EFSA promotes a public consultation on Ochratoxin A

Date of publication : 4/2/2020
Source : https://www.efsa.europa.eu/

The European Food Safety Authority (EFSA) is seeking feedback from interested parties on its scientific opinion about public health risks related to the presence of Ochratoxin A (OTA) in food – a mycotoxin naturally produced by fungi such as the Penicillium and Aspergillus species.

OTA is found in a variety of foods including grains and grain products, preserved meats, fresh and dried fruits. It is also found in breast milk.

EFSA previously assessed public health risks related to OTA in food in 2006. Experts concluded that OTA accumulates in the kidney and is particularly toxic to this organ. At high doses OTA also causes kidney tumours in rats. EFSA set a tolerable weekly intake (TWI) of 120 nanograms per kilogram of body weight.

More information has since become available suggesting that OTA may be genotoxic and carcinogenic. In such cases, EFSA experts calculate a margin of exposure (MOE) for consumers.

In general, the higher the MOE, the lower the level of concern for consumers. The estimated MOE for OTA is below 10,000 across most consumer groups, suggesting a possible health concern.

What is the MOE?

The MOE is a tool used by risk assessors to characterise the risk from exposure to genotoxic and carcinogenic substances, which may be found in food or feed. It provides an indication of the level of safety concern about a substance’s presence in food but does not quantify the risk.

The MOE is a ratio of two factors: the dose at which a small but measurable adverse effect is observed and the level of exposure to the substance.

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