Assessing the Risks of HoBi-Like Viruses in Cattle

Scientists are tracking a new species of pestivirus that could pose a threat to U.S. cattle. Tentatively called “HoBi-like viruses,” they are related to bovine viral diarrhea viruses (BVDV), which cause significant economic losses to cattle producers worldwide. Originally found in South America, HoBi-like viruses have since been associScientists are tracking a new species of pestivirus that could pose a threat to U.S. cattle. Tentatively called “HoBi-like viruses,” they are related to bovine viral diarrhea viruses (BVDV), which cause significant economic losses to cattle producers worldwide.

Originally found in South America, HoBi-like viruses have since been associated with disease outbreaks in Southeast Asia and more recently in Europe. Signs of infection include slowed growth, reduced milk production, higher rates of reproductive and respiratory diseases, and a higher incidence of death among young animals. No vaccines are available to specifically prevent HoBi infection in cattle. 

These findings, published in Veterinary Microbiology and the Journal of Veterinary Diagnostic Investigation, indicate a need for new diagnostics and vaccines specific to these viruses. Ridpath, who is in NADC’s Ruminant Diseases and Immunology Unit, also demonstrated that acute HoBi infections in cattle result in immunosuppression. Like BVDV, HoBi has the ability to cross the placenta, infecting the fetus and establishing a lifelong infection in an animal. Such animals are referred to as “persistently infected.”

“A calf born persistently infected with BVDV is like a ‘Typhoid Mary,’ shedding virus into the environment through its tears, blood, urine, feces, and skin,” Ridpath says. “All of its tissues carry the virus. We have found that the same is true of calves persistently infected with HoBi-like viruses, and they can transmit the virus to other calves, sheep, goats, and pigs.”

Ridpath and her colleagues at NADC are collaborating with researchers in Brazil and Italy to investigate the prevalence of HoBi. In a study published in the Journal of Veterinary Diagnostic Investigation in 2014, the team conducted a survey of fetal bovine serum collected from animals in the United States. No HoBi-like viruses were detected. This suggests that the viruses have not invaded the country.