C-13 internal standards for mycotoxins analysis: trend or necessity?

Date of publication : 10/29/2021
Source : https://www.newfoodmagazine.com/

Chiara Dall’Asta, food chemistry professor at the University of Parma, debates the use of C-13 internal standards in mycotoxins analysis.


Mycotoxins are fungal secondary metabolites, occurring in a wide spectrum of food and feed commodities worldwide. They may exert acute and chronic adverse effects on humans and animals.

In consideration of the typical mycotoxin co-occurrence in crops and their extensive combination in food, co-exposure to multiple mycotoxins through one’s diet should be considered for a proper risk assessment. A regulatory framework is currently enforced in many parts of the world, although still not harmonised at a global level. In the European Union, according to the farm-to-fork precautionary approach, the maximum permitted levels are particularly low, reaching sub-part per billion in the case of the most dangerous aflatoxins (eg, 0.05 μg/kg for aflatoxin M1).

Owing to the efforts of the agro-food system to meet regulatory compliance, the accuracy and reliability of analytical methods used in the industry and in official labs must be the highest possible, to avoid both false positive and false negative results.

Over the last 20 years, mass spectrometry has become the benchmark in food analysis for a large range of contaminants and, more recently, multi-analyte methods have been established as the golden standard for many classes of chemicals. However, analysts working with mass spectrometry are well aware of the possible matrix effect, due to ion suppression or ion enhancement, that may influence accurate quantification.

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