Beneficial Yeast: New weapon to combat Aspergillus Flavus

S. Nada, H. Amra, M. Y. Deabes & E. Omara (2010) Saccharomyces Cerevisiae And Probiotic Bacteria Potentially Inhibit Aflatoxins Production In Vitro And In Vivo Studies. The Internet Journal of Toxicology. 2010 Volume 8 No.1 http://www.ispub.com/journal/the_internet_journal_of_toxicology/volume_8_number_1_32/article/saccharomyces-cerevisiae-and-probiotic-bacteria-potentially-inhibit-aflatoxins-production-in-vitro-and-in-vivo-studies.htm Abstract Saccharomyces cerevisiae and Lactic acid bacteria (Lactobacillus rhamnosus GG and Lactobacillus rhamnosus LC705) potentially inhibited Aspegillus flavus growth and aflatoxins production in YES liquid media. Six groups of rats orally administrated SC (1011 CFU / ml) and LGG & LC705 (109 CFU/ ml) daily for 15 days alone or with 2 mg / ml aflatoxin B1 (AFB1) in corn oil, significantly reduced serum ALT, AST, GGT, creatinine, and BUN compared with AFB1-tereated group. No deaths occurred in any combined treatment with AFB1, while a 30% mortality rate was recorded in the AFB1-treated group. Blood glutathione (GSH) levels significantly increased in groups treated with single-treatment of S. cerevisiae, LGG & LC705 or concomitant with AFB1; however, AFB1-treatment alone severely depleted GSH level more than other treatments. Histopathological examination of liver and kidney in rats treated with AFB1 showed necrosis, vacuolar degeneration and fatty changes in hepatocytes; cellular swelling and pyknotic nuclei of proximal convoluted tubules in renal tissue. DNA content decreased significantly in liver and kidney tissues with AFB1-administration, these findings were ameliorated by probiotec bacteria and S.cervisiae treatment. Conclusion: These probiotics may have good medical benefits to diminish the aflatoxins production in vitro and in vivo studies. --------------------------------------------------------------------------------