Mycotoxins control in pigs
Calibrin®-Z Adsorbs Fumonisin
Therefore, this study was conducted to evaluate the Fumonisin-binding performance of Calibrin®-Z in pigs. Results demonstrate significant protective action against the rious biological effect of Fumonisin exposure.
Procedure
Eighteen healthy piglets with an average initial weight of 11.8 kg were evaluated over a period of 42 days. The piglets were randomly assigned to three treatment groups, equating to six replicates per group.
Animals were housed in 18 pens equipped with semi-automatic feeders and automatic drip feeders. Temperature control and adequate ventilation was maintained throughout the study period.
Diets were iso-nutritional and formulated in accordance with the nutritional requirements of the National Research Council (NRC 1998). No mycotoxin was detected in the feed used.
Control
(No Fumonisin and no Calibrin-Z)
Fumonisin
(Control + 50 ppm Fumonisin)
Fumonisin + Calibrin-Z
(50 ppm Fumonisin + 0 .5% Calibrin-Z)
STUDY PROTOCOL
The Brazilian institution where this study was conducted uses a high mycotoxin inclusion rate model to realistically assess anti-mycotoxin efficacy. The high challenge inclusion is deemed a necessary counter-measure to the tightly controlled testing environment and general good health of study animals.
In this evaluation, a binder:toxin ratio of 100:1 was evaluated to determine baseline efficacy. In practice, Amlan International recommends using 1 kg Calibrin-Z per metric ton of feed to provide the most comprehensive protection in a real world environment.
CALIBRIN-Z COMPONENTS
Activated montmorillonite Amlan montmorillonite processed under optimized time, temperature and pressure conditions to maximize adsorptive detoxification properties.
Animal Performance Data
Adding Calibrin-Z to a fumonisin contaminated diet improved average daily feed intake by 21.2%, weight gain by 21.4%, and end weight by 15.4% compared to pigs fed Fumonisin with no Calibrin-Z.
The pigs fed Calibrin-Z weighed 5.31 kg more than the pigs fed 50 ppm Fumonisin alone at the end of the 42-day study.
Looking at Biological Protection as determined by the equation below:
Calibrin-Z provided Biological Protection of 98.6% and 80% for Average Daily Feed Intake and Final Weight, respectively.
Study Findings
Calibrin-Z demonstrated significant in vivo protection based on animal performance compared with Fumonisin treated pigs receiving no antimycotoxin binder.
Under control led conditions, with a high Fumonisin challenge level, the Calibrin-Z treated pigs performed equivalent to the control group. This group also demonstrated 15.4% greater average weight compared to the Fumonisin challenge only study group. These results indicate the routine use of Calibrin-Z will reduce the costly negative effects of Fumonisin on the health and productivity of pigs.
I am a consultant for several swine farmers and I find very interesting your study on fumonisin in pigs.
This trial was conducted by SAMITEC in Brazil which are the facilities where LAMIC conducts the In Vivo research studies for mycotoxin binders to obtain approval in Brazil based on the new government regulations.
A key requirement to obtain LAMIC approval is that the product been tested has to have statistical improvement on the organ(s) that the mycotoxin been tested affects and /or statistical improvement on biomarker of that mycotoxin.
If the product obtains improvement on the organ(s) then LAMIC is the one that issues the repot of the study done by SAMITEC indicating product is approved for the control of that specific mycotoxin.
LAMIC posts this approval in their web site and gives to each manufacturer of mycotoxin binder a password and a login so that users of mycotoxin binders can verified for which mycotoxin(s) the product has been approved for.
In the case of fumonisin the organs been affected are heart, lung, liver and the biomarker is sphingolipids in blood.
In this report issued by SAMITEC clearly shows that Calibrin Z was not able to protect the heart, lung and liver and there is no mention of improvement on the sphingolipids in blood.
Calibrin Z in its literature indicates that it has been approved in by LAMIC for the control of Zearalenone by protecting the reproductive organs.
Me and my costumers would like to verify that Calibrin Z has been approved by LAMIC for the control of Zearalenone and Fumonisin. Which is the password and log in for Amlan?
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