Impact of Deoxynivalenol in the large intestine of pre-pubertal gilts
The Effect of 42-Day Exposure to a Low Deoxynivalenol Dose on the Immunohistochemical Expression of Intestinal ERs and the Activation of CYP1A1 and GSTP1 Genes in the Large Intestine of Pre-pubertal Gilts
Published: March 20, 2024
Summary
INTRODUCTION Mycotoxins are substances that occur naturally in the environment (1, 2). In addition to mycoestrogens such as zearalenone (3, 4), selected trichothecenes, including DON and/or its metabolites (but in vitro), can affect steroidogenesis (2) and changes in gene expression, which suggests that these compounds could disrupt hormonal homeostasis (1). Deoxynivalenol (DON), a polar orga...
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16 de diciembre de 2024
Wonderful job done on this challenge. More should be done on other spp- to make the farm save from this 'silent terrorist'. Bravo.
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2 de julio de 2026
Very valuable study. It highlights that even low-dose DON exposure should not be underestimated, as mycotoxin risks may affect intestinal health and overall animal performance beyond visible symptoms.
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Francis Simard
Trouw Nutrition
Agr., M. Sc. / Nutrition and Development Director at Trouw Nutrition Canada
United States
United States
