Continued performance without AGPs
In 1988 Norel opened their Biotechnology plant in Leon (Spain) to start research
and production of probiotics for animal nutrition and their effect on the intestinal
health and performance parameters. This Biotechnology plant is the only one
in Spain specialised in the production of probiotics for animal nutrition.
Norel’s Biotechnology development been carried out with the important
collaboration of national and international Universities and Research Centres.
The position of Norel as manufacturer of probiotics allows them to offer an
impressive range of products and blends based on sporulated and lyophilised
Norel & Nature considers that the efficiency of their products is obtained
due to the strict quality control of the productive process and of the end product.
Controlling intestinal microflora
FECINOR is a biological additive isolated
from the ileum of healthy piglets. This origin ensures natural adaptation to
the environmental conditions in the intestines. FECINOR has a high capacity for
rapid colonization of the intestine in post-weaned piglets.
The intestinal microbial flora of the animal host is a complex ecologic system
that produces a significant impact on the host. Aerobic and anaerobic bacteria
of the intestinal flora influence numerous anatomic, physiologic, and immunologic
parameters of the host.
Healthy intestinal flora represents an important defence mechanism, which
suppresses the establishment of enteric pathogenic bacteria, induces immunologic
responses, and competes for attachment sites thereby creating a restrictive
Normal microflora of the intestinal tract consists of a diverse population
of bacteria. All of these bacteria are in competition for survival. The biological
activity of probiotic bacteria is due in part to their ability to compete for
the enterocytes. They compete for attachment sites and nutrients from the ingested
feed passing through the intestine. Each species has specific requirements
for growth and is affected by relative acidity or alkalinity (pH) of their
environment and by products produced by other bacteria. One of the advantages
of the early gut colonization is that, by occupying all the available receptor
sites in the gut, there is inhibition of the binding of enteric pathogens and
this is due to the by a process of competitive exclusion.
Probiotic bacteria also exert an influence on commensal micro-organisms by
the production of lactic acid and bacteriocins. These substances inhibit growth
of pathogens and also alter the ecological balance of enteric commensals. A
probiotic is a viable microbial dietary supplement that beneficially affects
the host through its effects in the intestinal tract. Several health-related
effects associated with the intake of probiotics, including alleviation of
lactose intolerance and immune enhancement, have been reported.
The fact that E. Faecium
is protected in FECINOR by means of polysaccharide
layers allows it to pass through the stomach without affecting the acid pH. On
reaching the intestine, it multiplies at a rapid rate (doubling in CFU every
19 minutes), and adheres to the intestine lining by means of a membrane which
makes it possible for it to form the “biological barrier”
protects the body against disease-causing germs.
Fecinor’s fast rate of colonization and affinity for the environment,
allow it to compete with the enterobacteria for both the lining “loci” and
for the nutrients in the intestinal environment. This two-fold competition,
by rapidly forming the aforementioned protective coating, contributes to
the flora that is beneficial for the animal by preventing unwanted bacteria
FECINOR produces different enzymes (proteases, amylases etc…) in sufficient
amounts to make the feed more digestible. Protease activity in culture broth
with soya peptone was measured by colorimetric method. The change to red colour
in tube containing Fecinor is produced by the protein degradation in amine
groups, compared with the control group.
FECINOR inhibits the proliferation of undesirable pathogens not only by the
quantity of LA produced - Fecinor has a sugar yield of 50% in L-lactic acid – but
also because of the production of factors that are detrimental to the growth
of pathogenic bacteria.
Effect of E. faecium over S. choleraesuis: the pathogen S. choleraesuis were
controlled by cell free extracts of E. faecium even at relatively high pH values.
also helps to restore the intestinal flora: the balance of intestinal flora
changes following treatments with antibiotics and also in situations of stress.
Some bacteria are sensitive to antibiotics and with their application the microflora
profile is modified and certain microorganisms grow more than others depending
on the antibiotic used; usually the endogenous lactobacillus and bifidobacteria
are more sensitive to antibiotic and their recuperation time is slower than
E. coli strains. So in this case - and stress situations - is very important
to help the intestinal lactic acid bacteria with the inclusion of probiotics
with fast growing capacity to make the environment comfortable for their development.
Duplication Capacity (*) of different bacteria strains (minutes):
Escherichia coli 18-20
Saccharomyces cerevisiae 200
Bacillus subtilis 60
(*) Duplication capacity: time needed to doubling the number of bacteria.
Optimal results in post weaning piglets
FECINOR (E. faecium CECT 4515), is now registered
for use in piglets feed under the number E 1713. This consolidates Norel & Nature’s
position in the production of zoo-technical products that improve intestinal
flora and animal health in piglets. To gain this registration all necessary
criteria of quality, feed efficiency and safety were surpassed.
It is well known and researched that during weaning and in the immediate post-weaning
period, the piglets suffer an important alteration on the intestinal wall.
Stress, withdrawal from the mother and the new diet, destroy the enterocites
involved in nutrient absorption. During the first days after weaning the animals
lose weight and only afterwards increase feed intake; the effect of this high
intake on the damaged intestinal wall produces an increase of not digested
feed that is used by the pathogens to grow in the distal part of the intestine.
The final result is an increase in the incidence of diarrhoea. This affects
smaller animals more than the larger, heavier ones so the difference between
animals increases and uniformity decreases.
Including Fecinor in the prestarter feed (even before weaning) protects the
enterocites and stimulates feed intake the day after weaning, avoiding enteric
diseases, helping the regeneration of enterocites and improving enzyme production
and nutrient absorption. So, it can reduce the losses in weight and facilitate
adaptation to the diet.
It has been proven that Fecinor promotes the development of lactic acid bacteria
in piglets: the results using Fecinor improved the performance and group uniformity
and decreased diarrhoeas.
The analysed data obtained from six experiments on the inclusion of Fecinor,
carried out in international research centres, showed significant improvements
on daily weight gain and feed conversion.
Fecinor showed a good response against pathogens like hemolitical coli, several
trials (using an intestinal simulator) resulted in a reduction of the pathogen
when Fecinor was included (measured after 3 hours).
Diarrhoea prevention: Fecinor contributes to improve the intestinal wall protection;
the damage to enterocites is lower when they are protected by lactic bacteria.
Diarrhoea incidence is the result of bad nutrient digestibility and absorption
and it is accentuated by the increasing permeability of the intestinal wall that
produces water and electrolyte losses.
There are different products, such as pectins, to prevent these symptoms, but
they improve neither the feed efficiency nor the microflora. The inclusion of
Fecinor with or without these products contributes to reduce the effects of diarrhoea
improving the feed efficiency and reducing the pathogenic bacteria.
The inclusion of Fecinor in piglet diets improves the performance.
The inclusion of Fecinor was not affected by the inclusion of Zinc oxide and
reduces the E. coli incidence.