Clinical Micotoxicosis

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VARIOUS MYCOTOXINS BIOCHEMICAL EFFECTS
(BORRELL 1989)
Aflatoxin* Hepatic size enlargement
Increase in proto-combining time
Pro-ventricle size enlargement
Laying reduction
Embryo development delay
Sericeous protein reduction
Increase in coagulation time
Corporal size reduction
Gizzard size enlargement
Testicle atrophia
Embryo malformations
Antibody absorption reduction
     
Ochratoxin A* Kidney weight increase
Increased Urate deposits
biliary conducts multiplication
Immunization defenses reduction
Corporal Weight loss
Sexual maturity delay
Laying reduction
     
Rubratoxin B* Hepatic hypertrophy
Embryo malformation
Fabricius bag Atrophia
     
Diacetoxycirpernol* Lymphatic tissue necropsy
Biliary vesicle necropsy
Spinal cord necropsy
     
T-2* Mouth necropsy
VII factor and proto-combining reduction
Hepatic hypertrophy
Subcutaneous edema
     
Zearalenone* Liver weight increase
Kidney weight increase
Testicle intestinal fibrosis
Testicle weight reduction

Heart weight increase
Estrogenic effect
Crest size reduction
     
Citrinin* Renal size enlargement
Urine production increase
Increase in water Consumption
     
Penicilloic* Acid Sterigmata-cystine Heart muscle alteration
Hepatic necropsy
Renal necropsy
     
Penitrem A and B* Neurotoxic  
     
Patulin Hepatic alteration  
     
Note: The combination of two or more mycotoxins, even at LOW levels can be more toxic than one toxin at a high level and might NOT show the same symptoms as one mycotoxin.

     
     
SWINE CLINICAL MYCOTOXICOSIS
(OSWEILER, 1992)
Toxin
Category
Clinical Effect
Aflatoxin
Development / grow-out
* Growth and feed conversion reduction.
* Liver microscopic lesions, colangio-hepatitis, hepatic serological enzymes enlargement
* Feed consumption reduction, hardened hair, hypertony.
* Coagulation apathy, depression, anorexia.
* Acute hepatitis, and mortality in 3 to 10 days.
     
  Sow / Reproductive Stage
* No conception effect, normal slow growing suckling pigs because of aflatoxin in the milk.
     
Ochratoxin and Citrinin
Grow-out
* Moderate renal lesions. reduction in weight gain.
* Polydypsia, reduced growth, glycosuria and polyuria
     
  Sows / Reproductive Stage
* Normal when they eat on the first month
     
Tricotecen T-2 and DAS
Development /Grow-out
* Reduced feed consumption, oral and dermal irritation.
* Full rejection and vomiting.
     
Deoxynivalenol
  * Reduced feed consumption.
* Full rejection
     
Zearalenone F-2
Reproductive Sows
* vulvovaginitis, Prolapse
     
  Cycling sows
* Persistency of anestra lutea body.
* Pseudopregnancy
     
  Pregnant sows
* Early embryo mortality when feeding
* 1-3 weeks post-service.
     
Fumonisin
Swine
* Acute lung edema, hepatitis, lymphoblasts genesis paralysis, reduced feed consumption
     
     
VARIOUS MYCOTOXINS BIOCHEMICAL EFFECTS
(SHULLY CHEEKE, 1983)
SYSTEM
MYCOTOXINS
* Metabolic System:
 
- Carbohydrates metabolism
Aflatoxin, Ochratoxin A, Phomopsin A
- Lipids metabolism
Aflatoxin, Ochratoxin A, T-2, Citrinin, Rubratoxin B
- Vitamin assimilation
Aflatoxin, dicumarol
- Protein synthesis
Aflatoxin, Trichothecenes
- Mitochondrial respiration
Aflatoxin, Ochratoxin A, Rubratoxin B, Patulin
* Endocrine system
Aflatoxin, Zearalenone, Ergot, Alkaloids
* Skeletal system
Aflatoxin, Ochratoxin A
   
Note: The combination of two or more mycotoxins, even at LOW levels can be more toxic than one toxin at a high level and might NOT show the same symptoms as one mycotoxin.

   

 

 
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