enzyme activities of weaned pigs. Anim Feed Sci Technol 2018;235:110e9.
Yin YL, Tang ZR, Sun ZH, Liu ZQ, Li TJ, Huang RL, et al. Effect of galacto-mannan-oligosaccharides or chitosan supplementation on cytoimmunity and humoral immunity in early-weaned piglets. Asian Australas J Anim Sci 2008;21:723e31.
Yu VY. The role of dietary nucleotides in neonatal and infant nutrition. Singapore Med J 1998;39:145e50.
Zentek J, Ferrara F, Pieper R, Tedin L, Meyer W, Vahjen W. Effects of dietary com-binations of organic acids and medium chain fatty acids on the gastrointestinal microbial ecology and bacterial metabolites in the digestive tract of weaning piglets. J Anim Sci 2013;91:3200e10.
Zhang B, Guo Y. Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets. Br J Nutr 2009;102:687e93.
Zhao J, Harper AF, Estienne MJ, Webb Jr KE, McElroy AP, Denbow DM. Growth performance and intestinal morphology responses in early weaned pigs to supplementation of antibiotic-free diets with an organic copper complex and spray-dried plasma protein in sanitary and nonsanitary environments. J Anim Sci 2007;85:1302e10.
Zhao PY, Kim IH. Effect of direct-fed microbial on growth performance, nutrient digestibility, fecal noxious gas emission, fecal microbial flora and diarrhea score in weanling pigs. Anim Feed Sci Technol 2015;200:86e92.
Zhu C, Lv H, Chen Z, Wang K, Wu X, Chen Z, et al. Dietary zinc oxide modulates antioxidant capacity, small intestinal development, and jejunal gene expression in weaned pigs. Biol Trace Elem Res 2017;175:331e8.
Zomborszky-Kovacs M, Bardos L, Biro H, Tuboly S, Wolf-Taskai E, Toth A, et al. Effect of beta-carotene and nucleotide base supplementation on blood composition and immune response in weaned pigs. Acta Vet Hung 2000;48:301e11.